The SKP1-Cullin-F-box E3 ligase βTrCP and CDK2 cooperate to control STIL abundance and centriole number

Once and only once: mechanisms of centriole duplication and their deregulation in disease

(2018) Erich A. Nigg et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The development and functions of multiciliated epithelia

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Mitotic spindle assembly in animal cells: a fine balancing act

(2017) Suzanna L. Prosser et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The Cilium: Cellular Antenna and Central Processing Unit

(2017) Jarema J. Malicki et al.   TRENDS IN CELL BIOLOGY

APC/C FZR-1 Controls SAS-5 Levels To Regulate Centrosome Duplication in Caenorhabditis elegans

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The PLK4–STIL–SAS-6 module at the core of centriole duplication

(2016) Christian Arquint et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Quantitative analysis of human centrosome architecture by targeted proteomics and fluorescence imaging

(2016) Manuel Bauer et al.   EMBO JOURNAL

Evaluation and Improvement of Quantification Accuracy in Isobaric Mass Tag-Based Protein Quantification Experiments

(2016) Erik Ahrné et al.   JOURNAL OF PROTEOME RESEARCH

2016 update of the PRIDE database and its related tools

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Cep295 is a conserved scaffold protein required for generation of a bona fide mother centriole

(2016) Yuki Tsuchiya et al.   Nature Communications

A Dynamic Protein Interaction Landscape of the Human Centrosome-Cilium Interface

(2015) Gagan D. Gupta et al.   CELL

Ubiquitin, the centrosome, and chromosome segregation

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Binding of STIL to Plk4 activates kinase activity to promote centriole assembly

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Transient PLK4 overexpression accelerates tumorigenesis in p53-deficient epidermis

(2015) Özdemirhan Serçin et al.   NATURE CELL BIOLOGY

Conserved molecular interactions in centriole-to-centrosome conversion

(2015) Jingyan Fu et al.   NATURE CELL BIOLOGY

Centrosome function and assembly in animal cells

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Structural centrosome aberrations favor proliferation by abrogating microtubule-dependent tissue integrity of breast epithelial mammospheres

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The Centrosome and Its Duplication Cycle

(2015) Jingyan Fu et al.   Cold Spring Harbor Perspectives in Biology

Over-expression of Plk4 induces centrosome amplification, loss of primary cilia and associated tissue hyperplasia in the mouse

(2015) Paula A. Coelho et al.   Open Biology

STIL binding to Polo-box 3 of PLK4 regulates centriole duplication

(2015) Christian Arquint et al.   eLife

Plk4-dependent phosphorylation of STIL is required for centriole duplication

(2015) A.-S. Kratz et al.   Biology Open

Plk4 Phosphorylates Ana2 to Trigger Sas6 Recruitment and Procentriole Formation

(2014) Nikola S. Dzhindzhev et al.   CURRENT BIOLOGY

STIL Microcephaly Mutations Interfere with APC/C-Mediated Degradation and Cause Centriole Amplification

(2014) Christian Arquint et al.   CURRENT BIOLOGY

Oncogene-like induction of cellular invasion from centrosome amplification

(2014) Susana A. Godinho et al.   NATURE

Separate to operate: control of centrosome positioning and separation

(2014) F. G. Agircan et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

The centriole duplication cycle

(2014) E. N. F rat-Karalar et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Small organelle, big responsibility: the role of centrosomes in development and disease

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Centrosomes as signalling centres

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Direct interaction of Plk4 with STIL ensures formation of a single procentriole per parental centriole

(2014) Midori Ohta et al.   Nature Communications

Stabilization of Cartwheel-less Centrioles for Duplication Requires CEP295-Mediated Centriole-to-Centrosome Conversion

(2014) Denisse Izquierdo et al.   Cell Reports

Human Cep192 and Cep152 cooperate in Plk4 recruitment and centriole duplication

(2013) K. F. Sonnen et al.   JOURNAL OF CELL SCIENCE

USP33 regulates centrosome biogenesis via deubiquitination of the centriolar protein CP110

(2013) Ji Li et al.   NATURE

Centrosome amplification causes microcephaly

(2013) Véronique Marthiens et al.   NATURE CELL BIOLOGY

Hierarchical recruitment of Plk4 and regulation of centriole biogenesis by two centrosomal scaffolds, Cep192 and Cep152

(2013) T.-S. Kim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural Analysis of the G-Box Domain of the Microcephaly Protein CPAP Suggests a Role in Centriole Architecture

(2013) Georgios N. Hatzopoulos et al.   STRUCTURE

Crystal structures of the CPAP/STIL complex reveal its role in centriole assembly and human microcephaly

(2013) Matthew A Cottee et al.   eLife

Novel E3 ligase component FBXL7 ubiquitinates and degrades Aurora A, causing mitotic arrest

(2012) Tiffany A. Coon et al.   CELL CYCLE

Kendrin Is a Novel Substrate for Separase Involved in the Licensing of Centriole Duplication

(2012) Kazuhiko Matsuo et al.   CURRENT BIOLOGY

Supernumerary Centrosomes Nucleate Extra Cilia and Compromise Primary Cilium Signaling

(2012) Moe R. Mahjoub et al.   CURRENT BIOLOGY

The autoregulated instability of Polo-like kinase 4 limits centrosome duplication to once per cell cycle

(2012) A. J. Holland et al.   GENES & DEVELOPMENT

Meier-Gorlin syndrome mutations disrupt an Orc1 CDK inhibitory domain and cause centrosome reduplication

(2012) M. Hossain et al.   GENES & DEVELOPMENT

The transition from meiotic to mitotic spindle assembly is gradual during early mammalian development

(2012) Aurélien Courtois et al.   JOURNAL OF CELL BIOLOGY

Cell-cycle-regulated expression of STIL controls centriole number in human cells

(2012) C. Arquint et al.   JOURNAL OF CELL SCIENCE

STIL is required for centriole duplication in human cells

(2012) J. Vulprecht et al.   JOURNAL OF CELL SCIENCE

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(2012) Amelia C. Peterson et al.   MOLECULAR & CELLULAR PROTEOMICS

OMERO: flexible, model-driven data management for experimental biology

(2012) Chris Allan et al.   NATURE METHODS

Towards a molecular architecture of centriole assembly

(2012) Pierre Gönczy   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The Centrosome in Cells and Organisms

(2012) M. Bornens   SCIENCE

3D-structured illumination microscopy provides novel insight into architecture of human centrosomes

(2012) Katharina F. Sonnen et al.   Biology Open

The human microcephaly protein STIL interacts with CPAP and is required for procentriole formation

(2011) Chieh-Ju C Tang et al.   EMBO JOURNAL

The conversion of centrioles to centrosomes: essential coupling of duplication with segregation

(2011) Won-Jing Wang et al.   JOURNAL OF CELL BIOLOGY

The centrosome cycle: Centriole biogenesis, duplication and inherent asymmetries

(2011) Erich A. Nigg et al.   NATURE CELL BIOLOGY

The SCF–FBXW5 E3-ubiquitin ligase is regulated by PLK4 and targets HsSAS-6 to control centrosome duplication

(2011) Anja Puklowski et al.   NATURE CELL BIOLOGY

Cubism and the cell cycle: the many faces of the APC/C

(2011) Jonathon Pines   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Ciliogenesis: building the cell's antenna

(2011) Hiroaki Ishikawa et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Polo-like kinase 4 kinase activity limits centrosome overduplication by autoregulating its own stability

(2010) Andrew J. Holland et al.   JOURNAL OF CELL BIOLOGY

Plk4 trans-autophosphorylation regulates centriole number by controlling  TrCP-mediated degradation

(2010) G. Guderian et al.   JOURNAL OF CELL SCIENCE

SCFCyclin F controls centrosome homeostasis and mitotic fidelity through CP110 degradation

(2010) Vincenzo D’Angiolella et al.   NATURE

Asterless is a scaffold for the onset of centriole assembly

(2010) Nikola S. Dzhindzhev et al.   NATURE

Control of Centriole Length by CPAP and CP110

(2009) Thorsten I. Schmidt et al.   CURRENT BIOLOGY

Polo Kinase and Separase Regulate the Mitotic Licensing of Centriole Duplication in Human Cells

(2009) Meng-Fu Bryan Tsou et al.   DEVELOPMENTAL CELL

The SCFSlimbubiquitin ligase regulates Plk4/Sak levels to block centriole reduplication

(2009) Gregory C. Rogers et al.   JOURNAL OF CELL BIOLOGY

A mechanism linking extra centrosomes to chromosomal instability

(2009) Neil J. Ganem et al.   NATURE

CPAP is a cell-cycle regulated protein that controls centriole length

(2009) Chieh-Ju C. Tang et al.   NATURE CELL BIOLOGY

Multipolar Spindle Pole Coalescence Is a Major Source of Kinetochore Mis-Attachment and Chromosome Mis-Segregation in Cancer Cells

(2009) William T. Silkworth et al.   PLoS One

Centrosome Amplification Can Initiate Tumorigenesis in Flies

(2008) Renata Basto et al.   CELL

Plk1 regulates mitotic Aurora A function through βTrCP-dependent degradation of hBora

(2008) Eunice H. Y. Chan et al.   CHROMOSOMA

The SCF/Slimb Ubiquitin Ligase Limits Centrosome Amplification through Degradation of SAK/PLK4

(2008) Inês Cunha-Ferreira et al.   CURRENT BIOLOGY

The mitotic checkpoint gene,SILis regulated byE2F1

(2008) Ayelet Erez et al.   INTERNATIONAL JOURNAL OF CANCER