RNAseq analysis of bronchial epithelial cells to identify COPD-associated genes and SNPs

Genetic effects on gene expression across human tissues

(2017) François Aguet et al.   NATURE

Genome-wide association analyses for lung function and chronic obstructive pulmonary disease identify new loci and potential druggable targets

(2017) Louise V Wain et al.   NATURE GENETICS

Integrated Genomics Reveals Convergent Transcriptomic Networks Underlying Chronic Obstructive Pulmonary Disease and Idiopathic Pulmonary Fibrosis

(2016) Rebecca L. Kusko et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Exome Sequencing Analysis in Severe, Early-Onset Chronic Obstructive Pulmonary Disease

(2016) Dandi Qiao et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Discovering Single Nucleotide Polymorphisms Regulating Human Gene Expression Using Allele Specific Expression from RNA-seq Data

(2016) E. Y. Kang et al.   GENETICS

Multivariate eQTL mapping uncovers functional variation on the X-chromosome associated with complex disease traits

(2016) Ben M. Brumpton et al.   HUMAN GENETICS

Haplotype and diplotype analyses of variation in ERCC5 transcription cis-regulation in normal bronchial epithelial cells

(2016) Xiaolu Zhang et al.   PHYSIOLOGICAL GENOMICS

Association of breast cancer risk with genetic variants showing differential allelic expression: Identification of a novel breast cancer susceptibility locus at 4q21

(2016) Yosr Hamdi et al.   Oncotarget

Lung cancer risk test trial: study design, participant baseline characteristics, bronchoscopy safety, and establishment of a biospecimen repository

(2016) E. L. Crawford et al.   BMC Pulmonary Medicine

p73 Is Required for Multiciliogenesis and Regulates the Foxj1-Associated Gene Network

(2016) Clayton B. Marshall et al.   Cell Reports

An integrated map of structural variation in 2,504 human genomes

(2015) Peter H. Sudmant et al.   NATURE

The role of regulatory variation in complex traits and disease

(2015) Frank W. Albert et al.   NATURE REVIEWS GENETICS

The Genotype-Tissue Expression (GTEx) pilot analysis: Multitissue gene regulation in humans

(2015) et al.   SCIENCE

Abnormalities in Airway Epithelial Junction Formation in Chronic Obstructive Pulmonary Disease

(2014) Irene H. Heijink et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Genetic control of gene expression at novel and established chronic obstructive pulmonary disease loci

(2014) Peter J. Castaldi et al.   HUMAN MOLECULAR GENETICS

Association of genes involved in nicotine and tobacco smoke toxicant metabolism (CHRNA3/5, CYP2A6, and NQO1) and DNA repair (XRCC1, XRCC3, XPC, and XPA) with chronic obstructive pulmonary disease

(2014) G. F. Korytina et al.   MOLECULAR BIOLOGY

The UCSC Genome Browser database: 2015 update

(2014) Kate R. Rosenbloom et al.   NUCLEIC ACIDS RESEARCH

deltaNp63 Has a Role in Maintaining Epithelial Integrity in Airway Epithelium

(2014) Ari Jon Arason et al.   PLoS One

A Multiplex Two-Color Real-Time PCR Method for Quality-Controlled Molecular Diagnostic Testing of FFPE Samples

(2014) Jiyoun Yeo et al.   PLoS One

Risk loci for chronic obstructive pulmonary disease: a genome-wide association study and meta-analysis

(2014) Michael H Cho et al.   Lancet Respiratory Medicine

A Dynamic Bronchial Airway Gene Expression Signature of Chronic Obstructive Pulmonary Disease and Lung Function Impairment

(2013) Katrina Steiling et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Heritability of Chronic Obstructive Pulmonary Disease and Related Phenotypes in Smokers

(2013) Jin J. Zhou et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Transcription Factor p63 Regulates Key Genes and Wound Repair in Human Airway Epithelial Basal Cells

(2013) Stephanie M. B. Warner et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Smoking-Induced CXCL14 Expression in the Human Airway Epithelium Links Chronic Obstructive Pulmonary Disease to Lung Cancer

(2013) Renat Shaykhiev et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Evaluation of DNA damage in COPD patients and its correlation with polymorphisms in repair genes

(2013) Andréa Lúcia Gonçalves da Silva et al.   BMC Medical Genetics

Cellular and Molecular Mechanisms of Chronic Obstructive Pulmonary Disease

(2013) Peter J. Barnes   CLINICS IN CHEST MEDICINE

Functional Haplotypes in the Promoter Region of Transcription FactorNrf2in Chronic Obstructive Pulmonary Disease

(2013) Chung-Ching Hua et al.   DISEASE MARKERS

Combined Analysis of EPHX1, GSTP1, GSTM1 and GSTT1 Gene Polymorphisms in Relation to Chronic Obstructive Pulmonary Disease Risk and Lung Function Impairment

(2013) Ramzi Lakhdar et al.   DISEASE MARKERS

Genetic variation in antioxidant enzymes, cigarette smoking, and longitudinal change in lung function

(2013) Wenbo Tang et al.   FREE RADICAL BIOLOGY AND MEDICINE

Targeted RNA-Sequencing with Competitive Multiplex-PCR Amplicon Libraries

(2013) Thomas M. Blomquist et al.   PLoS One

Massively parallel in vivo enhancer assay reveals that highly local features determine the cis-regulatory function of ChIP-seq peaks

(2013) M. A. White et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Global Strategy for the Diagnosis, Management, and Prevention of Chronic Obstructive Pulmonary Disease

(2012) Jørgen Vestbo et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

MirSNP, a database of polymorphisms altering miRNA target sites, identifies miRNA-related SNPs in GWAS SNPs and eQTLs

(2012) Chenxing Liu et al.   BMC GENOMICS

 Np63 knockout mice reveal its indispensable role as a master regulator of epithelial development and differentiation

(2012) R.-A. Romano et al.   DEVELOPMENT

Genetic variation in antioxidant enzymes and lung function

(2012) Amy R. Bentley et al.   FREE RADICAL BIOLOGY AND MEDICINE

Annotation of functional variation in personal genomes using RegulomeDB

(2012) A. P. Boyle et al.   GENOME RESEARCH

Systematic dissection and optimization of inducible enhancers in human cells using a massively parallel reporter assay

(2012) Alexandre Melnikov et al.   NATURE BIOTECHNOLOGY

Genetics of gene expression in primary immune cells identifies cell type–specific master regulators and roles of HLA alleles

(2012) Benjamin P Fairfax et al.   NATURE GENETICS

Mapping cis- and trans-regulatory effects across multiple tissues in twins

(2012) Elin Grundberg et al.   NATURE GENETICS

Polymorphisms in the ERCC5 Gene and Risk of Esophageal Squamous Cell Carcinoma (ESCC) in Eastern Chinese Populations

(2012) Mei-Ling Zhu et al.   PLoS One

Powerful Identification of Cis-regulatory SNPs in Human Primary Monocytes Using Allele-Specific Gene Expression

(2012) Jonas Carlsson Almlöf et al.   PLoS One

Complex effects of nucleotide variants in a mammalian cis-regulatory element

(2012) J. C. Kwasnieski et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Systematic Localization of Common Disease-Associated Variation in Regulatory DNA

(2012) M. T. Maurano et al.   SCIENCE

Updates on the COPD gene list

(2012) Yohan Bosse   International Journal of Chronic Obstructive Pulmonary Disease

The State of Genome-Wide Association Studies in Pulmonary Disease

(2011) Jamie L. Todd et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

A powerful and flexible statistical framework for testing hypotheses of allele-specific gene expression from RNA-seq data

(2011) D. A. Skelly et al.   GENOME RESEARCH

Measurable impact of RNA quality on gene expression results from quantitative PCR

(2011) Joëlle Vermeulen et al.   NUCLEIC ACIDS RESEARCH

Biologic Phenotyping of the Human Small Airway Epithelial Response to Cigarette Smoking

(2011) Ann E. Tilley et al.   PLoS One

Trans-eQTLs Reveal That Independent Genetic Variants Associated with a Complex Phenotype Converge on Intermediate Genes, with a Major Role for the HLA

(2011) Rudolf S. N. Fehrmann et al.   PLoS Genetics

Multistudy Fine Mapping of Chromosome 2q IdentifiesXRCC5as a Chronic Obstructive Pulmonary Disease Susceptibility Gene

(2010) Craig P. Hersh et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Feature selection in omics prediction problems using cat scores and false nondiscovery rate control

(2010) Miika Ahdesmäki et al.   Annals of Applied Statistics

Cis -acting genetic variation at an E2F1/YY1 response site and putative p53 site is associated with altered allele-specific expression of ERCC5 (XPG) transcript in normal human bronchial epithelium

(2010) Thomas M. Blomquist et al.   CARCINOGENESIS

Polymorphisms in the Superoxide Dismutase-3 Gene Are Associated with Emphysema in COPD

(2010) I. C. Sørheim et al.   COPD-Journal of Chronic Obstructive Pulmonary Disease

Genetic Epidemiology of COPD (COPDGene) Study Design

(2010) Elizabeth A. Regan et al.   COPD-Journal of Chronic Obstructive Pulmonary Disease

Association between polymorphism of glutathione S-transferase P1 and chronic obstructive pulmonary disease: A meta-analysis

(2010) Fugui Yan et al.   RESPIRATORY MEDICINE

Pattern of Antioxidant and DNA Repair Gene Expression in Normal Airway Epithelium Associated with Lung Cancer Diagnosis

(2009) T. Blomquist et al.   CANCER RESEARCH

Lung-specific inactivation of CCAAT/enhancer binding protein   causes a pathological pattern characteristic of COPD

(2009) L. Didon et al.   EUROPEAN RESPIRATORY JOURNAL

Global patterns of cis variation in human cells revealed by high-density allelic expression analysis

(2009) Bing Ge et al.   NATURE GENETICS

Superoxide dismutase 3, extracellular (SOD3) variants and lung function

(2009) Koustav Ganguly et al.   PHYSIOLOGICAL GENOMICS

Common Regulatory Variation Impacts Gene Expression in a Cell Type-Dependent Manner

(2009) A. S. Dimas et al.   SCIENCE

Superoxide Dismutase 3 Polymorphism Associated with Reduced Lung Function in Two Large Populations

(2008) Morten Dahl et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Cigarette Smoke Triggers Code Red

(2008) Rubin M. Tuder et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

p63 in epithelial development

(2008) E. Candi et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Genetics of gene expression and its effect on disease

(2008) Valur Emilsson et al.   NATURE

Mapping the Genetic Architecture of Gene Expression in Human Liver

(2008) Eric E Schadt et al.   PLOS BIOLOGY