Fab-based inhibitors reveal ubiquitin independent functions for HIV Vif neutralization of APOBEC3 restriction factors

Synthesis, biological evaluation and molecular docking study of N -(2-methoxyphenyl)-6-((4-nitrophenyl)sulfonyl)benzamide derivatives as potent HIV-1 Vif antagonists

(2017) Meng Zhou et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

cryoSPARC: algorithms for rapid unsupervised cryo-EM structure determination

(2017) Ali Punjani et al.   NATURE METHODS

Identification of an HIV-1 replication inhibitor which rescues host restriction factor APOBEC3G in Vif–APOBEC3G complex

(2015) Shaoyang Zhang et al.   ANTIVIRAL RESEARCH

CTFFIND4: Fast and accurate defocus estimation from electron micrographs

(2015) Alexis Rohou et al.   JOURNAL OF STRUCTURAL BIOLOGY

The Phyre2 web portal for protein modeling, prediction and analysis

(2015) Lawrence A Kelley et al.   Nature Protocols

Insights into Cullin-RING E3 Ubiquitin Ligase Recruitment: Structure of the VHL-EloBC-Cul2 Complex

(2015) Henry C. Nguyen et al.   STRUCTURE

Transcriptional regulation of APOBEC3 antiviral immunity through the CBF- /RUNX axis

(2015) B. D. Anderson et al.   Science Advances

Structural basis for hijacking CBF-β and CUL5 E3 ligase complex by HIV-1 Vif

(2014) Yingying Guo et al.   NATURE

Structural insights for HIV-1 therapeutic strategies targeting Vif

(2014) Jason D. Salter et al.   TRENDS IN BIOCHEMICAL SCIENCES

CBFβ Stabilizes HIV Vif to Counteract APOBEC3 at the Expense of RUNX1 Target Gene Expression

(2013) Dong Young Kim et al.   MOLECULAR CELL

Inhibition of a NEDD8 Cascade Restores Restriction of HIV by APOBEC3G

(2013) David J. Stanley et al.   PLoS Pathogens

RELION: Implementation of a Bayesian approach to cryo-EM structure determination

(2012) Sjors H.W. Scheres   JOURNAL OF STRUCTURAL BIOLOGY

The APOBEC3C crystal structure and the interface for HIV-1 Vif binding

(2012) Shingo Kitamura et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Rapid identification of recombinant Fabs that bind to membrane proteins

(2011) JungMin Kim et al.   METHODS

T-cell differentiation factor CBF-β regulates HIV-1 Vif-mediated evasion of host restriction

(2011) Wenyan Zhang et al.   NATURE

Vif hijacks CBF-β to degrade APOBEC3G and promote HIV-1 infection

(2011) Stefanie Jäger et al.   NATURE

Multiple ways of targeting APOBEC3–virion infectivity factor interactions for anti-HIV-1 drug development

(2009) Jessica L. Smith et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Novel targets for HIV therapy

(2008) W GREENE et al.   ANTIVIRAL RESEARCH

Multimodal Activation of the Ubiquitin Ligase SCF by Nedd8 Conjugation

(2008) Anjanabha Saha et al.   MOLECULAR CELL

Small-molecule inhibition of HIV-1 Vif

(2008) Robin Nathans et al.   NATURE BIOTECHNOLOGY

HIV-1 Vif, APOBEC, and Intrinsic Immunity

(2008) Ritu Goila-Gaur et al.   Retrovirology