Cdc73 suppresses genome instability by mediating telomere homeostasis

Pathways and Mechanisms that Prevent Genome Instability in Saccharomyces cerevisiae

(2017) Christopher D. Putnam et al.   GENETICS

Architecture of the RNA polymerase II-Paf1C-TFIIS transcription elongation complex

(2017) Youwei Xu et al.   Nature Communications

Pathways and Mechanisms that Prevent Genome Instability in Saccharomyces cerevisiae

(2017) Christopher D. Putnam et al.   GENETICS

A genetic network that suppresses genome rearrangements in Saccharomyces cerevisiae and contains defects in cancers

(2016) Christopher D. Putnam et al.   Nature Communications

Whole-Exome Sequencing Studies of Parathyroid Carcinomas Reveal NovelPRUNE2Mutations, Distinctive Mutational Spectra Related to APOBEC-Catalyzed DNA Mutagenesis and Mutational Enrichment in Kinases Associated With Cell Migration and Invasion

(2015) Willie Yu et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

The Principal Role of Ku in Telomere Length Maintenance Is Promotion of Est1 Association with Telomeres

(2014) Jaime M. Williams et al.   GENETICS

Mechanisms of genome instability induced by RNA-processing defects

(2014) Yujia A. Chan et al.   TRENDS IN GENETICS

Germline mutations in the PAF1 complex gene CTR9 predispose to Wilms tumour

(2014) Sandra Hanks et al.   Nature Communications

The Reference Genome Sequence of Saccharomyces cerevisiae : Then and Now

(2014) Stacia R. Engel et al.   G3-Genes Genomes Genetics

DNA Repair Pathway Selection Caused by Defects in TEL1, SAE2, and De Novo Telomere Addition Generates Specific Chromosomal Rearrangement Signatures

(2014) Christopher D. Putnam et al.   PLoS Genetics

The Npl3 hnRNP prevents R-loop-mediated transcription-replication conflicts and genome instability

(2013) J. M. Santos-Pereira et al.   GENES & DEVELOPMENT

The Recruitment of theSaccharomyces cerevisiaePaf1 Complex to Active Genes Requires a Domain of Rtf1 That Directly Interacts with the Spt4-Spt5 Complex

(2013) Manasi K. Mayekar et al.   MOLECULAR AND CELLULAR BIOLOGY

The Cancer Genome Atlas Pan-Cancer analysis project

(2013) John N Weinstein et al.   NATURE GENETICS

Structural basis for Spt5-mediated recruitment of the Paf1 complex to chromatin

(2013) A. D. Wier et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Crystallographic analysis of the conserved C-terminal domain of transcription factor Cdc73 fromSaccharomyces cerevisiaereveals a GTPase-like fold

(2012) Hongkai Chen et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

The many roles of the conserved eukaryotic Paf1 complex in regulating transcription, histone modifications, and disease states

(2012) Brett N. Tomson et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Mutually Exclusive Binding of Telomerase RNA and DNA by Ku Alters Telomerase Recruitment Model

(2012) Jennifer S. Pfingsten et al.   CELL

Pol II CTD kinases Bur1 and Kin28 promote Spt5 CTR-independent recruitment of Paf1 complex

(2012) Hongfang Qiu et al.   EMBO JOURNAL

Everything You Ever Wanted to Know About Saccharomyces cerevisiae Telomeres: Beginning to End

(2012) R. J. Wellinger et al.   GENETICS

Cdc73 Subunit of Paf1 Complex Contains C-terminal Ras-like Domain That Promotes Association of Paf1 Complex with Chromatin

(2012) Christopher G. Amrich et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Preventing Replication Stress to Maintain Genome Stability: Resolving Conflicts between Replication and Transcription

(2012) Rodrigo Bermejo et al.   MOLECULAR CELL

R Loops: From Transcription Byproducts to Threats to Genome Stability

(2012) Andrés Aguilera et al.   MOLECULAR CELL

Transcription as a source of genome instability

(2012) Nayun Kim et al.   NATURE REVIEWS GENETICS

Bioinformatic identification of genes suppressing genome instability

(2012) C. D. Putnam et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural and Functional Discussion of the Tetra-Trico-Peptide Repeat, a Protein Interaction Module

(2012) Natalie Zeytuni et al.   STRUCTURE

Rapid Analysis of Saccharomyces cerevisiae Genome Rearrangements by Multiplex Ligation–Dependent Probe Amplification

(2012) Jason E. Chan et al.   PLoS Genetics

TERRA Promotes Telomere Shortening through Exonuclease 1–Mediated Resection of Chromosome Ends

(2012) Verena Pfeiffer et al.   PLoS Genetics

Karyotypic Determinants of Chromosome Instability in Aneuploid Budding Yeast

(2012) Jin Zhu et al.   PLoS Genetics

Genome-wide function of THO/TREX in active genes prevents R-loop-dependent replication obstacles

(2011) Belén Gómez-González et al.   EMBO JOURNAL

A novel assay identifies transcript elongation roles for the Nup84 complex and RNA processing factors

(2011) Cristina Tous et al.   EMBO JOURNAL

Subtelomeric repetitive elements determine TERRA regulation by Rap1/Rif and Rap1/Sir complexes in yeast

(2011) Nahid Iglesias et al.   EMBO REPORTS

CDC73-related hereditary hyperparathyroidism: five new mutations and the clinical spectrum

(2011) Karin Frank-Raue et al.   EUROPEAN JOURNAL OF ENDOCRINOLOGY

Detection of the first gross CDC73 germline deletion in an HPT-JT syndrome family

(2011) Alberto Cascón et al.   GENES CHROMOSOMES & CANCER

RNase H and Multiple RNA Biogenesis Factors Cooperate to Prevent RNA:DNA Hybrids from Generating Genome Instability

(2011) Lamia Wahba et al.   MOLECULAR CELL

A Common Telomeric Gene Silencing Assay Is Affected by Nucleotide Metabolism

(2011) Marlies P. Rossmann et al.   MOLECULAR CELL

Aneuploidy Drives a Mutator Phenotype in Cancer

(2011) R. D. Kolodner et al.   SCIENCE

A Genetic and Structural Study of Genome Rearrangements Mediated by High Copy Repeat Ty1 Elements

(2011) Jason E. Chan et al.   PLoS Genetics

The Paf1 complex: Platform or player in RNA polymerase II transcription?

(2010) Judith A. Jaehning   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

The Human PAF1 Complex Acts in Chromatin Transcription Elongation Both Independently and Cooperatively with SII/TFIIS

(2010) Jaehoon Kim et al.   CELL

TERRA biogenesis, turnover and implications for function

(2010) Sascha Feuerhahn et al.   FEBS LETTERS

Cell division cycle protein 73 homolog (CDC73) mutations in the hyperparathyroidism-jaw tumor syndrome (HPT-JT) and parathyroid tumors

(2010) Paul J. Newey et al.   HUMAN MUTATION

Leo1 Subunit of the Yeast Paf1 Complex Binds RNA and Contributes to Complex Recruitment

(2010) Jessica L. Dermody et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Comprehensive and quantitative analysis of yeast deletion mutants defective in apical and isotropic bud growth

(2009) Machika Watanabe et al.   CURRENT GENETICS

Parafibromin - functional insights

(2009) P. J. Newey et al.   JOURNAL OF INTERNAL MEDICINE

Specific pathways prevent duplication-mediated genome rearrangements

(2009) Christopher D. Putnam et al.   NATURE

A genome-wide screen for essential yeast genes that affect telomere length maintenance

(2009) L. Ungar et al.   NUCLEIC ACIDS RESEARCH

Stabilization of Dicentric Translocations through Secondary Rearrangements Mediated by Multiple Mechanisms in S. cerevisiae

(2009) Vincent Pennaneach et al.   PLoS One

The Paf1 complex is required for efficient transcription elongation by RNA polymerase I

(2009) Y. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ultrafast and memory-efficient alignment of short DNA sequences to the human genome

(2009) Ben Langmead et al.   GENOME BIOLOGY

TLC1 RNA nucleo-cytoplasmic trafficking links telomerase biogenesis to its recruitment to telomeres

(2008) Franck Gallardo et al.   EMBO JOURNAL

Direct Interactions between the Paf1 Complex and a Cleavage and Polyadenylation Factor Are Revealed by Dissociation of Paf1 from RNA Polymerase II

(2008) Kristen Nordick et al.   EUKARYOTIC CELL

Six Classes of Nuclear Localization Signals Specific to Different Binding Grooves of Importin α

(2008) Shunichi Kosugi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Multiple Yeast Genes, Including Paf1 Complex Genes, Affect Telomere Length via Telomerase RNA Abundance

(2008) A. D. Mozdy et al.   MOLECULAR AND CELLULAR BIOLOGY

A systems-level approach to mapping the telomere length maintenance gene circuitry

(2008) Rafi Shachar et al.   Molecular Systems Biology