Strategies to Improve the Clinical Utility of Saporin-Based Targeted Toxins

EV20-Sap, a novel anti-HER-3 antibody-drug conjugate, displays promising antitumor activity in melanoma

(2017) Emily Capone et al.   Oncotarget

Two Saporin-Containing Immunotoxins Specific for CD20 and CD22 Show Different Behavior in Killing Lymphoma Cells

(2017) Letizia Polito et al.   Toxins

Plant Ribosome-Inactivating Proteins: Progesses, Challenges and Biotechnological Applications (and a Few Digressions)

(2017) Maria Fabbrini et al.   Toxins

Methanol-Independent Protein Expression by AOX1 Promoter with trans-Acting Elements Engineering and Glucose-Glycerol-Shift Induction in Pichia pastoris

(2017) Jinjia Wang et al.   Scientific Reports

Construction and characterization of gelonin and saporin plasmids for toxic gene-based cancer therapy

(2016) Kyoung Ah Min et al.   ARCHIVES OF PHARMACAL RESEARCH

Trastuzumab-deBouganin Conjugate Overcomes Multiple Mechanisms of T-DM1 Drug Resistance

(2016) Rachelle L. Dillon et al.   JOURNAL OF IMMUNOTHERAPY

Optimization of construct design and fermentation strategy for the production of bioactive ATF-SAP, a saporin based anti-tumoral uPAR-targeted chimera

(2016) Alfredo Errico Provenzano et al.   Microbial Cell Factories

High in Vitro Anti-Tumor Efficacy of Dimeric Rituximab/Saporin-S6 Immunotoxin

(2016) Massimo Bortolotti et al.   Toxins

Soapwort Saporin L3 Expression in Yeast, Mutagenesis, and RNA Substrate Specificity

(2015) Hongling Yuan et al.   BIOCHEMISTRY

PDZ Domain in the Engineering and Production of a Saporin Chimeric Toxin as a Tool for targeting Cancer Cells

(2015) Francesco Giansanti et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Light-controlled endosomal escape of the novel CD133-targeting immunotoxin AC133–saporin by photochemical internalization — A minimally invasive cancer stem cell-targeting strategy

(2015) Monica Bostad et al.   JOURNAL OF CONTROLLED RELEASE

Combined treatment with a pH-sensitive fusogenic peptide and cationic lipids achieves enhanced cytosolic delivery of exosomes

(2015) Ikuhiko Nakase et al.   Scientific Reports

Triterpenoid saponin augmention of saporin-based immunotoxin cytotoxicity for human leukaemia and lymphoma cells is partially immunospecific and target molecule dependent

(2014) Suzanne E. Holmes et al.   IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY

The novel EpCAM-targeting monoclonal antibody 3–17I linked to saporin is highly cytotoxic after photochemical internalization in breast, pancreas and colon cancer cell lines

(2014) Kaja Lund et al.   mAbs

High-content Analysis of Antibody Phage-display Library Selection Outputs Identifies Tumor Selective Macropinocytosis-dependent Rapidly Internalizing Antibodies

(2014) Kevin D. Ha et al.   MOLECULAR & CELLULAR PROTEOMICS

Light-Triggered, Efficient Cytosolic Release of IM7-Saporin Targeting the Putative Cancer Stem Cell Marker CD44 by Photochemical Internalization

(2014) Monica Bostad et al.   MOLECULAR PHARMACEUTICS

Vascular endothelial cells as targets for photochemical internalization (PCI)

(2013) Marie Vikdal et al.   PHOTOCHEMISTRY AND PHOTOBIOLOGY

Disruption of the Putative Vascular Leak Peptide Sequence in the Stabilized Ricin Vaccine Candidate RTA1-33/44-198

(2013) Laszlo Janosi et al.   Toxins

Saporin-S6: A Useful Tool in Cancer Therapy

(2013) Letizia Polito et al.   Toxins

Photochemical internalization (PCI) of HER2-targeted toxins

(2012) Maria Brandal Berstad et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Targeted tumor therapy by epidermal growth factor appended toxin and purified saponin: An evaluation of toxicity and therapeutic potential in syngeneic tumor bearing mice

(2012) Mayank Thakur et al.   Molecular Oncology

Functional classification of class II human leukocyte antigen (HLA) molecules reveals seven different supertypes and a surprising degree of repertoire sharing across supertypes

(2011) Jason Greenbaum et al.   IMMUNOGENETICS

Retrograde Transport: Two (or More) Roads Diverged in an Endosomal Tree?

(2011) Ludger Johannes et al.   TRAFFIC

Ricin Trafficking in Plant and Mammalian Cells

(2011) J. Michael Lord et al.   Toxins

Peptide binding predictions for HLA DR, DP and DQ molecules

(2010) Peng Wang et al.   BMC BIOINFORMATICS

A comparison of anti-lymphocyte immunotoxins containing different ribosome-inactivating proteins and antibodies

(2010) A. BOLOGNESI et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

A new bioinformatics analysis tools framework at EMBL-EBI

(2010) M. Goujon et al.   NUCLEIC ACIDS RESEARCH

Signal peptide-regulated toxicity of a plant ribosome-inactivating protein during cell stress

(2010) Richard S. Marshall et al.   PLANT JOURNAL

Structure of recombinant ricin A chain at 2.3 Å

(2010) Debra Mlsna et al.   PROTEIN SCIENCE

Ribosome-Inactivating Proteins: From Plant Defense to Tumor Attack

(2010) Maddalena de Virgilio et al.   Toxins

Crystal structure of PD-L1, a ribosome inactivating protein fromPhytolacca dioicaL. Leaves with the property to induce DNA cleavage

(2009) Alessia Ruggiero et al.   BIOPOLYMERS

A BRIEF COMMUNICATION

(2009) Alexander Weng et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Pichia pastoris as a host for secretion of toxic saporin chimeras

(2009) Alessio Lombardi et al.   FASEB JOURNAL

Engineering and Biological Characterization of VB6-845, an Anti-EpCAM Immunotoxin Containing a T-cell Epitope-depleted Variant of the Plant Toxin Bouganin

(2009) Jeannick Cizeau et al.   JOURNAL OF IMMUNOTHERAPY

Inhibition of Tumor Growth by Targeted Toxins in Mice is Dramatically Improved by Saponinum Album in a Synergistic Way

(2009) Christopher Bachran et al.   JOURNAL OF IMMUNOTHERAPY

Engineering a switchable toxin: the potential use of PDZ domains in the expression, targeting and activation of modified saporin variants

(2009) F. Giansanti et al.   PROTEIN ENGINEERING DESIGN & SELECTION

Ribosome inactivating protein saporin induces apoptosis through mitochondrial cascade, independent of translation inhibition

(2008) Deepa Sikriwal et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Enhancement of Saporin Toxicity Against U937 Cells by Gypsophila Saponins

(2008) A. Weng et al.   Journal of Immunotoxicology

Crystal structure of native cinnamomin isoform III and its comparison with other ribosome inactivating proteins

(2008) Arezki Azzi et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Enhanced cytotoxicity of saporin by polyamidoamine dendrimer conjugation and photochemical internalization

(2007) Ping-Shan Lai et al.   JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A