The new 6q27 tumor suppressor DACT2, frequently silenced by CpG methylation, sensitizes nasopharyngeal cancer cells to paclitaxel and 5-FU toxicity via β-catenin/Cdc25c signaling and G2/M arrest

Upregulation of DACT2 suppresses proliferation and enhances apoptosis of glioma cell via inactivation of YAP signaling pathway

(2017) Ying Tan et al.   Cell Death & Disease

The G2 checkpoint-a node-based molecular switch

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Methylation of DACT2 promotes breast cancer development by activating Wnt signaling

(2017) Jingyi Li et al.   Scientific Reports

Global cancer statistics, 2012

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Methylation of PLCD1 and adenovirus-mediated PLCD1 overexpression elicits a gene therapy effect on human breast cancer

(2015) Haixi Mu et al.   EXPERIMENTAL CELL RESEARCH

Protocadherin20Acts as a Tumor Suppressor Gene: Epigenetic Inactivation in Nasopharyngeal Carcinoma

(2015) Tao Chen et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

WNT/β-Catenin Signaling Regulates Multiple Steps of Myogenesis by Regulating Step-Specific Targets

(2015) Akiko Suzuki et al.   MOLECULAR AND CELLULAR BIOLOGY

Matrine inhibits the migratory and invasive properties of nasopharyngeal carcinoma cells

(2015) BIN SUN et al.   Molecular Medicine Reports

Characterization of the nasopharyngeal carcinoma methylome identifies aberrant disruption of key signaling pathways and methylated tumor suppressor genes

(2015) Lili Li et al.   Epigenomics

DACT2 is a functional tumor suppressor through inhibiting Wnt/β-catenin pathway and associated with poor survival in colon cancer

(2014) S Wang et al.   ONCOGENE

Methylation of DACT2 Promotes Papillary Thyroid Cancer Metastasis by Activating Wnt Signaling

(2014) Zhiyan Zhao et al.   PLoS One

DACT2 Is a Candidate Tumor Suppressor and Prognostic Marker in Esophageal Squamous Cell Carcinoma

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Epigenetic identification of receptor tyrosine kinase-like orphan receptor 2 as a functional tumor suppressor inhibiting β-catenin and AKT signaling but frequently methylated in common carcinomas

(2013) Lili Li et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Epigenetic regulation of the Wnt signaling inhibitorDACT2in human hepatocellular carcinoma

(2013) Xiaomei Zhang et al.   Epigenetics

Reduced expression of DACT2 promotes hepatocellular carcinoma progression: involvement of methylation-mediated gene silencing

(2013) Sheng Gao et al.   World Journal of Surgical Oncology

Protocadherin8 is a functional tumor suppressor frequently inactivated by promoter methylation in nasopharyngeal carcinoma

(2012) Dan He et al.   EUROPEAN JOURNAL OF CANCER PREVENTION

Epigenetic regulation of DACT2, a key component of the Wnt signalling pathway in human lung cancer

(2012) Yan Jia et al.   JOURNAL OF PATHOLOGY

The Ubiquitin Peptidase UCHL1 Induces G0/G1 Cell Cycle Arrest and Apoptosis Through Stabilizing p53 and Is Frequently Silenced in Breast Cancer

(2012) Tingxiu Xiang et al.   PLoS One

Development of a Quantitative Methylation-Specific Polymerase Chain Reaction Method for Monitoring Beta Cell Death in Type 1 Diabetes

(2012) Mohamed I. Husseiny et al.   PLoS One

Epigenetic disruption of cell signaling in nasopharyngeal carcinoma

(2011) Li-Li Li et al.   Chinese Journal of Cancer

The Tumor Suppressor UCHL1 Forms a Complex with p53/MDM2/ARF to Promote p53 Signaling and Is Frequently Silenced in Nasopharyngeal Carcinoma

(2010) L. Li et al.   CLINICAL CANCER RESEARCH

Quantitative Reconstitution of Mitotic CDK1 Activation in Somatic Cell Extracts

(2010) Richard W. Deibler et al.   MOLECULAR CELL

Phospholipase C delta 1 is a novel 3p22.3 tumor suppressor involved in cytoskeleton organization, with its epigenetic silencing correlated with high-stage gastric cancer

(2009) X -T Hu et al.   ONCOGENE