HDAC8, A Potential Therapeutic Target, Regulates Proliferation and Differentiation of Bone Marrow Stromal Cells in Fibrous Dysplasia

Celecoxib treatment of fibrous dysplasia (FD) in a human FD cell line and FD-like lesions in mice with protein kinase A (PKA) defects

(2017) Emmanouil Saloustros et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Expression of an active Gαsmutant in skeletal stem cells is sufficient and necessary for fibrous dysplasia initiation and maintenance

(2017) Xuefeng Zhao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

InducedGnasR201Hexpression from the endogenousGnaslocus causes fibrous dysplasia by up-regulating Wnt/β-catenin signaling

(2017) Sanjoy Kumar Khan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Gsα Controls Cortical Bone Quality by Regulating Osteoclast Differentiation via cAMP/PKA and β-Catenin Pathways

(2017) Girish Ramaswamy et al.   Scientific Reports

Transplantation of osteoporotic bone marrow stromal cells rejuvenated by the overexpression of SATB2 prevents alveolar bone loss in ovariectomized rats

(2016) Rongyao Xu et al.   EXPERIMENTAL GERONTOLOGY

Three-Dimensional Printing of Reduction Template in the Contouring of Craniofacial Fibrous Dysplasia

(2016) Ruichen Wang et al.   JOURNAL OF CRANIOFACIAL SURGERY

Activation of PTHrP-cAMP-CREB1 signaling following p53 loss is essential for osteosarcoma initiation and maintenance

(2016) Mannu K Walia et al.   eLife

Dental Follicle Cells Participate in Tooth Eruption via the RUNX2-MiR-31-SATB2 Loop

(2015) J. Ge et al.   JOURNAL OF DENTAL RESEARCH

Selective inhibition of HDAC8 decreases neuroblastoma growth in vitro and in vivo and enhances retinoic acid-mediated differentiation

(2015) I Rettig et al.   Cell Death & Disease

HDAC8, A Potential Therapeutic Target for the Treatment of Malignant Peripheral Nerve Sheath Tumors (MPNST)

(2015) Gonzalo Lopez et al.   PLoS One

Histone deacetylase 8 suppresses osteogenic differentiation of bone marrow stromal cells by inhibiting histone H3K9 acetylation and RUNX2 activity

(2014) Yu Fu et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Constitutive Expression of GsαR201Cin Mice Produces a Heritable, Direct Replica of Human Fibrous Dysplasia Bone Pathology and Demonstrates Its Natural History

(2014) Isabella Saggio et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Direct 3D powder printing of biphasic calcium phosphate scaffolds for substitution of complex bone defects

(2014) Miguel Castilho et al.   Biofabrication

Molecular, Phenotypic Aspects and Therapeutic Horizons of Rare Genetic Bone Disorders

(2014) Taha Faruqi et al.   Biomed Research International

The Up-Regulation of Histone Deacetylase 8 Promotes Proliferation and Inhibits Apoptosis in Hepatocellular Carcinoma

(2013) Jian Wu et al.   DIGESTIVE DISEASES AND SCIENCES

cAMP signalling inhibits p53 acetylation and apoptosis via HDAC and SIRT deacetylases

(2013) MARTINE MÜLLER KLOSTER et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

GNAS mutational analysis in differentiating fibrous dysplasia and ossifying fibroma of the jaw

(2013) Rui-Rui Shi et al.   MODERN PATHOLOGY

Histone Deacetylase Inhibition with Valproic Acid Downregulates Osteocalcin Gene Expression in Human Dental Pulp Stem Cells and Osteoblasts: Evidence for HDAC2 Involvement

(2013) Francesca Paino et al.   STEM CELLS

Dental perspectives in fibrous dysplasia and McCune–Albright syndrome

(2013) Sunday O. Akintoye et al.   Oral Surgery Oral Medicine Oral Pathology Oral Radiology

Different Roles of GNAS and cAMP Signaling During Early and Late Stages of Osteogenic Differentiation

(2012) S. Zhang et al.   HORMONE AND METABOLIC RESEARCH

Denosumab treatment for fibrous dysplasia

(2012) Alison M Boyce et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Histone Deacetylase Inhibitors Stimulate Dedifferentiation of Human Breast Cancer Cells Through WNT/β-Catenin Signaling

(2012) Bisrat G. Debeb et al.   STEM CELLS

Histone Deacetylase Inhibition Mediates Urocortin-Induced Antiproliferation and Neuronal Differentiation in Neural Stem Cells

(2012) Hsin-Yi Huang et al.   STEM CELLS

Skeletal progenitors and the GNAS gene: fibrous dysplasia of bone read through stem cells

(2010) Mara Riminucci et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

Epigenetic control of skull morphogenesis by histone deacetylase 8

(2009) M. Haberland et al.   GENES & DEVELOPMENT

A novel microRNA targeting HDAC5 regulates osteoblast differentiation in mice and contributes to primary osteoporosis in humans

(2009) Hui Li et al.   JOURNAL OF CLINICAL INVESTIGATION

The nature of fibrous dysplasia

(2009) Liviu Feller et al.   Head & Face Medicine

Inactivation of CREB mediated gene transcription by HDAC8 bound protein phosphatase

(2008) Jingxia Gao et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Histone Deacetylase 8 in Neuroblastoma Tumorigenesis

(2008) I. Oehme et al.   CLINICAL CANCER RESEARCH

Bone Morphogenic Protein 2 Activates Protein Kinase D to Regulate Histone Deacetylase 7 Localization and Repression of Runx2

(2008) Eric D. Jensen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A novel histone deacetylase 8 (HDAC8)-specific inhibitor PCI-34051 induces apoptosis in T-cell lymphomas

(2008) S Balasubramanian et al.   LEUKEMIA

Formation of osteoclast-like cells on HA and TCP ceramics

(2007) R. Detsch et al.   Acta Biomaterialia

Regulating gene transcription in response to cyclic AMP elevation

(2007) William A. Sands et al.   CELLULAR SIGNALLING