Engagement of SLAMF3 enhances CD4+T-cell sensitivity to IL-2 and favors regulatory T-cell polarization in systemic lupus erythematosus

Low-dose interleukin-2 selectively corrects regulatory T cell defects in patients with systemic lupus erythematosus

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Rapid induction of clinical remission by low-dose interleukin-2 in a patient with refractory SLE

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A polymorphism in a phosphotyrosine signalling motif of CD229 (Ly9, SLAMF3) alters SH2 domain binding and T-cell activation

(2015) Stefanie Margraf et al.   IMMUNOLOGY

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Selective Loss of Signaling Lymphocytic Activation Molecule Family Member 4-Positive CD8+ T Cells Contributes to the Decreased Cytotoxic Cell Activity in Systemic Lupus Erythematosus

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KN-93, an inhibitor of calcium/calmodulin-dependent protein kinase IV, promotes generation and function of Foxp3+regulatory T cells in MRL/lprmice

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Role of SLAM Family Receptors and Specific Adapter SAP in Innate-Like Lymphocytes

(2014) Xavier Romero et al.   CRITICAL REVIEWS IN IMMUNOLOGY

CaMK4-dependent activation of AKT/mTOR and CREM-α underlies autoimmunity-associated Th17 imbalance

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Phenotypic and Functional Analysis of CD4+CD25-Foxp3+ T Cells in Patients with Systemic Lupus Erythematosus

(2014) M. Bonelli et al.   JOURNAL OF IMMUNOLOGY

IL-2 Protects Lupus-Prone Mice from Multiple End-Organ Damage by Limiting CD4−CD8−IL-17–Producing T Cells

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Improved vectors and genome-wide libraries for CRISPR screening

(2014) Neville E Sanjana et al.   NATURE METHODS

Lupus-Prone Mice Fail to Raise Antigen-Specific T Cell Responses to Intracellular Infection

(2014) Linda A. Lieberman et al.   PLoS One

Regulatory T Cells as Immunotherapy

(2014) Benjamin D. Singer et al.   Frontiers in Immunology

Interleukin-2 at the Crossroads of Effector Responses, Tolerance, and Immunotherapy

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RNA-guided gene activation by CRISPR-Cas9–based transcription factors

(2013) Pablo Perez-Pinera et al.   NATURE METHODS

Splicing factor SF2/ASF rescues IL-2 production in T cells from systemic lupus erythematosus patients by activating IL-2 transcription

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Ly9 (CD229) Cell-Surface Receptor is Crucial for the Development of Spontaneous Autoantibody Production to Nuclear Antigens

(2013) Jose de Salort et al.   Frontiers in Immunology

Induced CD4+Foxp3+ Regulatory T Cells in Immune Tolerance

(2012) Angelina M. Bilate et al.   Annual Review of Immunology

SLAM Family Receptors and SAP Adaptors in Immunity

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Increased Expression of SLAM Receptors SLAMF3 and SLAMF6 in Systemic Lupus Erythematosus T Lymphocytes Promotes Th17 Differentiation

(2011) M. Chatterjee et al.   JOURNAL OF IMMUNOLOGY

Systemic Lupus Erythematosus

(2011) George C. Tsokos   NEW ENGLAND JOURNAL OF MEDICINE

Regulatory T-Cell Responses to Low-Dose Interleukin-2 in HCV-Induced Vasculitis

(2011) David Saadoun et al.   NEW ENGLAND JOURNAL OF MEDICINE

Interleukin-2 and Regulatory T Cells in Graft-versus-Host Disease

(2011) John Koreth et al.   NEW ENGLAND JOURNAL OF MEDICINE

The IL-2 Defect in Systemic Lupus Erythematosus Disease Has an Expansive Effect on Host Immunity

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Genetic susceptibility to systemic lupus erythematosus in the genomic era

(2010) Yun Deng et al.   Nature Reviews Rheumatology

Homeostatic imbalance of regulatory and effector T cells due to IL-2 deprivation amplifies murine lupus

(2009) J. Y. Humrich et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Reduced CD4+,CD25− T cell sensitivity to the suppressive function of CD4+,CD25high,CD127−/lowregulatory T cells in patients with active systemic lupus erythematosus

(2008) Ram Kumar Chowdary Venigalla et al.   ARTHRITIS AND RHEUMATISM

Association of LY9 in UK and Canadian SLE families

(2008) D S Cunninghame Graham et al.   GENES AND IMMUNITY

STAT5-signaling cytokines regulate the expression of FOXP3 in CD4+CD25+ regulatory T cells and CD4+CD25− effector T cells

(2008) Laura Passerini et al.   INTERNATIONAL IMMUNOLOGY

Quantitative and qualitative deficiencies of regulatory T cells in patients with systemic lupus erythematosus (SLE)

(2008) M. Bonelli et al.   INTERNATIONAL IMMUNOLOGY