IL-1α and Complement Cooperate in Triggering Local Neutrophilic Inflammation in Response to Adenovirus and Eliminating Virus-Containing Cells

A Novel Targeted Inhibitor of the Alternative Pathway of Complement and Its Therapeutic Application in Ischemia/Reperfusion Injury

(2014) Y. Huang et al.   JOURNAL OF IMMUNOLOGY

Interleukin-1 Receptor 2 Keeps the Lid on Interleukin-1α

(2013) Nelson C. Di Paolo et al.   IMMUNITY

Intracellular Interleukin-1 Receptor 2 Binding Prevents Cleavage and Activity of Interleukin-1α, Controlling Necrosis-Induced Sterile Inflammation

(2013) Yue Zheng et al.   IMMUNITY

The Transcription Factor IRF3 Triggers “Defensive Suicide” Necrosis in Response to Viral and Bacterial Pathogens

(2013) Nelson C. Di Paolo et al.   Cell Reports

Neutrophil Cerebrovascular Transmigration Triggers Rapid Neurotoxicity through Release of Proteases Associated with Decondensed DNA

(2012) C. Allen et al.   JOURNAL OF IMMUNOLOGY

Kupffer cells express a unique combination of phenotypic and functional characteristics compared with splenic and peritoneal macrophages

(2012) Dowty Movita et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Ad5:Ad48 Hexon Hypervariable Region Substitutions Lead to Toxicity and Increased Inflammatory Responses Following Intravenous Delivery

(2012) Lynda Coughlan et al.   MOLECULAR THERAPY

Gene-expression profiles and transcriptional regulatory pathways that underlie the identity and diversity of mouse tissue macrophages

(2012) Emmanuel L Gautier et al.   NATURE IMMUNOLOGY

Treating inflammation by blocking interleukin-1 in a broad spectrum of diseases

(2012) Charles A. Dinarello et al.   NATURE REVIEWS DRUG DISCOVERY

Coagulation Factor X Activates Innate Immunity to Human Species C Adenovirus

(2012) K. Doronin et al.   SCIENCE

Interleukin-1 in the pathogenesis and treatment of inflammatory diseases

(2011) C. A. Dinarello   BLOOD

The CXCR4 antagonist plerixafor is a potential therapy for myelokathexis, WHIM syndrome

(2011) D. C. Dale et al.   BLOOD

Molecular definitions of cell death subroutines: recommendations of the Nomenclature Committee on Cell Death 2012

(2011) L Galluzzi et al.   CELL DEATH AND DIFFERENTIATION

Advances and Future Challenges in Adenoviral Vector Pharmacology and Targeting

(2011) Reeti Khare et al.   CURRENT GENE THERAPY

Cellular and molecular choreography of neutrophil recruitment to sites of sterile inflammation

(2011) Braedon McDonald et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Real-Time Dynamic Imaging of Virus Distribution In Vivo

(2011) Sean E. Hofherr et al.   PLoS One

Adenovirus

(2011) Joseph Lynch et al.   SEMINARS IN RESPIRATORY AND CRITICAL CARE MEDICINE

Biodistribution and retargeting of FX-binding ablated adenovirus serotype 5 vectors

(2010) R. Alba et al.   BLOOD

Targeted Complement Inhibitors Protect against Posttransplant Cardiac Ischemia and Reperfusion Injury and Reveal an Important Role for the Alternative Pathway of Complement Activation

(2010) C. Atkinson et al.   JOURNAL OF IMMUNOLOGY

Development of a Targeted Gene Vector Platform Based on Simian Adenovirus Serotype 24

(2010) N. Belousova et al.   JOURNAL OF VIROLOGY

Immunological and Inflammatory Functions of the Interleukin-1 Family

(2009) Charles A. Dinarello   Annual Review of Immunology

Insights into the biology of mobilized hematopoietic stem/progenitor cells through innovative treatment schedules of the CXCR4 antagonist AMD3100

(2009) Halvard Bonig et al.   EXPERIMENTAL HEMATOLOGY

Virus Binding to a Plasma Membrane Receptor Triggers Interleukin-1α-Mediated Proinflammatory Macrophage Response In Vivo

(2009) Nelson C. Di Paolo et al.   IMMUNITY

When two is better than one: macrophages and neutrophils work in concert in innate immunity as complementary and cooperative partners of a myeloid phagocyte system

(2009) Manuel T. Silva   JOURNAL OF LEUKOCYTE BIOLOGY

Adenovirus Activates Complement by Distinctly Different Mechanisms In Vitro and In Vivo: Indirect Complement Activation by Virions In Vivo

(2009) J. Tian et al.   JOURNAL OF VIROLOGY

Induction of Shock After Intravenous Injection of Adenovirus Vectors: A Critical Role for Platelet-activating Factor

(2009) Zhili Xu et al.   MOLECULAR THERAPY

Current Issues and Future Directions of Oncolytic Adenoviruses

(2009) Masato Yamamoto et al.   MOLECULAR THERAPY

Comparative analysis of vector biodistribution, persistence and gene expression following intravenous delivery of bovine, porcine and human adenoviral vectors in a mouse model

(2009) Anurag Sharma et al.   VIROLOGY

Interaction of Systemically Delivered Adenovirus Vectors with Kupffer Cells in Mouse Liver

(2008) Jeffrey S. Smith et al.   HUMAN GENE THERAPY