Repurposing Auranofin, Ebselen, and PX-12 as Antimicrobial Agents Targeting the Thioredoxin System
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Title
Repurposing Auranofin, Ebselen, and PX-12 as Antimicrobial Agents Targeting the Thioredoxin System
Authors
Keywords
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Journal
Frontiers in Microbiology
Volume 9, Issue -, Pages -
Publisher
Frontiers Media SA
Online
2018-03-05
DOI
10.3389/fmicb.2018.00336
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Note: Only part of the references are listed.- Thioredoxin reductase from Toxoplasma gondii: an essential virulence effector with antioxidant function
- (2017) Junxin Xue et al. FASEB JOURNAL
- Repurposing Approach Identifies Auranofin with Broad Spectrum Antifungal Activity That Targets Mia40-Erv1 Pathway
- (2017) Shankar Thangamani et al. Frontiers in Cellular and Infection Microbiology
- Thioredoxin A Is Essential for Motility and Contributes to Host Infection of Listeria monocytogenes via Redox Interactions
- (2017) Changyong Cheng et al. Frontiers in Cellular and Infection Microbiology
- Screening a Commercial Library of Pharmacologically Active Small Molecules against Staphylococcus aureus Biofilms
- (2016) Nelson S. Torres et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- Ebselen and analogs as inhibitors of Bacillus anthracis thioredoxin reductase and bactericidal antibacterials targeting Bacillus species, Staphylococcus aureus and Mycobacterium tuberculosis
- (2016) Tomas N. Gustafsson et al. BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
- Identification of Ebsulfur Analogues with Broad-Spectrum Antifungal Activity
- (2016) Huy X. Ngo et al. ChemMedChem
- Inhibition of bacterial and fungal pathogens by the orphaned drug auranofin
- (2016) Beth Burgwyn Fuchs et al. Future Medicinal Chemistry
- Repurposing auranofin for the treatment of cutaneous staphylococcal infections
- (2016) Shankar Thangamani et al. INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
- Auranofin inactivates Trichomonas vaginalis thioredoxin reductase and is effective against trichomonads in vitro and in vivo
- (2016) Melissa Hopper et al. INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
- Repurposing auranofin as an antifungal: In vitro activity against a variety of medically important fungi
- (2016) Nathan P. Wiederhold et al. Virulence
- Mycobacterium tuberculosis Thioredoxin Reductase Is Essential for Thiol Redox Homeostasis but Plays a Minor Role in Antioxidant Defense
- (2016) Kan Lin et al. PLoS Pathogens
- Antibacterial activity and mechanism of action of auranofin against multi-drug resistant bacterial pathogens
- (2016) Shankar Thangamani et al. Scientific Reports
- Comparative Roles of the Two Helicobacter pylori Thioredoxins in Preventing Macromolecule Damage
- (2015) Lisa G. Kuhns et al. INFECTION AND IMMUNITY
- Auranofin efficacy against MDRStreptococcus pneumoniaeandStaphylococcus aureusinfections
- (2015) Leire Aguinagalde et al. JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
- Effect of the Putative Lithium Mimetic Ebselen on Brain Myo-Inositol, Sleep and Emotional Processing in Humans
- (2015) Nisha Singh et al. NEUROPSYCHOPHARMACOLOGY
- Auranofin exerts broad-spectrum bactericidal activities by targeting thiol-redox homeostasis
- (2015) Michael B. Harbut et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Strategy to enhance the therapeutic effect of doxorubicin in human hepatocellular carcinoma by selenocystine, a synergistic agent that regulates the ROS-mediated signaling
- (2015) Cundong Fan et al. Oncotarget
- Repurposing ebselen for treatment of multidrug-resistant staphylococcal infections
- (2015) Shankar Thangamani et al. Scientific Reports
- Drug repositioning: auranofin as a prospective antimicrobial agent for the treatment of severe staphylococcal infections
- (2014) Maria Iris Cassetta et al. BIOMETALS
- Auranofin and related heterometallic gold(I)–thiolates as potent inhibitors of methicillin-resistant Staphylococcus aureus bacterial strains
- (2014) Yozane Hokai et al. JOURNAL OF INORGANIC BIOCHEMISTRY
- Auranofin Is Highly Efficacious against Toxoplasma gondii In Vitro and in an In Vivo Experimental Model of Acute Toxoplasmosis
- (2014) Rosa M. Andrade et al. PLoS Neglected Tropical Diseases
- A Reprofiled Drug, Auranofin, Is Effective against Metronidazole-Resistant Giardia lamblia
- (2013) Noa Tejman-Yarden et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- High-Throughput Screening of a Collection of Known Pharmacologically Active Small Compounds for Identification of Candida albicans Biofilm Inhibitors
- (2013) Samuel A. Siles et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- The thioredoxin antioxidant system
- (2013) Jun Lu et al. FREE RADICAL BIOLOGY AND MEDICINE
- Candida albicans TRR1 heterozygotes show increased sensitivity to oxidative stress and decreased pathogenicity
- (2012) N. Z. Zaki African Journal of Microbiology Research
- Discovery and Biochemical Characterization of Plasmodium Thioredoxin Reductase Inhibitors from an Antimalarial Set
- (2012) Andrew J. Theobald et al. BIOCHEMISTRY
- Inhibition of bacterial thioredoxin reductase: an antibiotic mechanism targeting bacteria lacking glutathione
- (2012) Jun Lu et al. FASEB JOURNAL
- Fungal antioxidant pathways promote survival against neutrophils during infection
- (2012) Sixto M. Leal et al. JOURNAL OF CLINICAL INVESTIGATION
- A high-throughput drug screen for Entamoeba histolytica identifies a new lead and target
- (2012) Anjan Debnath et al. NATURE MEDICINE
- Identification of Thioredoxin Glutathione Reductase Inhibitors That Kill Cestode and Trematode Parasites
- (2012) Fabiana Ross et al. PLoS One
- A gold-containing drug against parasitic polyamine metabolism: the X-ray structure of trypanothione reductase from Leishmania infantum in complex with auranofin reveals a dual mechanism of enzyme inhibition
- (2011) Andrea Ilari et al. AMINO ACIDS
- Pyruvate:ferredoxin oxidoreductase and thioredoxin reductase are involved in 5-nitroimidazole activation while flavin metabolism is linked to 5-nitroimidazole resistance in Giardia lamblia
- (2011) D. Leitsch et al. JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
- A randomized phase II study of PX-12, an inhibitor of thioredoxin in patients with advanced cancer of the pancreas following progression after a gemcitabine-containing combination
- (2010) Ramesh K. Ramanathan et al. CANCER CHEMOTHERAPY AND PHARMACOLOGY
- Mapping the Catalytic Cycle ofSchistosoma mansoniThioredoxin Glutathione Reductase by X-ray Crystallography
- (2010) Francesco Angelucci et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Evaluation of the antifungal and plasma membrane H+-ATPase inhibitory action of ebselen and two ebselen analogs inS. cerevisiaecultures
- (2010) Blase Billack et al. JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY
- The flavin inhibitor diphenyleneiodonium renders Trichomonas vaginalis resistant to metronidazole, inhibits thioredoxin reductase and flavin reductase, and shuts off hydrogenosomal enzymatic pathways
- (2010) David Leitsch et al. MOLECULAR AND BIOCHEMICAL PARASITOLOGY
- Thioredoxin Regulates Multiple Hydrogen Peroxide-Induced Signaling Pathways in Candida albicans
- (2010) A. da Silva Dantas et al. MOLECULAR AND CELLULAR BIOLOGY
- Compartmentation of Redox Metabolism in Malaria Parasites
- (2010) Sebastian Kehr et al. PLoS Pathogens
- Trichomonas vaginalis: metronidazole and other nitroimidazole drugs are reduced by the flavin enzyme thioredoxin reductase and disrupt the cellular redox system. Implications for nitroimidazole toxicity and resistance
- (2009) David Leitsch et al. MOLECULAR MICROBIOLOGY
- How Thioredoxin Dissociates Its Mixed Disulfide
- (2009) Goedele Roos et al. PLoS Computational Biology
- Crystal structure of Saccharomyces cerevisiae cytoplasmic thioredoxin reductase Trr1 reveals the structural basis for species-specific recognition of thioredoxin
- (2008) Zhenyi Zhang et al. BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS
- New Organoselenium Compounds Active against Pathogenic Bacteria, Fungi and Viruses
- (2008) Magdalena Piętka-Ottlik et al. CHEMICAL & PHARMACEUTICAL BULLETIN
- New uses for old drugs. Auranofin, a clinically established antiarthritic metallodrug, exhibits potent antimalarial effects in vitro : Mechanistic and pharmacological implications
- (2008) Anna Rosa Sannella et al. FEBS LETTERS
- Platyhelminth Mitochondrial and Cytosolic Redox Homeostasis Is Controlled by a Single Thioredoxin Glutathione Reductase and Dependent on Selenium and Glutathione
- (2008) Mariana Bonilla et al. JOURNAL OF BIOLOGICAL CHEMISTRY
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