Resensitizing daclatasvir-resistant hepatitis C variants by allosteric modulation of NS5A

The crystal structure of NS5A domain 1 from genotype 1a reveals new clues to the mechanism of action for dimeric HCV inhibitors

(2014) Sebastian M. Lambert et al.   PROTEIN SCIENCE

Natural prevalence of NS5A polymorphisms in subjects infected with hepatitis C virus genotype 3 and their effects on the antiviral activity of NS5A inhibitors

(2013) Dennis Hernandez et al.   JOURNAL OF CLINICAL VIROLOGY

1209 TREATMENT-EMERGENT VARIANTS FOLLOWING 3 DAYS OF MONOTHERAPY WITH IDX719, A POTENT, PAN-GENOTYPIC NS5A INHIBITOR, IN SUBJECTS INFECTED WITH HCV GENOTYPES 1–4

(2013) J.F. McCarville et al.   JOURNAL OF HEPATOLOGY

NS5A inhibitors in the treatment of hepatitis C

(2013) Jean-Michel Pawlotsky   JOURNAL OF HEPATOLOGY

HCV NS5A Replication Complex Inhibitors. Part 4.1 Optimization for Genotype 1a Replicon Inhibitory Activity

(2013) Denis R. St. Laurent et al.   JOURNAL OF MEDICINAL CHEMISTRY

Discovery of Ledipasvir (GS-5885): A Potent, Once-Daily Oral NS5A Inhibitor for the Treatment of Hepatitis C Virus Infection

(2013) John O. Link et al.   JOURNAL OF MEDICINAL CHEMISTRY

Modeling shows that the NS5A inhibitor daclatasvir has two modes of action and yields a shorter estimate of the hepatitis C virus half-life

(2013) J. Guedj et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Characterizations of HCV NS5A replication complex inhibitors

(2013) Donald R. O'Boyle II et al.   VIROLOGY

Effect on Hepatitis C Virus Replication of Combinations of Direct-Acting Antivirals, Including NS5A Inhibitor Daclatasvir

(2012) Lenore A. Pelosi et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Global epidemiology of hepatitis C virus infection: New estimates of age-specific antibody to HCV seroprevalence

(2012) Khayriyyah Mohd Hanafiah et al.   HEPATOLOGY

Asymmetric Synthesis of α-Amino Acids by Reduction ofN-tert-Butanesulfinyl Ketimine Esters

(2011) Leleti Rajender Reddy et al.   JOURNAL OF ORGANIC CHEMISTRY

Resistance Analysis of the Hepatitis C Virus NS5A Inhibitor BMS-790052 in an In Vitro Replicon System

(2010) R. A. Fridell et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Chemical genetics strategy identifies an HCV NS5A inhibitor with a potent clinical effect

(2010) Min Gao et al.   NATURE

A Novel Small Molecule Inhibitor of Hepatitis C Virus Entry

(2010) Carl J. Baldick et al.   PLoS Pathogens

Crystal Structure of a Novel Dimeric Form of NS5A Domain I Protein from Hepatitis C Virus

(2009) R. A. Love et al.   JOURNAL OF VIROLOGY