Recent Developments and Perspectives in the Asymmetric Mannich Reaction

Synthesis of substituted benzofurans and indoles by Zn-catalyzed tandem Sonogashira-cyclization strategy

(2017) Amrutha P. Thankachan et al.   TETRAHEDRON LETTERS

A new approach to the asymmetric Mannich reaction catalyzed by chiral N,N′-dioxide–metal complexes

(2017) Xiangjin Lian et al.   Chemical Science

Catalytic Asymmetric Mannich Reaction of Isatin-derived N -Boc Imines with Malononitrile by Bis(imidazolidine)-derived Pincer Rh Complex

(2017) Takayoshi Arai et al.   ChemistrySelect

A novel Zinc-catalyzed Cadiot-Chodkiewicz cross-coupling reaction of terminal alkynes with 1-bromoalkynes in ethanol solvent

(2017) K. Keerthi Krishnan et al.   Molecular Catalysis

Direct Catalytic Asymmetric Mannich Reaction with Dithiomalonates as Excellent Mannich Donors: Organocatalytic Synthesis of (R )-Sitagliptin

(2016) Han Yong Bae et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

First example of an organocatalytic asymmetric Mannich reaction between aldimines of glycinates and sulphonyl imines

(2016) Lei Wu et al.   CANADIAN JOURNAL OF CHEMISTRY

Asymmetric Mannich Reaction of Aryl Methyl Ketones with Cyclic Imines Benzo[e][1,2,3]oxathiazine 2,2-Dioxides Catalyzed by Cinchona Alkaloid-based Primary Amines

(2016) Xiao-Yu Cui et al.   Chemistry-An Asian Journal

The need for fundamental reforms in the pain research field to develop innovative drugs

(2016) Yukinori Nagakura   Expert Opinion on Drug Discovery

Organocatalytic Asymmetric Mannich Reaction of 3-Hydroxyoxindoles/3-Aminooxindoles with in Situ Generated N-Boc-Protected Aldimines for the Synthesis of Vicinal Oxindole–Diamines/Amino Alcohols

(2016) Jing Shan et al.   JOURNAL OF ORGANIC CHEMISTRY

Asymmetric Mannich Reaction of Isatin-Based Ketimines with α-Diazomethylphosphonates Catalyzed by Chiral Silver Phosphate

(2016) Jing Chen et al.   ORGANIC LETTERS

Biocatalytic asymmetric Mannich reaction of ketimines using wheat germ lipase

(2016) Ling-Ling Wu et al.   Catalysis Science & Technology

Asymmetric Mannich reaction: highly enantioselective synthesis of 3-amino-oxindoles via chiral squaramide based H-bond donor catalysis

(2016) Kadiyala Srinivasa Rao et al.   RSC Advances

l-Proline-functionalized Fe3O4nanoparticles as a novel magnetic chiral catalyst for the direct asymmetric Mannich reaction

(2015) Javad Safaei-Ghomi et al.   APPLIED ORGANOMETALLIC CHEMISTRY

Chiral Bis(imidazolidine)-Derived NCN Pincer Rh Complex for Catalytic Asymmetric Mannich Reaction of Malononitrile withN-Boc Imines

(2015) Takayoshi Arai et al.   CHEMISTRY-A EUROPEAN JOURNAL

Synthesis, Characterization and Application of Some Axially Chiral Binaphthyl Phosphoric Acids in Asymmetric Mannich Reaction

(2015) Yuanyong Yao et al.   CHINESE JOURNAL OF CHEMISTRY

Mannich bases in medicinal chemistry and drug design

(2015) Gheorghe Roman   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Enzyme-catalyzed asymmetric Mannich reaction using acylase from Aspergillus melleus

(2015) Zhi Guan et al.   JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC

Catalytic Asymmetric Construction of Vicinal Tetrasubstituted Stereocenters by the Mannich Reaction of Linear α-Substituted Monothiomalonates with Isatin N-Boc Ketimines

(2015) Teng Liu et al.   JOURNAL OF ORGANIC CHEMISTRY

Highly Regio-, Diastereo-, and Enantioselective Mannich Reaction of Allylic Ketones and Cyclic Ketimines: Access to Chiral Benzosultam

(2015) Baokun Qiao et al.   ORGANIC LETTERS

Bifunctional Amino Sulfonohydrazide Catalyzed Direct Asymmetric Mannich Reaction of Cyclic Ketimines with Ketones: Highly Diastereo- and Enantioselective Construction of Quaternary Carbon Stereocenters

(2015) Sheng Zhang et al.   ORGANIC LETTERS

Nickel-Catalyzed Enantioselective Friedel–Crafts Alkylation of Indoles with β,β-Disubstituted Nitroalkenes

(2015) Yi-Xia Jia et al.   SYNLETT

Asymmetric synthesis of syn-propargylamines and unsaturated β-amino acids under Brønsted base catalysis

(2015) Yingcheng Wang et al.   Nature Communications

Asymmetric Dual-Reagent Catalysis: Mannich-type Reactions Catalyzed by Ion Pair

(2014) Hong-Yu Wang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Asymmetric Mannich Reaction of Malonates with Aldimines Using YbIII-Pybox Complexes Supported on Self-Assembled Organic-Inorganic Hybrid Silica with an Imidazolium Framework

(2014) Babak Karimi et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Organocatalyzed Enantioselective Mannich Reaction of Pyrazoleamides with Isatin-Derived Ketimines

(2014) Tian-Ze Li et al.   JOURNAL OF ORGANIC CHEMISTRY

Primary amino acid catalyzed asymmetric intramolecular Mannich reaction for the synthesis of 2-aryl-2,3-dihydro-4-quinolones

(2014) Buddhadeb Mondal et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Asymmetric Phase-Transfer Catalysts Bearing Multiple Hydrogen-Bonding Donors: Highly Efficient Catalysts for Enantio- and Diastereoselective Nitro-Mannich Reaction of Amidosulfones

(2014) Bin Wang et al.   ORGANIC LETTERS

Remote chirality control based on the organocatalytic asymmetric Mannich reaction of α-thio acetaldehydes

(2013) Taichi Kano et al.   CHEMICAL COMMUNICATIONS

Asymmetric Mannich Reaction of α-Keto Imines Catalyzed by Diarylprolinol Silyl Ether

(2013) Yujiro Hayashi et al.   CHEMISTRY-A EUROPEAN JOURNAL

Cyclopropenimine-Catalyzed Enantioselective Mannich Reactions of tert-Butyl Glycinates with N-Boc-Imines

(2013) Jeffrey S. Bandar et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Disulfonimide-Catalyzed Asymmetric Synthesis of β3-Amino Esters Directly from N-Boc-Amino Sulfones

(2013) Qinggang Wang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Asymmetric Mannich reaction between (S)-N-(tert-butanesulfinyl)-3,3,3-trifluoroacetaldimine and malonic acid derivatives. Stereodivergent synthesis of (R)- and (S)-3-amino-4,4,4-trifluorobutanoic acids

(2013) Norio Shibata et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Asymmetric One-Pot Sequential Mannich/Hydroamination Reaction by Organo- and Gold Catalysts: Synthesis of Spiro[pyrrolidin-3,2′-oxindole] Derivatives

(2013) Xianjie Chen et al.   ORGANIC LETTERS

Recent Advances in Metal-Catalyzed Asymmetric Mannich Reactions

(2013) Babak Karimi et al.   SYNTHESIS-STUTTGART

A general approach for the asymmetric synthesis of densely substituted piperidines and fully substituted piperidinones employing the asymmetric Mannich reaction as key step

(2013) Ainara Iza et al.   RSC Advances

Catalytic Asymmetric Cross-Aza-Benzoin Reactions of Aliphatic Aldehydes withN-Boc-Protected Imines

(2012) Daniel A. DiRocco et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

3-Bromooxindoles as nucleophiles in asymmetric organocatalytic Mannich reactions with N-Ts-imines

(2012) Jianhao Li et al.   CHEMICAL COMMUNICATIONS

Diastereoselective three-component Mannich reaction catalyzed by silica-supported ferric hydrogensulfate

(2012) Hossein Eshghi et al.   MONATSHEFTE FUR CHEMIE

A New Family of Cinchona-Derived Bifunctional Asymmetric Phase-Transfer Catalysts: Application to the Enantio- and Diastereoselective Nitro-Mannich Reaction of Amidosulfones

(2012) Kayli M. Johnson et al.   ORGANIC LETTERS

A facile direct anti-selective catalytic asymmetric Mannich reaction of aldehydes with preformed N-Boc and N-Cbz imines

(2011) Yong-Ming Chuan et al.   CHEMICAL COMMUNICATIONS

Catalytic Enantioselective Formation of C−C Bonds by Addition to Imines and Hydrazones: A Ten-Year Update

(2011) Shu̅ Kobayashi et al.   CHEMICAL REVIEWS

A facile 1,3-dipolar cycloaddition of azomethine ylides to 2-arylidene-1,3-indanediones: Synthesis of dispiro-oxindolylpyrrolothiazoles and their antimycobacterial evaluation

(2010) Shanmugavel Uma Maheswari et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Recent advances in the catalytic asymmetric synthesis of β-amino acids

(2010) Barbara Weiner et al.   CHEMICAL SOCIETY REVIEWS

Nuclease p1: a new biocatalyst for direct asymmetric aldol reaction under solvent-free conditions

(2010) Hai-Hong Li et al.   GREEN CHEMISTRY

The lipase-catalyzed asymmetric C–C Michael addition

(2010) Jian-Feng Cai et al.   JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC

Spiroindolones, a Potent Compound Class for the Treatment of Malaria

(2010) M. Rottmann et al.   SCIENCE

Biocatalytic promiscuity: the first lipase-catalysed asymmetric aldol reaction

(2008) Chao Li et al.   GREEN CHEMISTRY

Synthesis of pharmaceutically active compounds containing a disubstituted piperidine framework

(2007) Sara Källström et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Organocatalysed asymmetric Mannich reactions

(2007) Jorge M. M. Verkade et al.   CHEMICAL SOCIETY REVIEWS