Dual leucine zipper kinase is required for mechanical allodynia and microgliosis after nerve injury

Sarm1/Myd88-5 Regulates Neuronal Intrinsic Immune Response to Traumatic Axonal Injuries

(2018) Qi Wang et al.   Cell Reports

Microglia emerge as central players in brain disease

(2017) Michael W Salter et al.   NATURE MEDICINE

Identification of spinal circuits involved in touch-evoked dynamic mechanical pain

(2017) Longzhen Cheng et al.   NATURE NEUROSCIENCE

Loss of dual leucine zipper kinase signaling is protective in animal models of neurodegenerative disease

(2017) Claire E. Le Pichon et al.   Science Translational Medicine

Dual leucine zipper kinase-dependent PERK activation contributes to neuronal degeneration following insult

(2017) Martin Larhammar et al.   eLife

Axon Degeneration Gated by Retrograde Activation of Somatic Pro-apoptotic Signaling

(2016) David J. Simon et al.   CELL

The Opioid Epidemic in the United States

(2016) Richard Gentry Wilkerson et al.   EMERGENCY MEDICINE CLINICS OF NORTH AMERICA

How neuroinflammation contributes to neurodegeneration

(2016) R. M. Ransohoff   SCIENCE

The serine protease inhibitor SerpinA3N attenuates neuropathic pain by inhibiting T cell–derived leukocyte elastase

(2015) Lucas Vicuña et al.   NATURE MEDICINE

Injured sensory neuron–derived CSF1 induces microglial proliferation and DAP12-dependent pain

(2015) Zhonghui Guan et al.   NATURE NEUROSCIENCE

Reduction of Neuropathic and Inflammatory Pain through Inhibition of the Tetrahydrobiopterin Pathway

(2015) Alban Latremoliere et al.   NEURON

iDISCO: A Simple, Rapid Method to Immunolabel Large Tissue Samples for Volume Imaging

(2014) Nicolas Renier et al.   CELL

Discovery of Dual Leucine Zipper Kinase (DLK, MAP3K12) Inhibitors with Activity in Neurodegeneration Models

(2014) Snahel Patel et al.   JOURNAL OF MEDICINAL CHEMISTRY

ZPK/DLK and MKK4 Form the Critical Gateway to Axotomy-Induced Motoneuron Death in Neonates

(2014) T. Itoh et al.   JOURNAL OF NEUROSCIENCE

DLK-dependent signaling is important for somal but not axonal degeneration of retinal ganglion cells following axonal injury

(2014) Kimberly A. Fernandes et al.   NEUROBIOLOGY OF DISEASE

Fractalkine/CX3CR1 signaling during neuropathic pain

(2014) Anna K. Clark et al.   Frontiers in Cellular Neuroscience

JUN regulates early transcriptional responses to axonal injury in retinal ganglion cells

(2013) Kimberly A. Fernandes et al.   EXPERIMENTAL EYE RESEARCH

Dual leucine zipper kinase is required for excitotoxicity-induced neuronal degeneration

(2013) Christine D. Pozniak et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Glia and pain: Is chronic pain a gliopathy?

(2013) Ru-Rong Ji et al.   PAIN

DLK initiates a transcriptional program that couples apoptotic and regenerative responses to axonal injury

(2013) T. A. Watkins et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Functional genomic screening identifies dual leucine zipper kinase as a key mediator of retinal ganglion cell death

(2013) D. S. Welsbie et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Conditioning Lesion Protects Axons from Degeneration via the Wallenda/DLK MAP Kinase Signaling Cascade

(2012) X. Xiong et al.   JOURNAL OF NEUROSCIENCE

P2X4R+ microglia drive neuropathic pain

(2012) Simon Beggs et al.   NATURE NEUROSCIENCE

Deconstructing the Neuropathic Pain Phenotype to Reveal Neural Mechanisms

(2012) Christian A. von Hehn et al.   NEURON

DLK induces developmental neuronal degeneration via selective regulation of proapoptotic JNK activity

(2011) Arundhati Sengupta Ghosh et al.   JOURNAL OF CELL BIOLOGY

Protein turnover of the Wallenda/DLK kinase regulates a retrograde response to axonal injury

(2010) Xin Xiong et al.   JOURNAL OF CELL BIOLOGY

Differential ATF3 expression in dorsal root ganglion neurons reveals the profile of primary afferents engaged by diverse noxious chemical stimuli

(2010) João M. Bráz et al.   PAIN

The DLK-1 Kinase Promotes mRNA Stability and Local Translation in C. elegans Synapses and Axon Regeneration

(2009) Dong Yan et al.   CELL

Cellular and Molecular Mechanisms of Pain

(2009) Allan I. Basbaum et al.   CELL

A dual leucine kinase–dependent axon self-destruction program promotes Wallerian degeneration

(2009) Bradley R Miller et al.   NATURE NEUROSCIENCE

Axon Regeneration Requires a Conserved MAP Kinase Pathway

(2009) M. Hammarlund et al.   SCIENCE