Hfq chaperone brings speed dating to bacterial sRNA

New aspects of RNA-based regulation by Hfq and its partner sRNAs

(2018) Kumari Kavita et al.   CURRENT OPINION IN MICROBIOLOGY

Hfq links translation repression to stress-induced mutagenesis in E. coli

(2017) Jiandong Chen et al.   GENES & DEVELOPMENT

RNA-based recognition and targeting: sowing the seeds of specificity

(2017) Stanislaw A. Gorski et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Interplay between the catabolite repression control protein Crc, Hfq and RNA in Hfq-dependent translational regulation in Pseudomonas aeruginosa

(2017) Elisabeth Sonnleitner et al.   NUCLEIC ACIDS RESEARCH

Global role of the bacterial post-transcriptional regulator CsrA revealed by integrated transcriptomics

(2017) Anastasia H. Potts et al.   Nature Communications

Acidic C-terminal domains autoregulate the RNA chaperone Hfq

(2017) Andrew Santiago-Frangos et al.   eLife

Crystal structure and RNA-binding properties of an Hfq homolog from the deep-branching Aquificae: conservation of the lateral RNA-binding mode

(2017) Kimberly A. Stanek et al.   Acta Crystallographica Section D-Structural Biology

Global RNA recognition patterns of post‐transcriptional regulators Hfq and CsrA revealed by UV crosslinkingin vivo

(2016) Erik Holmqvist et al.   EMBO JOURNAL

Characterization of RNA-binding properties of the archaeal Hfq-like protein from Methanococcus jannaschii

(2016) Alexey Nikulin et al.   JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS

Arginine Patch Predicts the RNA Annealing Activity of Hfq from Gram-Negative and Gram-Positive Bacteria

(2016) Amy Zheng et al.   JOURNAL OF MOLECULAR BIOLOGY

Competing endogenous RNAs: a target-centric view of small RNA regulation in bacteria

(2016) Lionello Bossi et al.   NATURE REVIEWS MICROBIOLOGY

C-terminal domain of the RNA chaperone Hfq drives sRNA competition and release of target RNA

(2016) Andrew Santiago-Frangos et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Light-Triggered RNA Annealing by an RNA Chaperone

(2015) Subrata Panja et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Structure of Bacterial Regulatory RNAs Determines Their Performance in Competition for the Chaperone Protein Hfq

(2015) Ewelina M. Małecka et al.   BIOCHEMISTRY

Alternative Hfq-sRNA interaction modes dictate alternative mRNA recognition

(2015) D. J. Schu et al.   EMBO JOURNAL

Acidic Residues in the Hfq Chaperone Increase the Selectivity of sRNA Binding and Annealing

(2015) Subrata Panja et al.   JOURNAL OF MOLECULAR BIOLOGY

Hfq binds directly to the ribosome-binding site of IS10transposase mRNA to inhibit translation

(2015) Michael J. Ellis et al.   MOLECULAR MICROBIOLOGY

sRNATarBase 3.0: an updated database for sRNA-target interactions in bacteria

(2015) Jiang Wang et al.   NUCLEIC ACIDS RESEARCH

Determination of in vivo target search kinetics of regulatory noncoding RNA

(2015) J. Fei et al.   SCIENCE

DISOPRED3: precise disordered region predictions with annotated protein-binding activity

(2014) David T. Jones et al.   BIOINFORMATICS

Quantifying Absolute Protein Synthesis Rates Reveals Principles Underlying Allocation of Cellular Resources

(2014) Gene-Wei Li et al.   CELL

Identification of Bacteriophage-Encoded Anti-sRNAs in Pathogenic Escherichia coli

(2014) Jai J. Tree et al.   MOLECULAR CELL

Curli synthesis and biofilm formation in enteric bacteria are controlled by a dynamic small RNA module made up of a pseudoknot assisted by an RNA chaperone

(2014) Valérie Bordeau et al.   NUCLEIC ACIDS RESEARCH

Structural model of an mRNA in complex with the bacterial chaperone Hfq

(2014) Yi Peng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

RNA binding by Hfq and ring-forming (L)Sm proteins

(2014) Oliver Weichenrieder   RNA Biology

Recognition of U-rich RNA by Hfq from the Gram-positive pathogenListeria monocytogenes

(2014) Alexander R. Kovach et al.   RNA

Evolutionary patterns of Escherichia coli small RNAs and their regulatory interactions

(2014) A. Peer et al.   RNA

Planting the seed: target recognition of short guide RNAs

(2014) Tim Künne et al.   TRENDS IN MICROBIOLOGY

Regulation of Hfq by the RNA CrcZ in Pseudomonas aeruginosa Carbon Catabolite Repression

(2014) Elisabeth Sonnleitner et al.   PLoS Genetics

Structure of anEscherichia coliHfq:RNA complex at 0.97 Å resolution

(2014) Eike C. Schulz et al.   Acta Crystallographica Section F-Structural Biology Communications

A small RNA activates CFA synthase by isoform-specific mRNA stabilization

(2013) Kathrin Sophie Fröhlich et al.   EMBO JOURNAL

Dual function of the McaS small RNA in controlling biofilm formation

(2013) M. G. Jorgensen et al.   GENES & DEVELOPMENT

Bacterial Small RNA-based Negative Regulation: Hfq and Its Accomplices

(2013) Nicholas De Lay et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mutations in Interaction Surfaces Differentially Impact E. coli Hfq Association with Small RNAs and Their mRNA Targets

(2013) Aixia Zhang et al.   JOURNAL OF MOLECULAR BIOLOGY

Protein Expansion Is Primarily due to Indels in Intrinsically Disordered Regions

(2013) S. Light et al.   MOLECULAR BIOLOGY AND EVOLUTION

Crystal structures of the Lsm complex bound to the 3′ end sequence of U6 small nuclear RNA

(2013) Lijun Zhou et al.   NATURE

Mapping Hfq-RNA interaction surfaces using tryptophan fluorescence quenching

(2013) Kirsten E. Robinson et al.   NUCLEIC ACIDS RESEARCH

Conserved arginines on the rim of Hfq catalyze base pair formation and exchange

(2013) Subrata Panja et al.   NUCLEIC ACIDS RESEARCH

The binding mechanisms of intrinsically disordered proteins

(2013) Jakob Dogan et al.   PHYSICAL CHEMISTRY CHEMICAL PHYSICS

Relaxation of backbone bond geometry improves protein energy landscape modeling

(2013) Patrick Conway et al.   PROTEIN SCIENCE

Cycling of RNAs on Hfq

(2013) E. Gerhart H. Wagner   RNA Biology

The bacterial protein Hfq: much more than a mere RNA-binding factor

(2012) Patricio Sobrero et al.   CRITICAL REVIEWS IN MICROBIOLOGY

An atlas of Hfq-bound transcripts reveals 3′ UTRs as a genomic reservoir of regulatory small RNAs

(2012) Yanjie Chao et al.   EMBO JOURNAL

Noncanonical repression of translation initiation through small RNA recruitment of the RNA chaperone Hfq

(2012) G. Desnoyers et al.   GENES & DEVELOPMENT

Mechanisms for Defining Supercoiling Set Point of DNA Gyrase Orthologs

(2012) Elsa M. Tretter et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Characterization of Vibrio cholerae Hfq Provides Novel Insights into the Role of the Hfq C-Terminal Region

(2012) Helen A. Vincent et al.   JOURNAL OF MOLECULAR BIOLOGY

The Seed Region of a Small RNA Drives the Controlled Destruction of the Target mRNA by the Endoribonuclease RNase E

(2012) Katarzyna J. Bandyra et al.   MOLECULAR CELL

Structural mechanism of Staphylococcus aureus Hfq binding to an RNA A-tract

(2012) Nicola Horstmann et al.   NUCLEIC ACIDS RESEARCH

Study of E. coli Hfq’s RNA annealing acceleration and duplex destabilization activities using substrates with different GC-contents

(2012) Martina Doetsch et al.   NUCLEIC ACIDS RESEARCH

Requirement of upstream Hfq-binding (ARN)x elements in glmS and the Hfq C-terminal region for GlmS upregulation by sRNAs GlmZ and GlmY†

(2012) Nilshad N. Salim et al.   NUCLEIC ACIDS RESEARCH

Structural and Biochemical Studies on ATP Binding and Hydrolysis by the Escherichia coli RNA Chaperone Hfq

(2012) Hermann Hämmerle et al.   PLoS One

Small RNA binding to the lateral surface of Hfq hexamers and structural rearrangements upon mRNA target recognition

(2012) E. Sauer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The functional Hfq-binding module of bacterial sRNAs consists of a double or single hairpin preceded by a U-rich sequence and followed by a 3' poly(U) tail

(2012) H. Ishikawa et al.   RNA

Structural analysis of full-length Hfq fromEscherichia coli

(2011) Mads Beich-Frandsen et al.   Acta Crystallographica Section F-Structural Biology and Crystallization Communications

Despite Similar Binding to the Hfq Protein Regulatory RNAs Widely Differ in Their Competition Performance

(2011) Mikołaj Olejniczak   BIOCHEMISTRY

The influence of Escherichia coli Hfq mutations on RNA binding and sRNA•mRNA duplex formation in rpoS riboregulation

(2011) Taylor B. Updegrove et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Structural characterization of the RNA chaperone Hfq from the nitrogen-fixing bacterium Herbaspirillum seropedicae SmR1

(2011) Marco Antonio Seiki Kadowaki et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Cooperation of Escherichia coli Hfq hexamers in DsrA binding

(2011) W. Wang et al.   GENES & DEVELOPMENT

Competition among Hfq-binding small RNAs in Escherichia coli

(2011) Kyung Moon et al.   MOLECULAR MICROBIOLOGY

Hfq and its constellation of RNA

(2011) Jörg Vogel et al.   NATURE REVIEWS MICROBIOLOGY

Dynamic competition of DsrA and rpoS fragments for the proximal binding site of Hfq as a means for efficient annealing

(2011) Wonseok Hwang et al.   NUCLEIC ACIDS RESEARCH

Structural insights into the dynamics and function of the C-terminus of the E. coli RNA chaperone Hfq

(2011) Mads Beich-Frandsen et al.   NUCLEIC ACIDS RESEARCH

Crystal structure of Hfq from Bacillus subtilis in complex with SELEX-derived RNA aptamer: insight into RNA-binding properties of bacterial Hfq

(2011) Tatsuhiko Someya et al.   NUCLEIC ACIDS RESEARCH

Rapid binding and release of Hfq from ternary complexes during RNA annealing

(2011) Julia F. Hopkins et al.   NUCLEIC ACIDS RESEARCH

Quantifying the sequence-function relation in gene silencing by bacterial small RNAs

(2011) Y. Hao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

PolyU tail of rho-independent terminator of bacterial small RNAs is essential for Hfq action

(2011) Hironori Otaka et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural basis for RNA 3′-end recognition by Hfq

(2011) Evelyn Sauer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Major role for mRNA binding and restructuring in sRNA recruitment by Hfq

(2011) T. J. Soper et al.   RNA

Essential Requirements for Robust Signaling in Hfq Dependent Small RNA Networks

(2011) David N. Adamson et al.   PLoS Computational Biology

RNAs actively cycle on the Sm-like protein Hfq

(2010) A. Fender et al.   GENES & DEVELOPMENT

Regulation of Single-stranded DNA Binding by the C Termini of Escherichia coli Single-stranded DNA-binding (SSB) Protein

(2010) Alexander G. Kozlov et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

C-Terminally Truncated Derivatives of Escherichia coli Hfq Are Proficient in Riboregulation

(2010) Anders Steno Olsen et al.   JOURNAL OF MOLECULAR BIOLOGY

Recognition of heptameric seed sequence underlies multi-target regulation by RybB small RNA in Salmonella enterica

(2010) Roberto Balbontín et al.   MOLECULAR MICROBIOLOGY

Identification and function of the RNA chaperone Hfq in the Lyme disease spirochete Borrelia burgdorferi

(2010) Meghan C. Lybecker et al.   MOLECULAR MICROBIOLOGY

Hfq binding at RhlB-recognition region of RNase E is crucial for the rapid degradation of target mRNAs mediated by sRNAs in Escherichia coli

(2010) Yoshiki Ikeda et al.   MOLECULAR MICROBIOLOGY

An Upstream Hfq Binding Site in the fhlA mRNA Leader Region Facilitates the OxyS-fhlA Interaction

(2010) Nilshad N. Salim et al.   PLoS One

Disruption of small RNA signaling caused by competition for Hfq

(2010) R. Hussein et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Evidence for an autonomous 5' target recognition domain in an Hfq-associated small RNA

(2010) K. Papenfort et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Positive regulation by small RNAs and the role of Hfq

(2010) T. Soper et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cyanobacteria contain a structural homologue of the Hfq protein with altered RNA-binding properties

(2009) Andreas Bøggild et al.   FEBS Journal

C-terminal Domain Modulates the Nucleic Acid Chaperone Activity of Human T-cell Leukemia Virus Type 1 Nucleocapsid Protein via an Electrostatic Mechanism

(2009) Dominic F. Qualley et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Comparing Models of Evolution for Ordered and Disordered Proteins

(2009) C. J. Brown et al.   MOLECULAR BIOLOGY AND EVOLUTION

A conserved small RNA promotes silencing of the outer membrane protein YbfM

(2009) Anders Aamann Rasmussen et al.   MOLECULAR MICROBIOLOGY

Coding sequence targeting by MicC RNA reveals bacterial mRNA silencing downstream of translational initiation

(2009) Verena Pfeiffer et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Effect of salt and RNA structure on annealing and strand displacement by Hfq

(2009) J. F. Hopkins et al.   NUCLEIC ACIDS RESEARCH

Structure of Escherichia coli Hfq bound to polyriboadenylate RNA

(2009) T. M. Link et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The rpoS mRNA leader recruits Hfq to facilitate annealing with DsrA sRNA

(2008) T. J. Soper et al.   RNA

Natural selection of protein structural and functional properties: a SNP perspective

(2008) Jinfeng Liu et al.   GENOME BIOLOGY