Transmission genetics of drug-resistant hepatitis C virus

Daclatasvir Prevents Hepatitis C Virus Infectivity by Blocking Transfer of the Viral Genome to Assembly Sites

(2017) Bertrand Boson et al.   GASTROENTEROLOGY

Origins of Combination Therapy for Tuberculosis: Lessons for Future Antimicrobial Development and Application

(2017) Christopher A. Kerantzas et al.   mBio

HCV NS5A replication complex inhibitors

(2016) Min Gao et al.   CURRENT OPINION IN PHARMACOLOGY

The Coding Region of the HCV Genome Contains a Network of Regulatory RNA Structures

(2016) Nathan Pirakitikulr et al.   MOLECULAR CELL

My Cousin, My Enemy: quasispecies suppression of drug resistance

(2016) Karla Kirkegaard et al.   Current Opinion in Virology

Exploiting Genetic Interference for Antiviral Therapy

(2016) Elizabeth J. Tanner et al.   PLoS Genetics

Coordination of Hepatitis C Virus Assembly by Distinct Regulatory Regions in Nonstructural Protein 5A

(2016) Margarita Zayas et al.   PLoS Pathogens

The R263K substitution in HIV-1 subtype C is more deleterious for integrase enzymatic function and viral replication than in subtype B

(2015) Thibault Mesplède et al.   AIDS

Treatment with ledipasvir and sofosbuvir improves patient-reported outcomes: Results from the ION-1, -2, and -3 clinical trials

(2015) Zobair M. Younossi et al.   HEPATOLOGY

L159F and V321A Sofosbuvir-Associated Hepatitis C Virus NS5B Substitutions

(2015) Evguenia S. Svarovskaia et al.   JOURNAL OF INFECTIOUS DISEASES

The Interface between Hepatitis B Virus Capsid Proteins Affects Self-Assembly, Pregenomic RNA Packaging, and Reverse Transcription

(2015) Zhenning Tan et al.   JOURNAL OF VIROLOGY

Resensitizing daclatasvir-resistant hepatitis C variants by allosteric modulation of NS5A

(2015) Jin-Hua Sun et al.   NATURE

Suppression of Drug Resistance in Dengue Virus

(2015) Roberto Mateo et al.   mBio

NS5A Domain 1 and Polyprotein Cleavage Kinetics Are Critical for Induction of Double-Membrane Vesicles Associated with Hepatitis C Virus Replication

(2015) Inés Romero-Brey et al.   mBio

Hepatitis C Virus RNA Replication Depends on Specific Cis- and Trans-Acting Activities of Viral Nonstructural Proteins

(2015) Teymur Kazakov et al.   PLoS Pathogens

Combining Oncolytic Virotherapy and Cytotoxic Therapies to Fight Cancer

(2014) Cristina Fillat et al.   CURRENT PHARMACEUTICAL DESIGN

Daclatasvir-Like Inhibitors of NS5A Block Early Biogenesis of Hepatitis C Virus–Induced Membranous Replication Factories, Independent of RNA Replication

(2014) Carola Berger et al.   GASTROENTEROLOGY

Coronaviruses Resistant to a 3C-Like Protease Inhibitor Are Attenuated for Replication and Pathogenesis, Revealing a Low Genetic Barrier but High Fitness Cost of Resistance

(2014) X. Deng et al.   JOURNAL OF VIROLOGY

Simeprevir plus sofosbuvir, with or without ribavirin, to treat chronic infection with hepatitis C virus genotype 1 in non-responders to pegylated interferon and ribavirin and treatment-naive patients: the COSMOS randomised study

(2014) Eric Lawitz et al.   LANCET

Treatment of HCV with ABT-450/r–Ombitasvir and Dasabuvir with Ribavirin

(2014) Jordan J. Feld et al.   NEW ENGLAND JOURNAL OF MEDICINE

Ledipasvir and Sofosbuvir for Untreated HCV Genotype 1 Infection

(2014) Nezam Afdhal et al.   NEW ENGLAND JOURNAL OF MEDICINE

Dominant drug targets suppress the emergence of antiviral resistance

(2014) Elizabeth J Tanner et al.   eLife

Human serum leads to differentiation of human hepatoma cells, restoration of very-low-density lipoprotein secretion, and a 1000-fold increase in HCV Japanese fulminant hepatitis type 1 titers

(2013) Rineke H.G. Steenbergen et al.   HEPATOLOGY

Genetically Altering the Thermodynamics and Kinetics of Hepatitis B Virus Capsid Assembly Has Profound Effects on Virus Replication in Cell Culture

(2013) Z. Tan et al.   JOURNAL OF VIROLOGY

Mutational and fitness landscapes of an RNA virus revealed through population sequencing

(2013) Ashley Acevedo et al.   NATURE

Understanding the hepatitis C virus life cycle paves the way for highly effective therapies

(2013) Troels K H Scheel et al.   NATURE MEDICINE

Novel therapies for hepatitis C — one pill fits all?

(2013) Michael P. Manns et al.   NATURE REVIEWS DRUG DISCOVERY

Sofosbuvir for Previously Untreated Chronic Hepatitis C Infection

(2013) Eric Lawitz et al.   NEW ENGLAND JOURNAL OF MEDICINE

Antiviral activity and resistance of HCV NS5A replication complex inhibitors

(2013) Min Gao   Current Opinion in Virology

Three-Dimensional Architecture and Biogenesis of Membrane Structures Associated with Hepatitis C Virus Replication

(2012) Inés Romero-Brey et al.   PLoS Pathogens

Discovery of Potent Hepatitis C Virus NS5A Inhibitors with Dimeric Structures

(2011) Julie A. Lemm et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Distinct Functions of NS5A in Hepatitis C Virus RNA Replication Uncovered by Studies with the NS5A Inhibitor BMS-790052

(2011) R. A. Fridell et al.   JOURNAL OF VIROLOGY

Boceprevir for Untreated Chronic HCV Genotype 1 Infection

(2011) Fred Poordad et al.   NEW ENGLAND JOURNAL OF MEDICINE

Boceprevir for Previously Treated Chronic HCV Genotype 1 Infection

(2011) Bruce R. Bacon et al.   NEW ENGLAND JOURNAL OF MEDICINE

Telaprevir for Previously Untreated Chronic Hepatitis C Virus Infection

(2011) Ira M. Jacobson et al.   NEW ENGLAND JOURNAL OF MEDICINE

A Disulfide-Bonded Dimer of the Core Protein of Hepatitis C Virus Is Important for Virus-Like Particle Production

(2010) Y. Kushima et al.   JOURNAL OF VIROLOGY

Viral Mutation Rates

(2010) R. Sanjuan et al.   JOURNAL OF VIROLOGY

Chemical genetics strategy identifies an HCV NS5A inhibitor with a potent clinical effect

(2010) Min Gao et al.   NATURE

Permissive Secondary Mutations Enable the Evolution of Influenza Oseltamivir Resistance

(2010) J. D. Bloom et al.   SCIENCE

The capsid-spacer peptide 1 Gag processing intermediate is a dominant-negative inhibitor of HIV-1 maturation

(2010) Mary Ann Checkley et al.   VIROLOGY

HIV-1 Gag Processing Intermediates Trans-dominantly Interfere with HIV-1 Infectivity

(2009) Barbara Müller et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Strongly Transdominant Mutation in the Human Immunodeficiency Virus Type 1 gag Gene Defines an Achilles Heel in the Virus Life Cycle

(2009) S.-K. Lee et al.   JOURNAL OF VIROLOGY