Review
Cell Biology
Yuan Liu, Christina Holmes
Summary: This review explores the tissue regeneration potential of EVs isolated from bone marrow and adipose tissue, the two most common clinical sources of adult MSCs, focusing on their angiogenic, osteogenic, and immunomodulatory potentials. Other important issues in the development of MSC-derived EV based therapies are also discussed.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Shun-Cheng Wu, Chih-Hsiang Chang, Ling-Hua Chang, Che-Wei Wu, Jhen-Wei Chen, Chung-Hwan Chen, Yi-Shan Lin, Je-Ken Chang, Mei-Ling Ho
Summary: The study found that simvastatin (SIM) can enhance ADSC-based chondrogenesis in the presence of hyaluronan (HA) microenvironment (HAM) while avoiding osteogenesis.
Article
Biochemistry & Molecular Biology
Amarildo Smakaj, Domenico De Mauro, Giuseppe Rovere, Silvia Pietramala, Giulio Maccauro, Ornella Parolini, Wanda Lattanzi, Francesco Liuzza
Summary: Non-union fractures are a challenging orthopedic issue with significant socio-economic impact globally. Recent focus has been on the use of adipose-derived stem cells (ADSCs) for the treatment of such fractures, with promising results in bone regenerative medicine. Further research is needed to fully understand the translational potential of ADSC therapies and address critical issues for their widespread clinical application.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Mei-Ling Ho, Chin-Jung Hsu, Che-Wei Wu, Ling-Hua Chang, Jhen-Wei Chen, Chung-Hwan Chen, Kui-Chou Huang, Je-Ken Chang, Shun-Cheng Wu, Pei-Lin Shao
Summary: This study investigated the effect of adipose-derived stem cell (ADSC)-secreted extracellular vesicles (EVs) on osteoblast function. The results showed that ADSC-EVs can enhance osteoblast proliferation and activity, and may regulate osteoblast function through autophagy or signaling pathways.
Article
Biochemistry & Molecular Biology
Tongtong Chen, Hanqi Wang, Chaoyin Jiang, Yong Lu
Summary: This study reveals that under oxidative stress conditions, PKD1 may alleviate the inhibitory effect of oxidative stress on osteogenesis of rat BM-MSCs through TAZ activation.
JOURNAL OF CELLULAR BIOCHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Szu-Hsien Wu, Yu-Ting Liao, Chi-Han Huang, Yi-Chou Chen, En-Rung Chiang, Jung-Pan Wang
Summary: ADSCs tend to spontaneously differentiate into neuron-like cells during high confluence culture, with enhanced expression of neuronal markers and neurotrophins, while BMSCs do not show this tendency. Additionally, ADSCs do not exhibit spontaneous adipogenic and osteogenic differentiation during this process.
Article
Biochemistry & Molecular Biology
Wan'an Xiao, Quang Le, Di Zhu, Abhijit Dighe, Quanjun Cui, Xinlin Yang
Summary: This study investigated the role of Fpr1 gene in osteogenic and adipogenic differentiation of adipose derived stem cells (ADSCs), finding a correlation of Fpr1 gene expression with osteogenesis and adipogenesis, involving the nuclear transcription factor FoxO1. Targeting Fpr1 could be a novel strategy to enhance osteogenesis of ADSCs.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Cell & Tissue Engineering
Mingjiao Chen, Meng Zhou, Yao Fu, Jin Li, Zi Wang
Summary: BMP2 can promote angiogenesis of ADSCs by stimulating the expression of miR-672. MiR-672 acts as a positive regulator of ADSCs angiogenesis, and incorporating miR-672-modified ADSCs into calcium phosphate cement can significantly enhance vascularization and bone regeneration.
STEM CELL RESEARCH & THERAPY
(2021)
Article
Endocrinology & Metabolism
Yi Liu, Zihan Wang, Mingyan Ju, Yuxia Zhao, Yaqing Jing, Jiaci Li, Chenyi Shao, Ting Fu, Zhe Lv, Guang Li
Summary: Osteogenesis imperfecta is a congenital genetic disorder characterized by bone fragility and recurrent fractures, mainly caused by mutations in COL1A1/COL1A2 genes. Research has shown that modifying the COL1A1 gene can restore the bone-forming capacity of defective ADSCs, improving bone microstructure and promoting bone formation in mice.
JOURNAL OF BONE AND MINERAL RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Siti Syahira Airuddin, Ahmad Sukari Halim, Wan Azman Wan Sulaiman, Ramlah Kadir, Nur Azida Mohd Nasir
Summary: Stem cells, particularly adipose-derived stem cells, have shown promising potential in disease treatment due to their differentiation abilities and secretion of growth factors. However, more research is needed to fully understand the safety and effectiveness of adipose-derived stem cells in medical treatment.
Article
Biochemistry & Molecular Biology
Lara Milian, Pilar Molina, Maria Oliver-Ferrandiz, Carlos Fernandez-Sellers, Ana Monzo, Rafael Sanchez-Sanchez, Aitana Braza-Boils, Manuel Mata, Esther Zorio
Summary: This study found the feasibility of isolating and characterizing adipose-derived stem cells (ADSCs) from cadaveric samples, and confirmed their ability to differentiate into chondrocytes and osteocytes. This discovery provides potential applications in tissue engineering and research fields.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Pharmacology & Pharmacy
Michiko Horiguchi, Yuya Tsurudome, Kentaro Ushijima
Summary: This study reveals that AMFR and DCTN2 genes reduce the transplantation efficiency of T1DM ADSCs, and decreasing their expression can improve transplant outcomes.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Ruijing Chen, Taojin Feng, Shi Cheng, Ming Chen, Yi Li, Zihui Yu, Ziying Xu, Pengbin Yin, Licheng Zhang, Peifu Tang
Summary: Exosomes derived from human adipose-derived stem cells (hADSCs) can preferentially accumulate at bone, especially at the calvarial defect site, when intravenously injected. Exosomes treatment promotes osteogenesis and bone defect repair. Moreover, exosomes from 3D-cultured hADSCs exhibit superior bone-targeting effects and repair capacity compared to those derived from 2D-cultured hADSCs.
Article
Engineering, Biomedical
Fanglin Wang, Qiao Wang, Yu Zhao, Zhiyu Tian, Shijie Chang, Hao Tong, Ningwei Liu, Shuling Bai, Xiang Li, Jun Fan
Summary: This study investigated the role of miR-150-5p and its related mechanisms in the osteogenesis of adipose-derived mesenchymal stem cells (ADSCs). The results showed that miR-150-5p regulates Notch3 during ADSCs osteogenesis. It was found that inhibition of miR-150-5p enhanced the osteogenic capacity of ADSCs, and partially reversed the inhibition effect of Notch3 knockdown on osteogenesis.
ACTA BIOMATERIALIA
(2023)
Article
Polymer Science
Banafsheh Safari, Marziyeh Aghazadeh, Leila Roshangar, Ayuob Aghanejad, Soodabeh Davaran
Summary: This study reports the fabrication and evaluation of a bioactive hybrid scaffold collagen/P-PCL for bone tissue engineering. The scaffold showed biocompatibility, osteoconductivity, and osteoinductivity, supporting the proliferation and differentiation of AD-MSCs.
EUROPEAN POLYMER JOURNAL
(2022)
Article
Cell & Tissue Engineering
Rongyao Xu, Guanghui Shi, Ling Xu, Qinyi Gu, Yu Fu, Ping Zhang, Jie Cheng, Hongbing Jiang
JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE
(2018)
Article
Dentistry, Oral Surgery & Medicine
Guangnan Li, Haoliang Qian, Songsong Guo, Dongmiao Wang, Chao Sun, Yifei Du, Jie Cheng, Hongbing Jiang
Review
Virology
Hongbing Jiang, David Wang
Article
Biochemistry & Molecular Biology
Weiwen Zhu, Rongyao Xu, Jinying Du, Yu Fu, Sheng Li, Ping Zhang, Laikui Liu, Hongbing Jiang
Article
Biochemistry & Molecular Biology
Ling Xu, Yu Fu, Weiwen Zhu, Rongyao Xu, Juan Zhang, Ping Zhang, Jie Cheng, Hongbing Jiang
JOURNAL OF CELLULAR BIOCHEMISTRY
(2019)
Article
Cell & Tissue Engineering
Tao Xiao, Yu Fu, Weiwen Zhu, Rongyao Xu, Ling Xu, Ping Zhang, Yifei Du, Jie Cheng, Hongbing Jiang
STEM CELLS TRANSLATIONAL MEDICINE
(2019)
Article
Surgery
Yue Song, Jiaan Hu, Yaping Wu, Dongmiao Wang, Yanling Wang, Ping Zhang, Hongbing Jiang, Jianrong Yang, Jie Cheng
JOURNAL OF CRANIOFACIAL SURGERY
(2019)
Article
Dentistry, Oral Surgery & Medicine
Xiaotong He, Jiayi He, Hua Yuan, Wenjing Chen, Hongbing Jiang, Jie Cheng
JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY
(2019)
Article
Oncology
Chen Zhou, Pengfei Diao, Yaping Wu, Zicheng Wei, Lei Jiang, Wei Zhang, Zhongwu Li, Jinhai Ye, Xiaomeng Song, Heming Wu, Hongbing Pang, Yanling Wang, Jie Cheng
INTERNATIONAL JOURNAL OF CANCER
(2020)
Article
Oncology
Xue Liu, Yu Fu, Jiadong Huang, Meng Wu, Zhenxing Zhang, Rongyao Xu, Ping Zhang, Shouwei Zhao, Laikui Liu, Hongbing Jiang
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2019)
Article
Cell Biology
Jin Li, Zhongwu Li, Yaping Wu, Yanling Wang, Dongmiao Wang, Wei Zhang, Hua Yuan, Jinhai Ye, Xiaomeng Song, Jianrong Yang, Hongbing Jiang, Jie Cheng
CELL DEATH & DISEASE
(2019)
Article
Environmental Sciences
Shuying Li, Hongbing Jiang, Kun Qiao, Wenjun Gui, Guonian Zhu
Review
Cell Biology
Lingfei Zhao, Chenxia Hu, Ping Zhang, Hua Jiang, Jianghua Chen
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2020)
Article
Medicine, Research & Experimental
Yaping Wu, Yanling Wang, Pengfei Diao, Wei Zhang, Jin Li, Han Ge, Yue Song, Zhongwu Li, Dongmiao Wang, Laikui Liu, Hongbing Jiang, Jie Cheng