Article
Endocrinology & Metabolism
Sonia Sanchez-Bezanilla, Rebecca J. Hood, Lyndsey E. Collins-Praino, Renee J. Turner, Frederick R. Walker, Michael Nilsson, Lin Kooi Ong
Summary: The study found that cognitive function remains impaired post-stroke, while there is modest spontaneous motor recovery over an 84-day period. Reduced neuronal loss and decreased neuroinflammation in the peri-infarct region may explain the spontaneous motor recovery, whereas persistent neuronal loss with increased neuroinflammation and amyloid-beta accumulation in the hippocampus likely contribute to the persistent cognitive dysfunction.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2021)
Article
Immunology
Jing Nie, Yuan Fang, Ying Chen, Aisikeer Aidina, Qi Qiu, Lu Zhao, Xiang Liu, Lin Sun, Yun Li, Chuwen Zhong, Yuan Li, Xia Li
Summary: This study investigated the differences and similarities of peripheral inflammatory parameters in late-life depression (LLD) and amnestic mild cognitive impairment (aMCI). The results showed increased IL-6 levels in the plasma of LLD patients and decreased levels of chemokines (CXCL11 and CCL13), which were associated with abnormal cognitive function and depression scores. A novel model based on proinflammatory cytokines and brief screening tests showed fair accuracy in discriminating between LLD and aMCI.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Neurosciences
Wei Zhou, Mengmeng Hu, Jingrong Hu, Zhiyun Du, Qing Su, Zhangmin Xiang
Summary: The study demonstrates that luteolin can alleviate LPS-induced cognitive impairment by protecting neurons through inhibiting the overproduction of inflammatory cytokines. This finding suggests the potential application of luteolin in therapeutic research of neuroinflammation-related neurodegenerative diseases.
NEUROTOXICITY RESEARCH
(2021)
Article
Medicine, Research & Experimental
Lamis I. Alotayk, Maha A. Aldubayan, Sattam K. Alenezi, Md Jamir Anwar, Ahmad H. Alhowail
Summary: Chemotherapeutic agents commonly used for treating various cancers often lead to chemobrain, which is characterized by difficulties in learning and memory processes that can persist for years. This study used a rat model of neuroinflammation to evaluate cognitive function after treatment with these agents and assess the possible involvement of thyroid toxicity in chemotherapy-induced cognitive dysfunction.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Review
Clinical Neurology
Abir A. Rahman, Narayanappa Amruta, Emmanuel Pinteaux, Gregory J. Bix
Summary: Stroke is a major cause of death and disability globally, but therapeutic options are limited. Neurogenesis induced by stroke injury is of therapeutic interest. Understanding the interplay between neuroinflammation and neurogenesis is crucial for future stroke therapy development.
TRANSLATIONAL STROKE RESEARCH
(2021)
Article
Multidisciplinary Sciences
Arina Ponomarenko, Anna A. Tyrtyshnaia, Evgeny A. Pislyagin, Inessa Dyuizen, Ruslan M. Sultanov, Igor Manzhulo
Summary: The results of this study demonstrate that DHEA has the potential to promote cognitive recovery in rats with mild traumatic brain injury by inhibiting pro-inflammatory microglial cells activity, reducing levels of pro-inflammatory markers, and increasing production of anti-inflammatory cells and antioxidant enzymes. This suggests that DHEA has a complex effect on neuroinflammation processes, highlighting its therapeutic potential.
SCIENTIFIC REPORTS
(2021)
Review
Endocrinology & Metabolism
Mandeep Kaur, Saurabh Sharma
Summary: Stroke is the second leading cause of death in developed countries, and it is also the primary cause of disability and cognitive impairment. Multiple factors, such as age, family history, hypertension, and diabetes, contribute to the risk of cognitive impairment and dementia after stroke. Recent research has revealed complex cellular changes and molecular mechanisms associated with stroke-related cognitive impairment.
METABOLIC BRAIN DISEASE
(2022)
Article
Cell Biology
Shengliang Peng, Yun Yu, Juan Li, Danling Jiang, Guohai Xu, Lidong Wu, Jialing Hu
Summary: Neuroinflammation plays a crucial role in the development of cognitive impairment. In this study, a lentiviral vector Hsp22 was used for intracerebroventricular injection pretreatment, and LPS was used to induce cognitive impairment in mice. The results showed that Hsp22 overexpression attenuated microglial activation, inflammatory responses, and apoptosis, and improved cognitive impairment in mice. These findings suggest that Hsp22 overexpression could be a potential therapeutic approach for treating cognitive impairment.
Article
Biochemistry & Molecular Biology
Giovanni Cirillo, Roberta Pepe, Mattia Siciliano, Domenico Ippolito, Dario Ricciardi, Manuela de Stefano, Daniela Buonanno, Danilo Atripaldi, Salvatore Abbadessa, Brunella Perfetto, Minoo Sharbafshaaer, Giovanna Sepe, Simona Bonavita, Alessandro Iavarone, Vincenzo Todisco, Michele Papa, Gioacchino Tedeschi, Sabrina Esposito, Francesca Trojsi
Summary: This study evaluated the effects of bilateral rTMS on plasmatic levels of MMPs and TIMPs, as well as cognitive performances, in MCI patients. The results showed that rTMS treatment reduced MMP1, -9, and -10 levels, increased TIMP1 and TIMP2 levels, and improved visuospatial performances in MCI patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Immunology
Lingling Xiao, Liang Li, Jingcong Huang, Yuting Luan, Jiaying Pan, Yun Gai, Zhenyu Xu
Summary: Salidroside (SAL) has been shown to have protective effects against neuroinflammation and cognitive impairment in a septic encephalopathy mice model (SEMM) through promoting autophagy.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Sandesh P. Kamdi, Amit Raval, Kartik T. Nakhate
Summary: The study demonstrated that phloridzin can protect mice from LPS-induced memory impairments and neuroinflammation, possibly through mechanisms involving antioxidant, anti-inflammatory, and enhanced cholinergic signaling activity.
Review
Biochemistry & Molecular Biology
Aleksandra Kaliszewska, Joseph Allison, Matteo Martini, Natalia Arias
Summary: Aging is a major contributor to cognitive decline, with mitochondrial dysfunction closely linked to cognitive impairment. Nutrition plays a crucial role in determining mitochondrial functioning, and dietary choices can help counteract cognitive decline in late adulthood.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Virology
Yu Fu, Irene Lorrai, Barry Zorman, Daniele Mercatelli, Chase Shankula, Jorge Marquez Gaytan, Celine Lefebvre, Giordano de Guglielmo, Hyunjae Ryan Kim, Pavel Sumazin, Federico M. Giorgi, Vez Repunte-Canonigo, Pietro Paolo Sanna
Summary: Substance use disorders are common in people with HIV, and excessive opioid intake can lead to neurotoxicity and cognitive impairment.
Article
Pharmacology & Pharmacy
Miao Sun, Yang Li, Min Liu, Qingxiao Li, Likai Shi, Xianghan Ruan, Yuting Huo, Zhikang Zhou, Xiaoying Zhang, Yulong Ma, Weidong Mi
Summary: We found that insulin treatment significantly improved LPS-induced cognitive decline, neuronal injuries, and blood-brain barrier disruption. Insulin treatment inhibited the activation of microglia and astrocytes, and the release of TNF-α and IL-13 in the hippocampus. Furthermore, insulin treatment inhibited LPS-induced ferroptosis in the hippocampus by decreasing iron accumulation levels, regulating ferroptosis-related proteins, and inhibiting oxidative stress injuries and lipid peroxidation.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Article
Neurosciences
Ismaheel Akinwale Adeniyi, Kabirat Temitope Babalola, Victor Adetayo Adekoya, Oyetola Oyebanjo, Abayomi Mayowa Ajayi, Samuel Adetunji Onasanwo
Summary: The study demonstrates that honey has potential in ameliorating lipopolysaccharides-induced neuroinflammation, improving memory impairment, anxiety, and motor coordination, reducing pro-inflammatory cytokine levels and oxidative stress. Additionally, honey restores damaged neuronal structure.
NUTRITIONAL NEUROSCIENCE
(2023)
Article
Immunology
Irina L. Maslennikova, Marina V. Kuznetsova, Irina V. Nekrasova, Sergei V. Shirshev
PATHOGENS AND DISEASE
(2017)
Article
Medicine, Research & Experimental
S. V. Shirshev, E. G. Orlova, O. A. Loginova, I. V. Nekrasova, O. L. Gorbunova, I. L. Maslennikova
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE
(2018)
Article
Medicine, Research & Experimental
N. S. Glebezdina, A. A. Olina, I. V. Nekrasova, E. M. Kuklina
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE
(2018)
Article
Biotechnology & Applied Microbiology
I. L. Maslennikova, M. V. Kuznetsova, N. Toplak, I. V. Nekrasova, D. Zgur Bertok, M. Starcic Erjavec
LETTERS IN APPLIED MICROBIOLOGY
(2018)
Article
Neurosciences
Aleksey Kulesh, Viktor Drobakha, Elena Kuklina, Irina Nekrasova, Vladimir Shestakov
JOURNAL OF STROKE & CEREBROVASCULAR DISEASES
(2018)
Article
Biochemistry & Molecular Biology
S. Shirshev, I. Nekrasova, O. L. Gorbunova, E. G. Orlova
DOKLADY BIOCHEMISTRY AND BIOPHYSICS
(2019)
Article
Biochemistry & Molecular Biology
N. S. Glebezdina, A. A. Olina, I. Nekrasova, E. M. Kuklina
DOKLADY BIOCHEMISTRY AND BIOPHYSICS
(2019)
Article
Medicine, Research & Experimental
S. V. Shirshev, I. V. Nekrasova, O. L. Gorbunova, E. G. Orlova
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE
(2019)
Article
Biochemistry & Molecular Biology
Elena Kuklina, Irina Nekrasova, Natalia Glebezdina
Summary: Semaphorin 4D (Sema4D) is widely present in the immune system and plays a crucial role in T lymphocyte activation. The activation of membrane Sema4D leads to phosphorylation of Lck/ZAP-70, suggesting its role as a receptor in immune regulation.
MOLECULAR IMMUNOLOGY
(2021)
Article
Immunology
Irina Nekrasova, Sergei Shirshev
JOURNAL OF NEUROIMMUNOLOGY
(2020)
Article
Medicine, General & Internal
A. Yu Bykova, A. A. Kulesh, N. A. Kayleva, E. M. Kuklina, V. V. Shestakov
BYULLETEN SIBIRSKOY MEDITSINY
(2019)
Article
Cell Biology
S. V. Shirshev, I. V. Nekrasova, E. G. Orlova, O. L. Gorbunova
BIOCHEMISTRY MOSCOW SUPPLEMENT SERIES A-MEMBRANE AND CELL BIOLOGY
(2017)
Article
Neurosciences
Adam Vacek, Grant Mair, Philip White, Philip M. Bath, Keith W. Muir, Rustam Al-Shahi Salman, Chloe Martin, David Dye, Francesca M. Chappell, Ruediger von Kummer, Malcolm Macleod, Nikola Sprigg, Joanna M. Wardlaw
Summary: This study evaluated the performance of e-ASPECTS software in delineating the extent of intracranial hemorrhage (ICH) on brain CT scans. The results showed that the software achieved excellent or good delineation of ICH extent in 71% of cases. However, it was more likely to over- or under-estimate the extent when ICH was more extensive, intraventricular, or extra-axial.
JOURNAL OF STROKE & CEREBROVASCULAR DISEASES
(2024)
Article
Neurosciences
Mathias Jacobsen Bach, Audrone Jakubauskaite, Ian Law, Otto Molby Henriksen, Inger Havsteen, Alexander Cuculiza Henriksen, Sverre Rosenbaum, Lisbeth Marner
Summary: This study found that the rCBFacz value after ACZ challenge can serve as an important indicator for predicting future cerebrovascular events, with high accuracy and prognostic value.
JOURNAL OF STROKE & CEREBROVASCULAR DISEASES
(2024)
Article
Neurosciences
Tak Kyu Oh, Saeyeon Kim, In-Ae Song
Summary: The study found that many survivors of nontraumatic intracranial hemorrhage in South Korea experience unemployment, decreased household income, and newly acquired disability after intensive care unit admission. However, these changes are not associated with 2-year all-cause mortality.
JOURNAL OF STROKE & CEREBROVASCULAR DISEASES
(2024)
Article
Neurosciences
Eduardo Sousa de Melo, Rodrigo de Paiva Bezerra, Arthur Cesario de Holanda, Maria Junia Lira e Silva, Paloma Peter Travassos, Tayne Fernanda Lemos da Silva, Genova Maria de Azevedo Oliveira, Silvia Marinho Martins Alves, Carolina de Araujo Medeiros, Maria das Neves Dantas da Silveira Barros, Wilson Alves de Oliveira, Gisele Sampaio Silva, Luciana Patrizia Alves de Andrade Valenca
Summary: Cardiac involvement has been found to be the predominant factor correlated with stroke in Chagas disease. While atherosclerosis-related risk factors are prevalent, their influence on ischemic stroke in Chagas disease appears limited.
JOURNAL OF STROKE & CEREBROVASCULAR DISEASES
(2024)
Article
Neurosciences
Pingping Zheng, Ning Zhang, Zixi Chen
Summary: This case presents a rare infectious cause of stroke and air embolism involving a pulmonary abscess and pulmonary vein thrombosis. Early detection, diagnosis, and appropriate treatment of infected systemic embolism in young patients are crucial to prevent serious complications.
JOURNAL OF STROKE & CEREBROVASCULAR DISEASES
(2024)
Article
Neurosciences
Filippo Luca Gurgoglione, Luigi Vignali, Maria Alberta Cattabiani, Emilia Solinas, Giorgio Benatti, Iacopo Tadonio, Federico Barocelli, Chiara Dizdari, Domenico Tuttolomondo, Diego Ardissino, Francesco Nicolini, Giampaolo Niccoli
Summary: The incidence of recurrent ischemic neurological events after transcatheter patent foramen ovale closure is relatively low. Obesity, Risk of Paradoxical Embolism score < 7, and migraine are independent positive predictors of recurrent stroke or transient ischemic attack.
JOURNAL OF STROKE & CEREBROVASCULAR DISEASES
(2024)
Article
Neurosciences
Angelo Cascio Rizzo, Ghil Schwarz, Amedeo Cervo, Giuditta Giussani, Chiara Ceresa, Antonella Gatti, Fausto De Angeli, Cristina Motto, Angelo Guccione, Rachele Tortorella, Giuseppe Granata, Claudia Rollo, Antonio Macera, Mariangela Piano, Guglielmo Pero, Elio Clemente Agostoni
Summary: This study aimed to evaluate the efficacy and safety of endovascular treatment (EVT) in primary and EVT-induced secondary medium-vessel occlusions (MeVO). The results showed that primary MeVO had poorer outcomes in terms of complications, EVT efficacy, and the proportion of patients with a modified Rankin Scale (mRS) of 0-2 at 3 months compared to exclusive large-vessel occlusion (LVO). However, EVT-induced secondary MeVO showed similar safety and efficacy outcomes as exclusive LVO and had better outcomes in terms of mRS 0-2 compared to primary MeVO.
JOURNAL OF STROKE & CEREBROVASCULAR DISEASES
(2024)
Article
Neurosciences
Jing Zhang, Chenming Wei, Jian Wu
Summary: This case report describes a patient with Bloom syndrome who developed acute cerebral infarction along with elevated antiphospholipid antibodies, suggesting a possible association between immune and coagulation abnormalities caused by Bloom syndrome and the development of acute cerebral infarction.
JOURNAL OF STROKE & CEREBROVASCULAR DISEASES
(2024)
Article
Neurosciences
Yunxia Zhou, Shenglan He, Yanhong Hu
Summary: Compared with clopidogrel, DAPT with ticagrelor plus aspirin was associated with significantly lower thromboembolic events without an increase in hemorrhagic events in the treatment of intracranial aneurysms, according to the one-year clinical outcome analysis. However, larger upcoming trials are needed to confirm the effectiveness and safety of ticagrelor-associated DAPT.
JOURNAL OF STROKE & CEREBROVASCULAR DISEASES
(2024)
Article
Neurosciences
Edvania Andrade de Moura Silva, Ludmilla Ribeiro Batista, Marcela Aline Fernandes Braga, Luci Fuscaldi Teixeira-Salmela, Christina Danielli Coelho de Morais Faria, Iza Faria-Fortini
Summary: The study found that stroke severity is the best predictor of self-perceived manual ability at both three and six months after stroke. Age, although significant, contributes little to the prediction of manual ability.
JOURNAL OF STROKE & CEREBROVASCULAR DISEASES
(2024)
Article
Neurosciences
Sidarrth Prasad, Erica M. Jones, Mehari Gebreyohanns, Veronica Aguilera, DaiWai M. Olson, Jane A. Anderson, Sean I. Savitz, Salvador C. Flores, Steven J. Warach, Charlotte E. Rhodes, Mark P. Goldberg, Nneka L. Ifejika
Summary: This study identified the barriers and facilitators to adopting tenecteplase (TNK) as a thrombolytic treatment for acute ischemic stroke (AIS) by conducting qualitative research with stroke clinicians in Texas. The findings suggest that providing evidence and identifying key change processes can help clinicians achieve consensus on adopting TNK for AIS treatment.
JOURNAL OF STROKE & CEREBROVASCULAR DISEASES
(2024)
Article
Neurosciences
Jeshma Jayan, Sunil K. Narayan, Yasmin Nesha Haniffa, Navin Kumar
Summary: This study investigated the effects of transcranial electrical and magnetic stimulation on somatosensory evoked potentials in chronic ischemic stroke patients, finding that the real tDCS and rTMS combination results in significant improvement and is safe for use.
JOURNAL OF STROKE & CEREBROVASCULAR DISEASES
(2024)
Article
Neurosciences
Phoebe M. Tran, Cenjing Zhu, William T. Harris II, Sajeesh K. Kamala Raghavan, Agricola Odoi, Liem Tran
Summary: This study assessed the geographic accessibility of stroke rehabilitation facilities in Tennessee. The study found that rural counties had significantly longer travel distances and times compared to urban counties. Counties with high and medium stroke prevalence also had higher travel times and distances compared to low stroke prevalence counties. Therefore, addressing transportation barriers and implementing tele-rehabilitation are crucial for improving access to stroke aftercare in these areas.
JOURNAL OF STROKE & CEREBROVASCULAR DISEASES
(2024)
Article
Neurosciences
Lili Xu, Shuaiyu Chen, Jing Xu, Yanyan Shi, Zhihang Huang, Meng Wang, Ziqiao Wei, Hui Cao, Junshan Zhou, Wei Wang, Mingyang Du
Summary: This study found that the Chinese Visceral Adiposity Index (CVAI) is positively correlated with 90-day poor outcome in Chinese ischemic stroke patients after endovascular thrombectomy (EVT).
JOURNAL OF STROKE & CEREBROVASCULAR DISEASES
(2024)
Article
Neurosciences
Guangying Wu, Shuhua Li, Min Luo, Xiaotian Li, Xinghua Zhu, Junhuai Zhang, Qian He, Qian Yang, Guojiang Zhao, Shasha Luo, Zhijie Yang
Summary: The study aimed to investigate the relationship between serum alkaline phosphatase (ALP) levels and the severity and prognosis of intracerebral hemorrhage (ICH). The results showed that serum ALP levels in ICH patients were significantly elevated and correlated with hematoma volume and Glasgow coma scale (GCS) score. High serum ALP levels may serve as a potential predictor for the severity and unfavorable prognosis of ICH.
JOURNAL OF STROKE & CEREBROVASCULAR DISEASES
(2024)