Article
Endocrinology & Metabolism
Natalya Sergeevna Glebezdina, Irina Valerievna Nekrasova, Anna Alexandrovna Olina, Gulnara Kamilyevna Sadykova, Elena Michajlovna Kuklina
Summary: The population of Th17 cells in pregnant women, which produce IL-17, has a dual role and is tightly controlled during pregnancy. The pineal hormone melatonin may play a role in this regulation and can enhance the differentiation of Th17 cells in vitro. The effects of melatonin are limited to the first trimester of pregnancy and are mediated by both membrane and nuclear melatonin receptors. Considering the promising use of exogenous melatonin in reproductive-related issues, its immunoregulatory effects need to be taken into account.
JOURNAL OF PINEAL RESEARCH
(2023)
Article
Oncology
Khalid W. Kalim, Jun-Qi Yang, Mark Wunderlich, Vishnu Modur, Phuong Nguyen, Yuan Li, Ting Wen, Ashley Kuenzi Davis, Ravinder Verma, Qing Richard Lu, Anil G. Jegga, Yi Zheng, Fukun Guo
Summary: Targeting Cdc42 in Treg cells has shown promising therapeutic potential in cancer immunotherapy, by enhancing antitumor T-cell immunity without triggering autoimmune reactions. This approach involves inducing Treg cell instability through Cdc42 targeting, leading to improved immune responses against tumors.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Review
Oncology
Hiroyoshi Nishikawa, Shohei Koyama
Summary: With the widespread use of immunotherapies in cancer treatment, understanding the immune landscape in the tumor microenvironment has become crucial. Regulatory T cells (Tregs) play a key role in cancer immunity but also contribute to immune evasion by tumor cells. Targeting Tregs is considered a crucial aspect of cancer immunotherapy, especially in tumors with abundant Treg presence.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2021)
Article
Hematology
Julian Swatler, Laura Turos-Korgul, Marta Brewinska-Olchowik, Sara De Biasi, Wioleta Dudka, Bac Viet Le, Agata Kominek, Salwador Cyranowski, Paulina Pilanc, Elyas Mohammadi, Dominik Cysewski, Ewa Kozlowska, Wioleta Grabowska-Pyrzewicz, Urszula Wojda, Grzegorz Basak, Jakub Mieczkowski, Tomasz Skorski, Andrea Cossarizza, Katarzyna Piwocka
Summary: Leukemic extracellular vesicles play a role in stimulating immunosuppressive Tregs and promoting leukemia growth. The study identifies Rab27a-dependent secretion of leukemic EVs as a potential therapeutic target in myeloid neoplasms.
Review
Pharmacology & Pharmacy
Xiaoya Li, Huihui Xu, Jing Huang, Dan Luo, Shuang Lv, Xiangchen Lu, Cheng Xiao
Summary: Regulatory T cells (Tregs) play a crucial role in promoting immune tolerance and maintaining immune system homeostasis. Dysfunction of Tregs is closely linked to rheumatoid arthritis (RA), and research on Tregs in RA has made significant progress in both basic and clinical aspects.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Oncology
Huanhe Ni, Huanling Zhang, Lin Li, He Huang, Hui Guo, Lin Zhang, Chunwei Li, Jing-Xiao Xu, Cai-Ping Nie, Kui Li, Xiaoshi Zhang, Xiaojun Xia, Jiang Li
Summary: In this study, it was found that increased STING and CCL22 levels, as well as higher levels of FOXP3(+) cells and lower levels of CD8(+) cells in tumor tissues of cervical cancer, predicted poor survival. Activation of STING signaling in cooperation with T cell receptor and other signals promoted iTreg differentiation in both human and murine CD4(+) naive T cells. Additionally, tumor-derived exosomes were found to activate STING signaling in tumor-infiltrated T cells, leading to iTreg expansion.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Article
Agronomy
Qiang Wang, Weiwei Xu, Changzhong Ren, Chao Zhan, Chunlong Wang, Junwei Li, Qinyong Ren, Xiaotian Liang, Liming Wei, Dabing Xiang, Junying Wang, Laichun Guo
Summary: Saline-alkali stress is a major constraint on oat seed germination. The study investigated the effects of different concentrations and soaking times of melatonin (MT) on oat seed germination under saline-alkali stress. The results showed that MT treatment improved seed germination by enhancing antioxidant activity and osmoregulatory substances, thereby increasing oat seed tolerance to saline-alkali stress.
Article
Plant Sciences
Yongqi Yin, Chunping Wang, Chao Cheng, Zhengfei Yang, Weiming Fang
Summary: This study investigated the effects of methyl jasmonate (MeJA) treatment on melatonin (MT) biosynthesis in mustard sprouts. The results showed that MeJA significantly increased MT content in the sprouts but inhibited growth. MeJA induced the expression of genes related to MT synthesis and increased the abundance of tryptophan-related proteins. This study provides insights into the regulation of endogenous MT synthesis in plants.
PLANT PHYSIOLOGY AND BIOCHEMISTRY
(2023)
Article
Multidisciplinary Sciences
Angelika Schmalzl, Tamara Leupold, Lucas Kreiss, Maximilian Waldner, Sebastian Schuermann, Markus F. Neurath, Christoph Becker, Stefan Wirtz
Summary: IRF-1 is a transcription factor that plays a crucial role in regulating the accumulation of intestinal ILC3s and the production of effector cytokines. It is upregulated during infection to prevent pathogen dissemination and promote the release of protective cytokine IL-22. IRF-1 also allows ILC3s to physiologically respond to IL-23 stimulation by controlling their numbers and activation.
NATURE COMMUNICATIONS
(2022)
Review
Immunology
Rui Zhang, Jinlin Miao, Ping Zhu
Summary: Regulatory T (Treg) cells are crucial in maintaining immune homeostasis and are involved in various diseases, particularly autoimmune diseases. Understanding the heterogeneity of Treg cells can provide new insights for selective therapeutic manipulation and treatment of these diseases.
AUTOIMMUNITY REVIEWS
(2021)
Review
Cell Biology
John C. Charpentier, Philip D. King
Summary: Endocytosis, once primarily viewed as a means to neutralize pathogens or facilitate feeding, is now known to regulate a wide range of eukaryotic cell processes, including signal transduction, mitosis, lipid homeostasis, and directed migration. Various forms of endocytosis play important roles in regulating alpha beta and gamma delta T cell functions, such as T cell receptor signaling, antigen discovery by trogocytosis, and activated cell growth. This article examines the contribution of both clathrin-mediated and clathrin-independent mechanisms of endocytosis to T cell biology.
CELL COMMUNICATION AND SIGNALING
(2021)
Article
Medicine, Research & Experimental
Xiaoyuan Hu, Yongkang Ni, Fengying Wang, Zhen Ni, Tao Jin, Yuefei Li, Mingjian Ni
Summary: This study identified key genes in strong responder HICs that help the immune system control HIV-1 infection. The results will be valuable for developing therapeutic targets. DEGs related to general immune responses had the highest correlation with strong responding HICs, while DEGs mainly related to the apoptotic process had the highest correlation with weak responder HICs. Key genes such as CD8A and CCT2, as well as TMEM132C and S100A9, were found to be differentially expressed in HICs and HAART. The immune scores and flow cytometry confirmed lower levels of CD4+ and CD8+ T cells in HICs compared to HAART in whole blood.
Article
Oncology
Mengmeng Jiang, Yang Yang, Liling Niu, Ping Li, Yibo Chen, Ping Liao, Yifei Wang, Jingbin Zheng, Fengyang Chen, Huanhuan He, Hui Li, Xin Chen
Summary: miR-125b-5p regulates Tregs function and TNFR2 expression, enhancing antitumor efficacy.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Article
Horticulture
Qiulan He, Xi Wu, Ying Liu, Wei Zhang, Jing Liu, Shahzad Munir, Meirong Hai
Summary: In the era of climate change, the rise in temperature can adversely impact the potato growth, yield and even threaten food security. This study provides experimental evidence on the heat tolerance mechanisms in potato plants. The hormone melatonin (MT) has been found to improve potato tolerance to high temperatures, and this study investigates the physiological and molecular mechanisms by introducing exogenous MT to potato seedlings under high-temperature stress. The results show that MT enhances photosynthesis and antioxidant capacity, alleviating the damage caused by high temperature.
SCIENTIA HORTICULTURAE
(2023)
Article
Horticulture
Qiulan He, Xi Wu, Ying Liu, Wei Zhang, Jing Liu, Shahzad Munir, Meirong Hai
Summary: The introduction of exogenous melatonin improves heat tolerance in potato seedlings by enhancing photosynthesis and antioxidant capacity, thus mitigating damage caused by high temperature stress.
SCIENTIA HORTICULTURAE
(2023)
Article
Medicine, Research & Experimental
S. V. Shirshev, E. G. Orlova, O. A. Loginova, I. V. Nekrasova, O. L. Gorbunova, I. L. Maslennikova
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE
(2018)
Article
Medicine, Research & Experimental
N. S. Glebezdina, A. A. Olina, I. V. Nekrasova, E. M. Kuklina
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE
(2018)
Article
Biochemistry & Molecular Biology
S. Shirshev, I. Nekrasova, O. L. Gorbunova, E. G. Orlova
DOKLADY BIOCHEMISTRY AND BIOPHYSICS
(2019)
Article
Medicine, Research & Experimental
S. V. Shirshev, I. V. Nekrasova, O. L. Gorbunova, E. G. Orlova
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE
(2019)
Article
Biochemistry & Molecular Biology
Anna Olina, Anton Kuzmenko, Maria Ninova, Alexei A. Aravin, Andrey Kulbachinskiy, Daria Esyunina
Article
Chemistry, Physical
Anna Olina, Miroslav Piska, Martin Petrenec, Charles Hervoches, Premysl Beran, Jiri Pechousek, Petr Kral
Article
Biochemistry & Molecular Biology
Elena Kuklina, Irina Nekrasova, Natalia Glebezdina
Summary: Semaphorin 4D (Sema4D) is widely present in the immune system and plays a crucial role in T lymphocyte activation. The activation of membrane Sema4D leads to phosphorylation of Lck/ZAP-70, suggesting its role as a receptor in immune regulation.
MOLECULAR IMMUNOLOGY
(2021)
Article
Immunology
Irina Nekrasova, Sergei Shirshev
JOURNAL OF NEUROIMMUNOLOGY
(2020)
Article
Endocrinology & Metabolism
Natalya Sergeevna Glebezdina, Irina Valerievna Nekrasova, Anna Alexandrovna Olina, Gulnara Kamilyevna Sadykova, Elena Michajlovna Kuklina
Summary: The population of Th17 cells in pregnant women, which produce IL-17, has a dual role and is tightly controlled during pregnancy. The pineal hormone melatonin may play a role in this regulation and can enhance the differentiation of Th17 cells in vitro. The effects of melatonin are limited to the first trimester of pregnancy and are mediated by both membrane and nuclear melatonin receptors. Considering the promising use of exogenous melatonin in reproductive-related issues, its immunoregulatory effects need to be taken into account.
JOURNAL OF PINEAL RESEARCH
(2023)
Meeting Abstract
Biochemistry & Molecular Biology
A. Olina, A. Agapov, D. Esyunina, A. Kulbachinskiy
Meeting Abstract
Biochemistry & Molecular Biology
A. Olina, A. Kudinova, M. Petrova, A. Aravin, A. Kulbachinskiy, D. Esyunina