Journal
CHINESE JOURNAL OF CHEMISTRY
Volume 33, Issue 5, Pages 601-609Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/cjoc.201500017
Keywords
asymmetric organocatalysis; BrOnsted acid; Mannich reaction; binaphthyl phosphoric acids
Categories
Funding
- Natural Science Foundations of Guizhou Province [KY (2014)317, KY (2011)232]
- Educational Ministry Foundation of Guizhou Province [KY (2012)018]
Ask authors/readers for more resources
Two novel chiral Br?nsted acids 3b and 3c were prepared without involving the complexity of Suzuki coupling. Catalyst 3c bearing two additional hydroxyl groups at 3 and 3 positions of axially chiral 1,1-binaphthalene-2,2-diol phosphoric acid was applied in a model Mannich reaction to afford -amino ester in high yield (92%) and enantiomeric excess (91%) at low reacting temperature of -40 degrees C. In addition, those -amino ester derivatives with high yields and excellent enatioselectivities were obtained in the presence of catalyst 3c under the above condition.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available