Bioprocessing of Recombinant CHO-K1, CHO-DG44, and CHO-S: CHO Expression Hosts Favor Either mAb Production or Biomass Synthesis

Modulating IgG effector function by Fc glycan engineering

(2017) Tiezheng Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Genetic analyses of Per.C6 cell clones producing a therapeutic monoclonal antibody regarding productivity and long-term stability

(2016) Lilian Rumi Tsuruta et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Advances in recombinant antibody manufacturing

(2016) Renate Kunert et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Proteomic differences in recombinant CHO cells producing two similar antibody fragments

(2016) Wolfgang Sommeregger et al.   BIOTECHNOLOGY AND BIOENGINEERING

Benchmarking of commercially available CHO cell culture media for antibody production

(2015) David Reinhart et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

A global RNA-seq-driven analysis of CHO host and production cell lines reveals distinct differential expression patterns of genes contributing to recombinant antibody glycosylation

(2015) Jennifer D. Könitzer et al.   Biotechnology Journal

Antibody Glycosylation and Its Impact on the Pharmacokinetics and Pharmacodynamics of Monoclonal Antibodies and Fc-Fusion Proteins

(2015) Liming Liu   JOURNAL OF PHARMACEUTICAL SCIENCES

Heterologous protein production using euchromatin-containing expression vectors in mammalian cells

(2015) Katalin Zboray et al.   NUCLEIC ACIDS RESEARCH

A global RNA-seq-driven analysis of CHO host and production cell lines reveals distinct differential expression patterns of genes contributing to recombinant antibody glycosylation

(2015) Jennifer D. Könitzer et al.   Biotechnology Journal

In search of expression bottlenecks in recombinant CHO cell lines—a case study

(2014) David Reinhart et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Influence of glycosylation pattern on the molecular properties of monoclonal antibodies

(2014) Kai Zheng et al.   mAbs

Transcriptome dynamics of transgene amplification in Chinese hamster ovary cells

(2013) Nandita Vishwanathan et al.   BIOTECHNOLOGY AND BIOENGINEERING

CHO cell line specific prediction and control of recombinant monoclonal antibodyN-glycosylation

(2013) Rhian K. Grainger et al.   BIOTECHNOLOGY AND BIOENGINEERING

Chinese hamster ovary K1 host cell enables stable cell line development for antibody molecules which are difficult to express in DUXB11-derived dihydrofolate reductase deficient host cell

(2013) Zhilan Hu et al.   BIOTECHNOLOGY PROGRESS

Transgene copy number comparison in recombinant mammalian cell lines: critical reflection of quantitative real-time PCR evaluation

(2013) Wolfgang Sommeregger et al.   CYTOTECHNOLOGY

Removal of a C-terminal serine residue proximal to the inter-chain disulfide bond of a human IgG1 lambda light chain mediates enhanced antibody stability and antibody dependent cell-mediated cytotoxicity

(2013) Yang Shen et al.   mAbs

Engineering a therapeutic IgG molecule to address cysteinylation, aggregation and enhance thermal stability and expression

(2013) Andrew Buchanan et al.   mAbs

Genomic landscapes of Chinese hamster ovary cell lines as revealed by the Cricetulus griseus draft genome

(2013) Nathan E Lewis et al.   NATURE BIOTECHNOLOGY

Exploration of BAC versus plasmid expression vectors in recombinant CHO cells

(2012) Alexander Mader et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Quantitative evaluation of fucose reducing effects in a humanized antibody on Fcγ receptor binding and antibody-dependent cell-mediated cytotoxicity activities

(2012) Shan Chung et al.   mAbs

Production, characterization and pharmacokinetic properties of antibodies with N-linked Mannose-5 glycans

(2012) Marcella Yu et al.   mAbs

Fast analysis of recombinant monoclonal antibodies using IdeS proteolytic digestion and electrospray mass spectrometry

(2011) Guillaume Chevreux et al.   ANALYTICAL BIOCHEMISTRY

Genomics in mammalian cell culture bioprocessing

(2011) Diane M. Wuest et al.   BIOTECHNOLOGY ADVANCES

A mechanistic understanding of production instability in CHO cell lines expressing recombinant monoclonal antibodies

(2011) Minsoo Kim et al.   BIOTECHNOLOGY AND BIOENGINEERING

Modulation of antibody galactosylation through feeding of uridine, manganese chloride, and galactose

(2011) Michael J. Gramer et al.   BIOTECHNOLOGY AND BIOENGINEERING

Dynamic Changes in the Copy Number of Pluripotency and Cell Proliferation Genes in Human ESCs and iPSCs during Reprogramming and Time in Culture

(2011) Louise C. Laurent et al.   Cell Stem Cell

First CHO genome

(2011) Florian M Wurm et al.   NATURE BIOTECHNOLOGY

The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line

(2011) Xun Xu et al.   NATURE BIOTECHNOLOGY

Oxidative protein folding in the endoplasmic reticulum: Tight links to the mitochondria-associated membrane (MAM)

(2010) Thomas Simmen et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

DNA methylation contributes to loss in productivity of monoclonal antibody-producing CHO cell lines

(2010) Yuansheng Yang et al.   JOURNAL OF BIOTECHNOLOGY

High-resolution DNA analysis of human embryonic stem cell lines reveals culture-induced copy number changes and loss of heterozygosity

(2010) Elisa Närvä et al.   NATURE BIOTECHNOLOGY

The impact of intragenic CpG content on gene expression

(2010) Asli Petra Bauer et al.   NUCLEIC ACIDS RESEARCH

Auditioning of CHO host cell lines using the artificial chromosome expression (ACE) technology

(2009) Malcolm L. Kennard et al.   BIOTECHNOLOGY AND BIOENGINEERING

Transcriptome and proteome analysis of Chinese hamster ovary cells under low temperature and butyrate treatment

(2009) Anne Kantardjieff et al.   JOURNAL OF BIOTECHNOLOGY

Glycosylation as a strategy to improve antibody-based therapeutics

(2009) Roy Jefferis   NATURE REVIEWS DRUG DISCOVERY

The absence of effect of gene copy number and mRNA level on the amount of mAb secretion from mammalian cells

(2008) Hannes Reisinger et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

A clone screening method using mRNA levels to determine specific productivity and product quality for monoclonal antibodies

(2008) Christina J. Lee et al.   BIOTECHNOLOGY AND BIOENGINEERING

Glycosylation of Recombinant Antibody Therapeutics

(2005) Royston Jefferis   BIOTECHNOLOGY PROGRESS