Fractalkine/CX3CR1 signaling during neuropathic pain

Activity of Adenosine Receptors Type 1 Is Required for CX3CL1-Mediated Neuroprotection and Neuromodulation in Hippocampal Neurons

(2014) C. Lauro et al.   JOURNAL OF IMMUNOLOGY

Peripheral Role of Cathepsin S in Th1 Cell-Dependent Transition of Nerve Injury-Induced Acute Pain to a Chronic Pain State

(2014) X. Zhang et al.   JOURNAL OF NEUROSCIENCE

Cathepsin S generates soluble CX3CL1 (fractalkine) in vascular smooth muscle cells

(2013) Urša Pečar Fonović et al.   BIOLOGICAL CHEMISTRY

Substituted 7-Amino-5-thio-thiazolo[4,5-d]pyrimidines as Potent and Selective Antagonists of the Fractalkine Receptor (CX3CR1)

(2013) Sofia Karlström et al.   JOURNAL OF MEDICINAL CHEMISTRY

Chloride extrusion enhancers as novel therapeutics for neurological diseases

(2013) Martin Gagnon et al.   NATURE MEDICINE

Neuron-glia crosstalk in health and disease: fractalkine and CX3CR1 take centre stage

(2013) G. K. Sheridan et al.   Open Biology

Neuropathic pain and cytokines: current perspectives

(2013) Marzia Malcangio et al.   Journal of Pain Research

Involvement of CX3CR1 in bone cancer pain through the activation of microglia p38 MAPK pathway in the spinal cord

(2012) Ji-Hua Hu et al.   BRAIN RESEARCH

Gabapentin reduces CX3CL1 signaling and blocks spinal microglial activation in monoarthritic rats

(2012) Jia-Le Yang et al.   Molecular Brain

In vivo structure/function and expression analysis of the CX3C chemokine fractalkine

(2011) K.-W. Kim et al.   BLOOD

Fractalkine/CX3CR1 and atherosclerosis

(2011) Hong Liu et al.   CLINICA CHIMICA ACTA

Fractalkine/CX3CR1 Signalling in Chronic Pain and Inflammation

(2011) Anna K. Clark et al.   CURRENT PHARMACEUTICAL BIOTECHNOLOGY

Clinical trial of the p38 MAP kinase inhibitor dilmapimod in neuropathic pain following nerve injury

(2011) Praveen Anand et al.   EUROPEAN JOURNAL OF PAIN

Microglial signalling mechanisms: Cathepsin S and Fractalkine

(2011) Anna K. Clark et al.   EXPERIMENTAL NEUROLOGY

Modulation of Peripheral Sensory Neurons by the Immune System: Implications for Pain Therapy

(2011) C. Stein et al.   PHARMACOLOGICAL REVIEWS

Intrathecal injection of anti-CX3CR1 neutralizing antibody delayed and attenuated pain facilitation in rat tibial bone cancer pain model

(2010) Qin Yin et al.   BEHAVIOURAL PHARMACOLOGY

Cathepsin S release from primary cultured microglia is regulated by the P2X7 receptor

(2010) Anna K. Clark et al.   GLIA

Reduced inflammatory and neuropathic pain and decreased spinal microglial response in fractalkine receptor (CX3CR1) knockout mice

(2010) Amelia A. Staniland et al.   JOURNAL OF NEUROCHEMISTRY

The neuro-immune balance in neuropathic pain: Involvement of inflammatory immune cells, immune-like glial cells and cytokines

(2010) Paul J. Austin et al.   JOURNAL OF NEUROIMMUNOLOGY

Fractalkine/CX3CL1: A Potential New Target for Inflammatory Diseases

(2010) B. A. Jones et al.   MOLECULAR INTERVENTIONS

Chemokines as Novel Therapeutic Targets for Inflammatory Bowel Disease

(2009) Miyuki Nishimura et al.   Annals of the New York Academy of Sciences

Fractalkine has anti-apoptotic and proliferative effects on human vascular smooth muscle cells via epidermal growth factor receptor signalling

(2009) Gemma E. White et al.   CARDIOVASCULAR RESEARCH

The Liberation of Fractalkine in the Dorsal Horn Requires Microglial Cathepsin S

(2009) A. K. Clark et al.   JOURNAL OF NEUROSCIENCE

P2X4-Receptor-Mediated Synthesis and Release of Brain-Derived Neurotrophic Factor in Microglia Is Dependent on Calcium and p38-Mitogen-Activated Protein Kinase Activation

(2009) T. Trang et al.   JOURNAL OF NEUROSCIENCE

Current Challenges in Glia-Pain Biology

(2009) Stephen B. McMahon et al.   NEURON

CX3CR1 Is Expressed by Human B Lymphocytes and Meditates CX3CL1 Driven Chemotaxis of Tonsil Centrocytes

(2009) Anna Corcione et al.   PLoS One

CX3CR1 is required for monocyte homeostasis and atherogenesis by promoting cell survival

(2008) L. Landsman et al.   BLOOD

Discovery of Orally Bioavailable Cathepsin S Inhibitors for the Reversal of Neuropathic Pain

(2008) Osamu Irie et al.   JOURNAL OF MEDICINAL CHEMISTRY

Up-Regulation of P2X4 Receptors in Spinal Microglia after Peripheral Nerve Injury Mediates BDNF Release and Neuropathic Pain

(2008) L. Ulmann et al.   JOURNAL OF NEUROSCIENCE