Structural centrosome aberrations sensitize polarized epithelia to basal cell extrusion

Cell Extrusion: A Stress-Responsive Force for Good or Evil in Epithelial Homeostasis

(2018) Shizue Ohsawa et al.   DEVELOPMENTAL CELL

Structural centrosome aberrations promote non‐cell‐autonomous invasiveness

(2018) Olivier Ganier et al.   EMBO JOURNAL

Once and only once: mechanisms of centriole duplication and their deregulation in disease

(2018) Erich A. Nigg et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

CEP131 indicates poor prognosis and promotes cell proliferation and migration in hepatocellular carcinoma

(2017) Xu-Hui Liu et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Topological defects in epithelia govern cell death and extrusion

(2017) Thuan Beng Saw et al.   NATURE

USP9X regulates centrosome duplication and promotes breast carcinogenesis

(2017) Xin Li et al.   Nature Communications

p120 Catenin Suppresses Basal Epithelial Cell Extrusion in Invasive Pancreatic Neoplasia

(2016) A. M. Hendley et al.   CANCER RESEARCH

Plk4 Promotes Cancer Invasion and Metastasis through Arp2/3 Complex Regulation of the Actin Cytoskeleton

(2016) Karineh Kazazian et al.   CANCER RESEARCH

Droplet organelles?

(2016) Edward M Courchaine et al.   EMBO JOURNAL

Transient PLK4 overexpression accelerates tumorigenesis in p53-deficient epidermis

(2015) Özdemirhan Serçin et al.   NATURE CELL BIOLOGY

Centrosome function and assembly in animal cells

(2015) Paul T. Conduit et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Structural centrosome aberrations favor proliferation by abrogating microtubule-dependent tissue integrity of breast epithelial mammospheres

(2015) D Schnerch et al.   ONCOGENE

The Centrosome and Its Duplication Cycle

(2015) Jingyan Fu et al.   Cold Spring Harbor Perspectives in Biology

Detyrosinated microtubules modulate mechanotransduction in heart and skeletal muscle

(2015) Jaclyn P. Kerr et al.   Nature Communications

p38- and MK2-dependent signalling promotes stress-induced centriolar satellite remodelling via 14-3-3-dependent sequestration of CEP131/AZI1

(2015) Maxim A. X. Tollenaere et al.   Nature Communications

Over-expression of Plk4 induces centrosome amplification, loss of primary cilia and associated tissue hyperplasia in the mouse

(2015) Paula A. Coelho et al.   Open Biology

Defective apical extrusion signaling contributes to aggressive tumor hallmarks

(2015) Yapeng Gu et al.   eLife

Oncogene-like induction of cellular invasion from centrosome amplification

(2014) Susana A. Godinho et al.   NATURE

Causes and consequences of centrosome abnormalities in cancer

(2014) S. A. Godinho et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

The centriole duplication cycle

(2014) E. N. F rat-Karalar et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Pericentriolar material structure and dynamics

(2014) J. B. Woodruff et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Centrosomes are autocatalytic droplets of pericentriolar material organized by centrioles

(2014) David Zwicker et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Centriolar Satellite Protein AZI1 Interacts with BBS4 and Regulates Ciliary Trafficking of the BBSome

(2014) Xitiz Chamling et al.   PLoS Genetics

A sphingosine 1-phosphate receptor 2 selective allosteric agonist

(2013) Hideo Satsu et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Small Molecules CK-666 and CK-869 Inhibit Actin-Related Protein 2/3 Complex by Blocking an Activating Conformational Change

(2013) Byron Hetrick et al.   CHEMISTRY & BIOLOGY

Autophagy in Oncogenic K-Ras Promotes Basal Extrusion of Epithelial Cells by Degrading S1P

(2013) Gloria Slattum et al.   CURRENT BIOLOGY

Phase transitions and size scaling of membrane-less organelles

(2013) Clifford P. Brangwynne   JOURNAL OF CELL BIOLOGY

Caspase Functions in Cell Death and Disease

(2013) D. R. McIlwain et al.   Cold Spring Harbor Perspectives in Biology

Acute Versus Chronic Loss of Mammalian Azi1/Cep131 Results in Distinct Ciliary Phenotypes

(2013) Emma A. Hall et al.   PLoS Genetics

The centriolar satellite protein Cep131 is important for genome stability

(2012) C. J. Staples et al.   JOURNAL OF CELL SCIENCE

Towards a molecular architecture of centriole assembly

(2012) Pierre Gönczy   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The Centrosome in Cells and Organisms

(2012) M. Bornens   SCIENCE

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

The tumor suppressor adenomatous polyposis coli controls the direction in which a cell extrudes from an epithelium

(2011) Thomas W. Marshall et al.   MOLECULAR BIOLOGY OF THE CELL

Centrosomes and cilia in human disease

(2011) Mónica Bettencourt-Dias et al.   TRENDS IN GENETICS

Centrosomal Nlp is an oncogenic protein that is gene-amplified in human tumors and causes spontaneous tumorigenesis in transgenic mice

(2010) Shujuan Shao et al.   JOURNAL OF CLINICAL INVESTIGATION

Cep70 and Cep131 contribute to ciliogenesis in zebrafish embryos

(2009) Christopher J Wilkinson et al.   BMC CELL BIOLOGY

Aurora B-Mediated Abscission Checkpoint Protects against Tetraploidization

(2009) Patrick Steigemann et al.   CELL

Cep76, a Centrosomal Protein that Specifically Restrains Centriole Reduplication

(2009) William Y. Tsang et al.   DEVELOPMENTAL CELL

P115 RhoGEF and microtubules decide the direction apoptotic cells extrude from an epithelium

(2009) Gloria Slattum et al.   JOURNAL OF CELL BIOLOGY

A mechanism linking extra centrosomes to chromosomal instability

(2009) Neil J. Ganem et al.   NATURE

Multipolar Spindle Pole Coalescence Is a Major Source of Kinetochore Mis-Attachment and Chromosome Mis-Segregation in Cancer Cells

(2009) William T. Silkworth et al.   PLoS One

Centrosome Amplification Can Initiate Tumorigenesis in Flies

(2008) Renata Basto et al.   CELL