A lipid-binding loop of botulinum neurotoxin serotypes B, DC and G is an essential feature to confer their exquisite potency

Identification of a Botulinum Neurotoxin-like Toxin in a Commensal Strain of Enterococcus faecium

(2018) Sicai Zhang et al.   Cell Host & Microbe

Identification of a novel botulinum neurotoxin gene cluster in Enterococcus

(2018) Jason Brunt et al.   FEBS LETTERS

Structural basis for the unique ganglioside and cell membrane recognition mechanism of botulinum neurotoxin DC

(2017) Sicai Zhang et al.   Nature Communications

Identification and characterization of a novel botulinum neurotoxin

(2017) Sicai Zhang et al.   Nature Communications

Affinity biosensors using recombinant native membrane proteins displayed on exosomes: application to botulinum neurotoxin B receptor

(2017) Richard Desplantes et al.   Scientific Reports

A camelid single-domain antibody neutralizes botulinum neurotoxin A by blocking host receptor binding

(2017) Guorui Yao et al.   Scientific Reports

Only the complex N559-glycan in the synaptic vesicle glycoprotein 2C mediates high affinity binding to botulinum neurotoxin serotype A1

(2016) S. Mahrhold et al.   BIOCHEMICAL JOURNAL

Structure and lipid-binding properties of the kindlin-3 pleckstrin homology domain

(2016) Tao Ni et al.   BIOCHEMICAL JOURNAL

Glycans Confer Specificity to the Recognition of Ganglioside Receptors by Botulinum Neurotoxin A

(2016) Christoffer Hamark et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

N-linked glycosylation of SV2 is required for binding and uptake of botulinum neurotoxin A

(2016) Guorui Yao et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

N-linked glycosylation of SV2 is required for binding and uptake of botulinum neurotoxin A

(2016) Guorui Yao et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Botulinum Neurotoxin Serotype A Recognizes Its Protein Receptor SV2 by a Different Mechanism than Botulinum Neurotoxin B Synaptotagmin

(2016) Jasmin Weisemann et al.   Toxins

Structural and Thermodynamic Basis of Epitope Binding by Neutralizing and Nonneutralizing Forms of the Anti-HIV-1 Antibody 4E10

(2015) Edurne Rujas et al.   JOURNAL OF VIROLOGY

The long journey of botulinum neurotoxins into the synapse

(2015) Andreas Rummel   TOXICON

Botulinum Neurotoxins: Qualitative and Quantitative Analysis Using the Mouse Phrenic Nerve Hemidiaphragm Assay (MPN)

(2015) Hans Bigalke et al.   Toxins

Identification of the synaptic vesicle glycoprotein 2 receptor binding site in botulinum neurotoxin A

(2014) Jasmin Strotmeier et al.   FEBS LETTERS

Botulinum neurotoxins: genetic, structural and mechanistic insights

(2014) Ornella Rossetto et al.   NATURE REVIEWS MICROBIOLOGY

Identification of the SV2 protein receptor-binding site of botulinum neurotoxin type E

(2013) Stefan Mahrhold et al.   BIOCHEMICAL JOURNAL

Botulinum Neurotoxin G Binds Synaptotagmin-II in a Mode Similar to That of Serotype B: Tyrosine 1186 and Lysine 1191 Cause Its Lower Affinity

(2013) Gesche Willjes et al.   BIOCHEMISTRY

Structural basis for recognition of synaptic vesicle protein 2C by botulinum neurotoxin A

(2013) Roger M. Benoit et al.   NATURE

Crystal Structures of Botulinum Neurotoxin DC in Complex with Its Protein Receptors Synaptotagmin I and II

(2013) Ronnie Per-Arne Berntsson et al.   STRUCTURE

Structure of dual receptor binding to botulinum neurotoxin B

(2013) Ronnie P-A. Berntsson et al.   Nature Communications

Structure of a Bimodular Botulinum Neurotoxin Complex Provides Insights into Its Oral Toxicity

(2013) Kwangkook Lee et al.   PLoS Pathogens

Botulinum Neurotoxin Serotype C Associates with Dual Ganglioside Receptors to Facilitate Cell Entry

(2012) Andrew P.-A. Karalewitz et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Botulinum neurotoxin D-C uses synaptotagmin I and II as receptors, and human synaptotagmin II is not an effective receptor for type B, D-C and G toxins

(2012) Lisheng Peng et al.   JOURNAL OF CELL SCIENCE

Structural and mutational analyses of the receptor binding domain of botulinum D/C mosaic neurotoxin: Insight into the ganglioside binding mechanism

(2011) Nipawan Nuemket et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Receptor Binding Enables Botulinum Neurotoxin B to Sense Low pH for Translocation Channel Assembly

(2011) Shihu Sun et al.   Cell Host & Microbe

Unique ganglioside binding by botulinum neurotoxins C and D-SA

(2011) Abby R. Kroken et al.   FEBS Journal

Unique Ganglioside Recognition Strategies for Clostridial Neurotoxins

(2011) Marc A. Benson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Novel Ganglioside-mediated Entry of Botulinum Neurotoxin Serotype D into Neurons

(2011) Abby R. Kroken et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The biological activity of botulinum neurotoxin type C is dependent upon novel types of ganglioside binding sites

(2011) Jasmin Strotmeier et al.   MOLECULAR MICROBIOLOGY

Botulinum Neurotoxin D Uses Synaptic Vesicle Protein SV2 and Gangliosides as Receptors

(2011) Lisheng Peng et al.   PLoS Pathogens

Pentaplexed Quantitative Real-Time PCR Assay for the Simultaneous Detection and Quantification of Botulinum Neurotoxin-Producing Clostridia in Food and Clinical Samples

(2010) S. Kirchner et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Botulinum neurotoxin serotype D attacks neurons via two carbohydrate-binding sites in a ganglioside-dependent manner

(2010) Jasmin Strotmeier et al.   BIOCHEMICAL JOURNAL

Identification of a Unique Ganglioside Binding Loop within Botulinum Neurotoxins C and D-SA,

(2010) Andrew P.-A. Karalewitz et al.   BIOCHEMISTRY

Crystal Structure of the Botulinum Neurotoxin Type G Binding Domain: Insight into Cell Surface Binding

(2010) Pål Stenmark et al.   JOURNAL OF MOLECULAR BIOLOGY

Aromatic residues at the edge of the antibody combining site facilitate viral glycoprotein recognition through membrane interactions

(2010) E. M. Scherer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The N-terminal half of the receptor domain of botulinum neurotoxin A binds to microdomains of the plasma membrane

(2009) Lucia Muraro et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Glycosylated SV2 and Gangliosides as Dual Receptors for Botulinum Neurotoxin Serotype F

(2009) Zhuji Fu et al.   BIOCHEMISTRY

Electric dipole reorientation in the interaction of botulinum neurotoxins with neuronal membranes

(2009) Federico Fogolari et al.   FEBS LETTERS

Botulinum neurotoxins C, E and F bind gangliosides via a conserved binding site prior to stimulation-dependent uptake with botulinum neurotoxin F utilising the three isoforms of SV2 as second receptor

(2009) Andreas Rummel et al.   JOURNAL OF NEUROCHEMISTRY

Domain Organization in Clostridium botulinum Neurotoxin Type E Is Unique: Its Implication in Faster Translocation

(2008) Desigan Kumaran et al.   JOURNAL OF MOLECULAR BIOLOGY

Identification of the receptor-binding sites in the carboxyl-terminal half of the heavy chain of botulinum neurotoxin types C and D

(2008) Kentaro Tsukamoto et al.   MICROBIAL PATHOGENESIS

Glycosylated SV2A and SV2B Mediate the Entry of Botulinum Neurotoxin E into Neurons

(2008) Min Dong et al.   MOLECULAR BIOLOGY OF THE CELL

Membrane recognition by phospholipid-binding domains

(2008) Mark A. Lemmon   NATURE REVIEWS MOLECULAR CELL BIOLOGY