Pathway Editing Targets for Thiamine Biofortification in Rice Grains

With a free pass, CRISPR-edited plants reach market in record time

(2018) Emily Waltz   NATURE BIOTECHNOLOGY

The Revolution Continues: Newly Discovered Systems Expand the CRISPR-Cas Toolkit

(2017) Karthik Murugan et al.   MOLECULAR CELL

Significant enhancement of fatty acid composition in seeds of the allohexaploid, Camelina sativa , using CRISPR/Cas9 gene editing

(2017) Wen Zhi Jiang et al.   PLANT BIOTECHNOLOGY JOURNAL

High prevalence of thiamine (vitamin B1) deficiency in early childhood among a nationally representative sample of Cambodian women of childbearing age and their children

(2017) Kyly C. Whitfield et al.   PLoS Neglected Tropical Diseases

Development of japonica Photo-Sensitive Genic Male Sterile Rice Lines by Editing Carbon Starved Anther Using CRISPR/Cas9

(2016) Quanlin Li et al.   Journal of Genetics and Genomics

A Self-restricted CRISPR System to Reduce Off-target Effects

(2016) Yanhao Chen et al.   MOLECULAR THERAPY

Gene-edited CRISPR mushroom escapes US regulation

(2016) Emily Waltz   NATURE

Efficient targeted multiallelic mutagenesis in tetraploid potato (Solanum tuberosum) by transient CRISPR-Cas9 expression in protoplasts

(2016) Mariette Andersson et al.   PLANT CELL REPORTS

Long-Distance Transport of Thiamine (Vitamin B1) Is Concomitant with That of Polyamines

(2016) Jacopo Martinis et al.   PLANT PHYSIOLOGY

Reassessment of the Four Yield-related Genes Gn1a, DEP1, GS3, and IPA1 in Rice Using a CRISPR/Cas9 System

(2016) Meiru Li et al.   Frontiers in Plant Science

CRISPR/Cas9-mediated efficient and heritable targeted mutagenesis in tomato plants in the first and later generations

(2016) Changtian Pan et al.   Scientific Reports

Natures balancing act: examining biosynthesis de novo , recycling and processing damaged vitamin B metabolites

(2015) Maite Colinas et al.   CURRENT OPINION IN PLANT BIOLOGY

Improving folate (vitamin B9) stability in biofortified rice through metabolic engineering

(2015) Dieter Blancquaert et al.   NATURE BIOTECHNOLOGY

Enhancement of Thiamin Content inArabidopsis thalianaby Metabolic Engineering

(2015) Wei Dong et al.   PLANT AND CELL PHYSIOLOGY

TENOR: Database for Comprehensive mRNA-Seq Experiments in Rice

(2015) Yoshihiro Kawahara et al.   PLANT AND CELL PHYSIOLOGY

Cas9-Guide RNA Directed Genome Editing in Soybean

(2015) Zhongsen Li et al.   PLANT PHYSIOLOGY

Beriberi (Thiamine Deficiency) and High Infant Mortality in Northern Laos

(2015) Hubert Barennes et al.   PLoS Neglected Tropical Diseases

Regulatory uncertainty over genome editing

(2015) Huw D. Jones   Nature Plants

Establishing a CRISPR–Cas-like immune system conferring DNA virus resistance in plants

(2015) Xiang Ji et al.   Nature Plants

Fortification of rice: technologies and nutrients

(2014) Georg Steiger et al.   Annals of the New York Academy of Sciences

Béribéri du nourrisson : à propos d’un cas

(2014) P. Moulin et al.   ARCHIVES DE PEDIATRIE

Cas-OFFinder: a fast and versatile algorithm that searches for potential off-target sites of Cas9 RNA-guided endonucleases

(2014) S. Bae et al.   BIOINFORMATICS

Development and Applications of CRISPR-Cas9 for Genome Engineering

(2014) Patrick D. Hsu et al.   CELL

Thiamine Deficiency and Cardiac Dysfunction in Cambodian Infants

(2014) Samuel G. Porter et al.   JOURNAL OF PEDIATRICS

Simultaneous editing of three homoeoalleles in hexaploid bread wheat confers heritable resistance to powdery mildew

(2014) Yanpeng Wang et al.   NATURE BIOTECHNOLOGY

E-CRISP: fast CRISPR target site identification

(2014) Florian Heigwer et al.   NATURE METHODS

Thiamine deficiency in tachypnoeic Cambodian infants

(2014) Elizabeth M. Keating et al.   Paediatrics and International Child Health

Genome-wide analysis of endosperm-specific genes in rice

(2013) Dong-Ming Nie et al.   GENE

Effects of vitamin B6 metabolism on oncogenesis, tumor progression and therapeutic responses

(2013) L Galluzzi et al.   ONCOGENE

Orchestration of Thiamin Biosynthesis and Central Metabolism by Combined Action of the Thiamin Pyrophosphate Riboswitch and the Circadian Clock inArabidopsis

(2013) Samuel E. Bocobza et al.   PLANT CELL

Multiplex Genome Engineering Using CRISPR/Cas Systems

(2013) L. Cong et al.   SCIENCE

ZFN, TALEN, and CRISPR/Cas-based methods for genome engineering

(2013) Thomas Gaj et al.   TRENDS IN BIOTECHNOLOGY

Examining strategies to facilitate vitamin B1 biofortification of plants by genetic engineering

(2013) Lucille Pourcel et al.   Frontiers in Plant Science

RiceXPro Version 3.0: expanding the informatics resource for rice transcriptome

(2012) Yutaka Sato et al.   NUCLEIC ACIDS RESEARCH

Field transcriptome revealed critical developmental and physiological transitions involved in the expression of growth potential in japonica rice

(2011) Yutaka Sato et al.   BMC PLANT BIOLOGY

Genetic Diversity of Thiamin and Folate in Primitive Cultivated and Wild Potato (Solanum) Species

(2011) Aymeric Goyer et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Saccharomyces cerevisiae THI4p is a suicide thiamine thiazole synthase

(2011) Abhishek Chatterjee et al.   NATURE

PLEXdb: gene expression resources for plants and plant pathogens

(2011) S. Dash et al.   NUCLEIC ACIDS RESEARCH

Genome-wide transcriptome dissection of the rice root system: implications for developmental and physiological functions

(2011) Hinako Takehisa et al.   PLANT JOURNAL

Vitamin B6: A Molecule for Human Health?

(2010) Hanjo Hellmann et al.   MOLECULES

The CRISPR/Cas bacterial immune system cleaves bacteriophage and plasmid DNA

(2010) Josiane E. Garneau et al.   NATURE

RiceXPro: a platform for monitoring gene expression in japonica rice grown under natural field conditions

(2010) Y. Sato et al.   NUCLEIC ACIDS RESEARCH

OryzaExpress: An Integrated Database of Gene Expression Networks and Omics Annotations in Rice

(2010) Kazuki Hamada et al.   PLANT AND CELL PHYSIOLOGY

Thiamine Triphosphate Synthesis in Rat Brain Occurs in Mitochondria and Is Coupled to the Respiratory Chain

(2009) Marjorie Gangolf et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Transcriptome analysis of nitrogen-efficient rice over-expressing alanine aminotransferase

(2009) Perrin H. Beatty et al.   PLANT BIOTECHNOLOGY JOURNAL

Breaking the Code of DNA Binding Specificity of TAL-Type III Effectors

(2009) J. Boch et al.   SCIENCE

A Simple Cipher Governs DNA Recognition by TAL Effectors

(2009) M. J. Moscou et al.   SCIENCE

AtTHIC, a gene involved in thiamine biosynthesis in Arabidopsis thaliana

(2008) Danyu Kong et al.   CELL RESEARCH

Biofortified crops to alleviate micronutrient malnutrition

(2008) Jorge E Mayer et al.   CURRENT OPINION IN PLANT BIOLOGY

High-dose thiamine therapy for patients with type 2 diabetes and microalbuminuria: a randomised, double-blind placebo-controlled pilot study

(2008) N. Rabbani et al.   DIABETOLOGIA

Expression pattern and activity of six glutelin gene promoters in transgenic rice

(2008) L. Q. Qu et al.   JOURNAL OF EXPERIMENTAL BOTANY

Characteristics of Thiamin and Its Relevance to the Management of Heart Failure

(2008) Jennifer A. Wooley   NUTRITION IN CLINICAL PRACTICE

Enzymes that control the thiamine diphosphate pool in plant tissues. Properties of thiamine pyrophosphokinase and thiamine-(di)phosphate phosphatase purified from Zea mays seedlings

(2008) Maria Rapala-Kozik et al.   PLANT PHYSIOLOGY AND BIOCHEMISTRY

CRISPR Interference Limits Horizontal Gene Transfer in Staphylococci by Targeting DNA

(2008) Luciano A. Marraffini et al.   SCIENCE