Tregs in SLE: an Update

The serine/threonine protein phosphatase 2A controls autoimmunity

(2018) Amir Sharabi et al.   CLINICAL IMMUNOLOGY

Leptin levels in patients with systemic lupus erythematosus inversely correlate with regulatory T cell frequency

(2017) X Wang et al.   LUPUS

MicroRNA-21 deficiency protects from lupus-like autoimmunity in the chronic graft-versus-host disease model of systemic lupus erythematosus

(2016) Barry Garchow et al.   CLINICAL IMMUNOLOGY

TGF-β–Induced Regulatory T Cells Directly Suppress B Cell Responses through a Noncytotoxic Mechanism

(2016) Anping Xu et al.   JOURNAL OF IMMUNOLOGY

Phosphatase PP2A is requisite for the function of regulatory T cells

(2016) Sokratis A Apostolidis et al.   NATURE IMMUNOLOGY

Low-dose interleukin-2 treatment selectively modulates CD4+ T cell subsets in patients with systemic lupus erythematosus

(2016) Jing He et al.   NATURE MEDICINE

Leptin promotes systemic lupus erythematosus by increasing autoantibody production and inhibiting immune regulation

(2016) Elaine V. Lourenço et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Engagement of SLAMF3 enhances CD4+T-cell sensitivity to IL-2 and favors regulatory T-cell polarization in systemic lupus erythematosus

(2016) Denis Comte et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulatory T Cells in SLE: Biology and Use in Treatment

(2016) Sophia Giang et al.   Current Rheumatology Reports

Regulation of Effector Treg Cells in Murine Lupus

(2016) Uma Chandrasekaran et al.   Arthritis & Rheumatology

Editorial: Survive to Fight: Effector Treg Cells in Systemic Lupus Erythematosus

(2016) Antonio La Cava   Arthritis & Rheumatology

Low-dose interleukin-2 selectively corrects regulatory T cell defects in patients with systemic lupus erythematosus

(2015) Caroline von Spee-Mayer et al.   ANNALS OF THE RHEUMATIC DISEASES

A77 1726, the active metabolite of leflunomide, attenuates lupus nephritis by promoting the development of regulatory T cells and inhibiting IL-17-producing double negative T cells

(2015) Guilin Qiao et al.   CLINICAL IMMUNOLOGY

Sialyl Lewis x (CD15s) identifies highly differentiated and most suppressive FOXP3highregulatory T cells in humans

(2015) Makoto Miyara et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TGF-β3-expressing CD4+CD25−LAG3+ regulatory T cells control humoral immune responses

(2015) Tomohisa Okamura et al.   Nature Communications

MiR-125a targets effector programs to stabilize Treg-mediated immune homeostasis

(2015) Wen Pan et al.   Nature Communications

Regulatory T Cell Responses to High-Dose Methylprednisolone in Active Systemic Lupus Erythematosus

(2015) Alexis Mathian et al.   PLoS One

KN-93, an inhibitor of calcium/calmodulin-dependent protein kinase IV, promotes generation and function of Foxp3+regulatory T cells in MRL/lprmice

(2014) Tomohiro Koga et al.   AUTOIMMUNITY

Regulatory CD4+ T Cells Promote B Cell Anergy in Murine Lupus

(2014) Y. Liu et al.   JOURNAL OF IMMUNOLOGY

IL-2 Protects Lupus-Prone Mice from Multiple End-Organ Damage by Limiting CD4−CD8−IL-17–Producing T Cells

(2014) Masayuki Mizui et al.   JOURNAL OF IMMUNOLOGY

Mechanistic Target of Rapamycin Complex 1 Expands Th17 and IL-4+ CD4-CD8- Double-Negative T Cells and Contracts Regulatory T Cells in Systemic Lupus Erythematosus

(2014) H. Kato et al.   JOURNAL OF IMMUNOLOGY

Expansion of regulatory GITR+CD25low/-CD4+ T cells in systemic lupus erythematosus patients

(2014) Giuseppe Nocentini et al.   ARTHRITIS RESEARCH & THERAPY

Epigenetic dysregulation in systemic lupus erythematosus

(2013) Aijing Liu et al.   AUTOIMMUNITY

Major pathogenic steps in human lupus can be effectively suppressed by nucleosomal histone peptide epitope-induced regulatory immunity

(2013) Li Zhang et al.   CLINICAL IMMUNOLOGY

Blockade of Programmed Death-1 in Young (New Zealand Black x New Zealand White)F1 Mice Promotes the Suppressive Capacity of CD4+ Regulatory T Cells Protecting from Lupus-like Disease

(2013) M. Wong et al.   JOURNAL OF IMMUNOLOGY

Mechanistic Target of Rapamycin Activation Triggers IL-4 Production and Necrotic Death of Double-Negative T Cells in Patients with Systemic Lupus Erythematosus

(2013) Z.-W. Lai et al.   JOURNAL OF IMMUNOLOGY

The Tolerogenic Peptide, hCDR1, Down-Regulates the Expression of Interferon-α in Murine and Human Systemic Lupus Erythematosus

(2013) Zev Sthoeger et al.   PLoS One

CD4+Foxp3+ regulatory T cells prolong drug-induced disease remission in (NZBxNZW) F1 lupus mice

(2013) Olivia Weigert et al.   ARTHRITIS RESEARCH & THERAPY

Regulatory cell subsets in the control of autoantibody production related to systemic autoimmunity

(2012) Keishi Fujio et al.   ANNALS OF THE RHEUMATIC DISEASES

Foxp3+Helios+regulatory T cells are expanded in active systemic lupus erythematosus

(2012) Tobias Alexander et al.   ANNALS OF THE RHEUMATIC DISEASES

N-acetylcysteine reduces disease activity by blocking mammalian target of rapamycin in T cells from systemic lupus erythematosus patients: A randomized, double-blind, placebo-controlled trial

(2012) Zhi-Wei Lai et al.   ARTHRITIS AND RHEUMATISM

Oligodeoxynucleotides stabilize Helios-expressing Foxp3+ human T regulatory cells during in vitro expansion

(2012) Y. C. Kim et al.   BLOOD

miRNA in systemic lupus erythematosus

(2012) Gil Amarilyo et al.   CLINICAL IMMUNOLOGY

Cutting Edge: Fasting-Induced Hypoleptinemia Expands Functional Regulatory T Cells in Systemic Lupus Erythematosus

(2012) Y. Liu et al.   JOURNAL OF IMMUNOLOGY

Calcium/Calmodulin-Dependent Protein Kinase IV Suppresses IL-2 Production and Regulatory T Cell Activity in Lupus

(2012) T. Koga et al.   JOURNAL OF IMMUNOLOGY

Increased CD45RA+FoxP3low Regulatory T Cells with Impaired Suppressive Function in Patients with Systemic Lupus Erythematosus

(2012) Xiujun Pan et al.   PLoS One

Circulating microRNAs as candidate biomarkers in patients with systemic lupus erythematosus

(2012) Honglei Wang et al.   Translational Research

Polyclonal CD4+Foxp3+ Treg cells induce TGFβ-dependent tolerogenic dendritic cells that suppress the murine lupus-like syndrome

(2012) Qin Lan et al.   Journal of Molecular Cell Biology

Tolerance induced by anti-DNA Ig peptide in (NZB×NZW)F1 lupus mice impinges on the resistance of effector T cells to suppression by regulatory T cells

(2011) Yiyun Yu et al.   CLINICAL IMMUNOLOGY

Follicular regulatory T cells expressing Foxp3 and Bcl-6 suppress germinal center reactions

(2011) Yeonseok Chung et al.   NATURE MEDICINE

Foxp3+ follicular regulatory T cells control the germinal center response

(2011) Michelle A Linterman et al.   NATURE MEDICINE

CD4+CD25+ regulatory T cells control CD8+ T-cell effector differentiation by modulating IL-2 homeostasis

(2011) A. McNally et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Expression of Helios, an Ikaros Transcription Factor Family Member, Differentiates Thymic-Derived from Peripherally Induced Foxp3+ T Regulatory Cells

(2010) A. M. Thornton et al.   JOURNAL OF IMMUNOLOGY

Functional Delineation and Differentiation Dynamics of Human CD4+ T Cells Expressing the FoxP3 Transcription Factor

(2009) Makoto Miyara et al.   IMMUNITY

Cutting Edge: Regulatory T Cells Directly Suppress B Cells in Systemic Lupus Erythematosus

(2009) N. Iikuni et al.   JOURNAL OF IMMUNOLOGY

Homeostatic imbalance of regulatory and effector T cells due to IL-2 deprivation amplifies murine lupus

(2009) J. Y. Humrich et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA