Recent Developments and Perspectives in the Asymmetric Mannich Reaction

The asymmetric Mannich reaction is a very important method for C-C bond formation, and it is the classical method for the preparation of beta-amino ketones and aldehydes. The resulting beta-amino carbonyl compounds are widely found in nature, which attests to the importance of this reaction. This Focus Review provides an overview of asymmetric Mannich reactions, the various catalysts that have been used, and its applications, for papers published since 2013.