Plant Ribosome-Inactivating Proteins: Progesses, Challenges and Biotechnological Applications (and a Few Digressions)

Cytosolic antibody delivery by lipid-sensitive endosomolytic peptide

(2017) Misao Akishiba et al.   Nature Chemistry

Arginine-rich cell-penetrating peptide-modified extracellular vesicles for active macropinocytosis induction and efficient intracellular delivery

(2017) Ikuhiko Nakase et al.   Scientific Reports

Two Saporin-Containing Immunotoxins Specific for CD20 and CD22 Show Different Behavior in Killing Lymphoma Cells

(2017) Letizia Polito et al.   Toxins

Fate and action of ricin in rat liverin vivo: translocation of endocytosed ricin into cytosol and induction of intrinsic apoptosis by ricin B-chain

(2016) François Authier et al.   CELLULAR MICROBIOLOGY

Progress and challenges associated with the development of ricin toxin subunit vaccines

(2016) David J. Vance et al.   Expert Review of Vaccines

Cell-penetrating peptides as noninvasive transmembrane vectors for the development of novel multifunctional drug-delivery systems

(2016) Dongdong Zhang et al.   JOURNAL OF CONTROLLED RELEASE

Optimization of construct design and fermentation strategy for the production of bioactive ATF-SAP, a saporin based anti-tumoral uPAR-targeted chimera

(2016) Alfredo Errico Provenzano et al.   Microbial Cell Factories

Dual-Targeting Nanoparticles for In Vivo Delivery of Suicide Genes to Chemotherapy-Resistant Ovarian Cancer Cells

(2016) Emiliano Cocco et al.   MOLECULAR CANCER THERAPEUTICS

Cathepsin B-degradable, NIR-responsive nanoparticulate platform for target-specific cancer therapy

(2016) Sam P Tarassoli et al.   NANOTECHNOLOGY

Nanoparticle-mediated delivery of suicide genes in cancer therapy

(2016) Riccardo Vago et al.   PHARMACOLOGICAL RESEARCH

Modulation of tissue tropism and biological activity of exosomes and other extracellular vesicles: New nanotools for cancer treatment

(2016) Sander A.A. Kooijmans et al.   PHARMACOLOGICAL RESEARCH

An Electrochemiluminescence Immunosensor Based on Gold-Magnetic Nanoparticles and Phage Displayed Antibodies

(2016) Xihui Mu et al.   SENSORS

Augmenting the Efficacy of Immunotoxins and Other Targeted Protein Toxins by Endosomal Escape Enhancers

(2016) Hendrik Fuchs et al.   Toxins

A Bispecific Antibody Promotes Aggregation of Ricin Toxin on Cell Surfaces and Alters Dynamics of Toxin Internalization and Trafficking

(2016) Cristina Herrera et al.   PLoS One

Specific Elimination of Latently HIV-1 Infected Cells Using HIV-1 Protease-Sensitive Toxin Nanocapsules

(2016) Jing Wen et al.   PLoS One

Vectorization of biomacromolecules into cells using extracellular vesicles with enhanced internalization induced by macropinocytosis

(2016) Ikuhiko Nakase et al.   Scientific Reports

Depletion of Alloreactive T-Cells by Anti-CD137-Saporin Immunotoxin

(2015) Sang C. Lee et al.   CELL TRANSPLANTATION

Light-controlled endosomal escape of the novel CD133-targeting immunotoxin AC133–saporin by photochemical internalization — A minimally invasive cancer stem cell-targeting strategy

(2015) Monica Bostad et al.   JOURNAL OF CONTROLLED RELEASE

Structural analysis of a type 1 ribosome inactivating protein reveals multiple L-asparagine-N-acetyl-D-glucosamine monosaccharide modifications: Implications for cytotoxicity

(2015) TANIS HOGG et al.   Molecular Medicine Reports

Design of an EGFR-targeting toxin for photochemical delivery: in vitro and in vivo selectivity and efficacy

(2015) M B Berstad et al.   ONCOGENE

Thermostable ricin vaccine protects rhesus macaques against aerosolized ricin: Epitope-specific neutralizing antibodies correlate with protection

(2015) Chad J. Roy et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Safety and immunogenicity of ricin vaccine, RV Ec ™, in a Phase 1 clinical trial

(2015) Phillip R. Pittman et al.   VACCINE

Combined treatment with a pH-sensitive fusogenic peptide and cationic lipids achieves enhanced cytosolic delivery of exosomes

(2015) Ikuhiko Nakase et al.   Scientific Reports

Two complementary approaches for intracellular delivery of exogenous enzymes

(2015) Aleksander Rust et al.   Scientific Reports

Active macropinocytosis induction by stimulation of epidermal growth factor receptor and oncogenic Ras expression potentiates cellular uptake efficacy of exosomes

(2015) Ikuhiko Nakase et al.   Scientific Reports

Ebulin from Dwarf Elder (Sambucus ebulus L.): A Mini-Review

(2015) Pilar Jiménez et al.   Toxins

Ribosome-Inactivating and Related Proteins

(2015) Joachim Schrot et al.   Toxins

Pokeweed Antiviral Protein: Its Cytotoxicity Mechanism and Applications in Plant Disease Resistance

(2015) Rong Di et al.   Toxins

A Small-Molecule Drug Conjugate for the Treatment of Carbonic Anhydrase IX Expressing Tumors

(2014) Nikolaus Krall et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Combinatorially Designed Lipid-like Nanoparticles for Intracellular Delivery of Cytotoxic Protein for Cancer Therapy

(2014) Ming Wang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Molecular interplays involved in the cellular uptake of octaarginine on cell surfaces and the importance of syndecan-4 cytoplasmic V domain for the activation of protein kinase Cα

(2014) Ikuhiko Nakase et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Immunotoxins Constructed with Ribosome-Inactivating Proteins and their Enhancers: A Lethal Cocktail with Tumor Specific Efficacy

(2014) Roger Gilabert-Oriol et al.   CURRENT PHARMACEUTICAL DESIGN

Dianthin-EGF is an effective tumor targeted toxin in combination with saponins in a xenograft model for colon carcinoma

(2014) Benedicta von Mallinckrodt et al.   Future Oncology

Depletion of inflammatory dendritic cells with anti-CD209 conjugated to saporin toxin

(2014) Michael N. Alonso et al.   IMMUNOLOGIC RESEARCH

Photochemical internalization augments tumor vascular cytotoxicity and specificity of VEGF121/rGel fusion toxin

(2014) Anette Weyergang et al.   JOURNAL OF CONTROLLED RELEASE

Cholinergic immunotoxin 192 IgG-SAPORIN alters subicular theta–gamma activity and impairs spatial learning in rats

(2014) Shweta Rastogi et al.   NEUROBIOLOGY OF LEARNING AND MEMORY

Intrathecal Substance P-Saporin in the Dog

(2013) Dorothy Cimino Brown et al.   ANESTHESIOLOGY

Intrathecal Substance P-Saporin in the Dog

(2013) Ashley J. Wiese et al.   ANESTHESIOLOGY

The role of EDEM2 compared with EDEM1 in ricin transport from the endoplasmic reticulum to the cytosol

(2013) Monika Słomińska-Wojewódzka et al.   BIOCHEMICAL JOURNAL

Synergistic Antitumor Activity from Two-Stage Delivery of Targeted Toxins and Endosome-Disrupting Nanoparticles

(2013) Xingfang Su et al.   BIOMACROMOLECULES

A Systematic Mammalian Genetic Interaction Map Reveals Pathways Underlying Ricin Susceptibility

(2013) Michael C. Bassik et al.   CELL

Visualization and in vivo tracking of the exosomes of murine melanoma B16-BL6 cells in mice after intravenous injection

(2013) Yuki Takahashi et al.   JOURNAL OF BIOTECHNOLOGY

Chemically and biologically synthesized CPP-modified gelonin for enhanced anti-tumor activity

(2013) Meong Cheol Shin et al.   JOURNAL OF CONTROLLED RELEASE

DNA Based Therapy with Diphtheria Toxin-A BC-819: A Phase 2b Marker Lesion Trial in Patients with Intermediate Risk Nonmuscle Invasive Bladder Cancer

(2013) Ofer N. Gofrit et al.   JOURNAL OF UROLOGY

Design optimization and characterization of Her2/neu-targeted immunotoxins: comparative in vitro and in vivo efficacy studies

(2013) Y Cao et al.   ONCOGENE

Ribosome-inactivating proteins: From toxins to useful proteins

(2013) Fiorenzo Stirpe   TOXICON

Saporin-S6: A Useful Tool in Cancer Therapy

(2013) Letizia Polito et al.   Toxins

Exosomes as nano-theranostic delivery platforms for gene therapy

(2012) Aaron Tan et al.   ADVANCED DRUG DELIVERY REVIEWS

Exosomes: Current knowledge of their composition, biological functions, and diagnostic and therapeutic potentials

(2012) Alexander V. Vlassov et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

CXCR4 Stimulates Macropinocytosis: Implications for Cellular Uptake of Arginine-Rich Cell-Penetrating Peptides and HIV

(2012) Gen Tanaka et al.   CHEMISTRY & BIOLOGY

Pilot Phase IB Clinical Trial of an Alhydrogel-Adsorbed Recombinant Ricin Vaccine

(2012) Ellen S. Vitetta et al.   Clinical and Vaccine Immunology

Accumulation of arginine-rich cell-penetrating peptides in tumors and the potential for anticancer drug delivery in vivo

(2012) Ikuhiko Nakase et al.   JOURNAL OF CONTROLLED RELEASE

Cell-penetrating peptides (CPPs) as a vector for the delivery of siRNAs into cells

(2012) Ikuhiko Nakase et al.   Molecular BioSystems

Targeted tumor therapy by epidermal growth factor appended toxin and purified saponin: An evaluation of toxicity and therapeutic potential in syngeneic tumor bearing mice

(2012) Mayank Thakur et al.   Molecular Oncology

Eukaryotic expression vectors bearing genes encoding cytotoxic proteins for cancer gene therapy

(2012) Elena M. Glinka   PLASMID

A single point mutation in ricin A-chain increases toxin degradation and inhibits EDEM1-dependent ER retrotranslocation

(2011) Iwona Sokołowska et al.   BIOCHEMICAL JOURNAL

Exosomes Released by Melanoma Cells Prepare Sentinel Lymph Nodes for Tumor Metastasis

(2011) J. L. Hood et al.   CANCER RESEARCH

Characterisation of exosomes derived from human cells by nanoparticle tracking analysis and scanning electron microscopy

(2011) Viktoriya Sokolova et al.   COLLOIDS AND SURFACES B-BIOINTERFACES

Sensitive Angiogenesis Imaging of Orthotopic Bladder Tumors in Mice Using a Selective Magnetic Resonance Imaging Contrast Agent Containing VEGF121/rGel

(2011) Eun-Jin Cho et al.   INVESTIGATIVE RADIOLOGY

Microvesicles and exosomes: Opportunities for cell-derived membrane vesicles in drug delivery

(2011) Susan M. van Dommelen et al.   JOURNAL OF CONTROLLED RELEASE

Engineered Toxins “Zymoxins” Are Activated by the HCV NS3 Protease by Removal of an Inhibitory Protein Domain

(2011) Assaf Shapira et al.   PLoS One

Protective Effect of Two Recombinant Ricin Subunit Vaccines in the New Zealand White Rabbit Subjected to a Lethal Aerosolized Ricin Challenge: Survival, Immunological Response, and Histopathological Findings

(2011) Daniel E. McLain et al.   TOXICOLOGICAL SCIENCES

Ricin Trafficking in Plant and Mammalian Cells

(2011) J. Michael Lord et al.   Toxins

Photochemical internalization provides time- and space-controlled endolysosomal escape of therapeutic molecules

(2010) Pål Kristian Selbo et al.   JOURNAL OF CONTROLLED RELEASE

Endosomal escape pathways for delivery of biologicals

(2010) Amir K. Varkouhi et al.   JOURNAL OF CONTROLLED RELEASE

Exosomes account for vesicle-mediated transcellular transport of activatable phospholipases and prostaglandins

(2010) Caroline Subra et al.   JOURNAL OF LIPID RESEARCH

Bioengineering a Unique Deimmunized Bispecific Targeted Toxin That Simultaneously Recognizes Human CD22 and CD19 Receptors in a Mouse Model of B-Cell Metastases

(2010) D. A. Vallera et al.   MOLECULAR CANCER THERAPEUTICS

Homodimerization of pokeweed antiviral protein as a mechanism to limit depurination of pokeweed ribosomes

(2010) MARINA E. TOURLAKIS et al.   MOLECULAR PLANT PATHOLOGY

Signal peptide-regulated toxicity of a plant ribosome-inactivating protein during cell stress

(2010) Richard S. Marshall et al.   PLANT JOURNAL

Intradermal administration of RiVax protects mice from mucosal and systemic ricin intoxication

(2010) Praveena S. Marconescu et al.   VACCINE

Ribosome-Inactivating Proteins: From Plant Defense to Tumor Attack

(2010) Maddalena de Virgilio et al.   Toxins

Transition State Analogues Rescue Ribosomes from Saporin-L1 Ribosome Inactivating Protein

(2009) Matthew B. Sturm et al.   BIOCHEMISTRY

Cytosolic Targeting of Macromolecules Using a pH-Dependent Fusogenic Peptide in Combination with Cationic Liposomes

(2009) Sachiko Kobayashi et al.   BIOCONJUGATE CHEMISTRY

Targeted Elimination of Leukemia Stem Cells; a New Therapeutic Approach in Hemato-Oncology

(2009) B. Cate et al.   CURRENT DRUG TARGETS

Ricin poisoning and forensic toxicology

(2009) Frank Musshoff et al.   Drug Testing and Analysis

Pichia pastoris as a host for secretion of toxic saporin chimeras

(2009) Alessio Lombardi et al.   FASEB JOURNAL

Ricin A Chain Insertion into Endoplasmic Reticulum Membranes Is Triggered by a Temperature Increase to 37 °C

(2009) Peter U. Mayerhofer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inhibition of Tumor Growth by Targeted Toxins in Mice is Dramatically Improved by Saponinum Album in a Synergistic Way

(2009) Christopher Bachran et al.   JOURNAL OF IMMUNOTHERAPY

Intracellulartransduction using cell-penetrating peptides

(2009) Rupa Sawant et al.   Molecular BioSystems

A Novel Strategy for the Invasive Toxin: Hijacking Exosome-Mediated Intercellular Trafficking

(2009) Fan Zhang et al.   TRAFFIC

Ribosome inactivating protein saporin induces apoptosis through mitochondrial cascade, independent of translation inhibition

(2008) Deepa Sikriwal et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

The Role of CDC48 in the Retro-translocation of Non-ubiquitinated Toxin Substrates in Plant Cells

(2008) Richard S. Marshall et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Characterization and Comprehensive Proteome Profiling of Exosomes Secreted by Hepatocytes

(2008) Javier Conde-Vancells et al.   JOURNAL OF PROTEOME RESEARCH

LDL Receptor-Related Protein 1: Unique Tissue-Specific Functions Revealed by Selective Gene Knockout Studies

(2008) Anna P. Lillis et al.   PHYSIOLOGICAL REVIEWS

Cytosolic chaperones influence the fate of a toxin dislocated from the endoplasmic reticulum

(2008) R. A. Spooner et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Endoplasmic Reticulum Quality Control and the Unfolded Protein Response: Insights from Plants

(2008) Alessandro Vitale et al.   TRAFFIC

Epidermal growth factor stimulates Rac activation through Src and phosphatidylinositol 3-kinase to promote colonic epithelial cell migration

(2007) Rebecca S. Dise et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Enhanced cytotoxicity of saporin by polyamidoamine dendrimer conjugation and photochemical internalization

(2007) Ping-Shan Lai et al.   JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A