Non-estrogenic Xanthohumol Derivatives Mitigate Insulin Resistance and Cognitive Impairment in High-Fat Diet-induced Obese Mice

Xanthohumol and 8-prenylnaringenin ameliorate diabetic-related metabolic dysfunctions in mice

(2017) Raquel Costa et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Systemic pan-AMPK activator MK-8722 improves glucose homeostasis but induces cardiac hypertrophy

(2017) Robert W. Myers et al.   SCIENCE

Sodium butyrate attenuates high-fat diet-induced steatohepatitis in mice by improving gut microbiota and gastrointestinal barrier

(2017) Da Zhou et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Xanthohumol ameliorates lipopolysaccharide (LPS)-induced acute lung injury via induction of AMPK/GSK3β-Nrf2 signal axis

(2017) Hongming Lv et al.   Redox Biology

Xanthohumol improves dysfunctional glucose and lipid metabolism in diet-induced obese C57BL/6J mice

(2016) Cristobal L. Miranda et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Conformational modulation of the farnesoid X receptor by prenylflavonoids: Insights from hydrogen deuterium exchange mass spectrometry (HDX-MS), fluorescence titration and molecular docking studies

(2016) Liping Yang et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Long-term Metformin Use and Vitamin B12 Deficiency in the Diabetes Prevention Program Outcomes Study

(2016) Vanita R. Aroda et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

The beneficial potential of polyphenol-enriched fraction from Erigerontis Herba on metabolic syndrome

(2016) Yan Ping Wang et al.   JOURNAL OF ETHNOPHARMACOLOGY

Targeting inflammation in metabolic syndrome

(2016) Francine K. Welty et al.   Translational Research

Hop derived flavonoid xanthohumol inhibits endothelial cell functions via AMPK activation

(2016) Cristina Gallo et al.   Oncotarget

Inside the Diabetic Brain: Role of Different Players Involved in Cognitive Decline

(2015) Joana M. Gaspar et al.   ACS Chemical Neuroscience

Insulin resistance and cognitive dysfunction

(2015) Lina Ma et al.   CLINICA CHIMICA ACTA

Cellular and metabolic alterations in the hippocampus caused by insulin signalling dysfunction and its association with cognitive impairment during aging and Alzheimer's disease: studies in animal models

(2015) Erika Calvo-Ochoa et al.   DIABETES-METABOLISM RESEARCH AND REVIEWS

Activated AMPK boosts the Nrf2/HO-1 signaling axis—A role for the unfolded protein response

(2015) Kristin Zimmermann et al.   FREE RADICAL BIOLOGY AND MEDICINE

Prevalence of the Metabolic Syndrome in the United States, 2003-2012

(2015) Maria Aguilar et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Carnosic Acid as a Major Bioactive Component in Rosemary Extract Ameliorates High-Fat-Diet-Induced Obesity and Metabolic Syndrome in Mice

(2015) Yantao Zhao et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Xanthohumol Improves Diet-induced Obesity and Fatty Liver by Suppressing Sterol Regulatory Element-binding Protein (SREBP) Activation

(2015) Shingo Miyata et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Leptin in autoimmune diseases

(2015) Claudio Procaccini et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

ApoE2 Exaggerates PTSD-Related Behavioral, Cognitive and Neuroendocrine Alterations

(2015) Lance A Johnson et al.   NEUROPSYCHOPHARMACOLOGY

A review of the association between obesity and cognitive function across the lifespan: implications for novel approaches to prevention and treatment

(2015) E. Smith et al.   Obesity Reviews

Xanthohumol improved cognitive flexibility in young mice

(2014) Daniel R. Zamzow et al.   BEHAVIOURAL BRAIN RESEARCH

Risk of Lactic Acidosis or Elevated Lactate Concentrations in Metformin Users With Renal Impairment: A Population-Based Cohort Study

(2014) Willemijn L. Eppenga et al.   DIABETES CARE

Evaluation of the influence of metabolic processes and body composition on cognitive functions: Nutrition and Dementia Project (NutrDem Project)

(2014) R Magierski et al.   EUROPEAN JOURNAL OF CLINICAL NUTRITION

Childhood and adolescent obesity and long-term cognitive consequences during aging

(2014) Jun Wang et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Effects of Xanthohumol-rich Extract from the Hop on Fatty Acid Metabolism in Rats Fed a High-fat Diet

(2014) Kazuki Yui et al.   Journal of Oleo Science

Assessment of the proliferative capacity of the flavanones 8-prenylnaringenin, 6-(1.1-dimethylallyl)naringenin and naringenin in MCF-7 cells and the rat mammary gland

(2014) Janina Helle et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Apolipoprotein E–low density lipoprotein receptor interaction affects spatial memory retention and brain ApoE levels in an isoform-dependent manner

(2014) Lance A. Johnson et al.   NEUROBIOLOGY OF DISEASE

Polyphenol-rich Rutgers Scarlet Lettuce improves glucose metabolism and liver lipid accumulation in diet-induced obese C57BL/6 mice

(2014) Diana M. Cheng et al.   NUTRITION

Anticarcinogenic activity of polyphenolic extracts from grape stems against breast, colon, renal and thyroid cancer cells

(2014) Despina Sahpazidou et al.   TOXICOLOGY LETTERS

Relationships Between Diabetes and Cognitive Impairment

(2013) Suzanne M. de la Monte   ENDOCRINOLOGY AND METABOLISM CLINICS OF NORTH AMERICA

Cytotoxicity and apoptosis induction in human breast adenocarcinoma MCF-7 cells by (+)-cyanidan-3-ol

(2013) Jitender Monga et al.   EXPERIMENTAL AND TOXICOLOGIC PATHOLOGY

A Metabolomics-driven Elucidation of the Anti-obesity Mechanisms of Xanthohumol

(2013) Jay S. Kirkwood et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Human pharmacokinetics of xanthohumol, an antihyperglycemic flavonoid from hops

(2013) LeeCole Legette et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Damaging effects of a high-fat diet to the brain and cognition: A review of proposed mechanisms

(2013) Linnea R. Freeman et al.   NUTRITIONAL NEUROSCIENCE

Impact of Metabolic Syndrome on Cognition and Brain

(2012) Kathy F. Yates et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Diabetes as a risk factor for dementia and mild cognitive impairment: a meta-analysis of longitudinal studies

(2012) G. Cheng et al.   INTERNAL MEDICINE JOURNAL

The effects of a high-energy diet on hippocampal-dependent discrimination performance and blood–brain barrier integrity differ for diet-induced obese and diet-resistant rats

(2012) Terry L. Davidson et al.   PHYSIOLOGY & BEHAVIOR

Xanthohumol lowers body weight and fasting plasma glucose in obese male Zucker fa/fa rats

(2012) LeeCole L. Legette et al.   PHYTOCHEMISTRY

Higher reported saturated fat and refined sugar intake is associated with reduced hippocampal-dependent memory and sensitivity to interoceptive signals.

(2011) Heather M. Francis et al.   BEHAVIORAL NEUROSCIENCE

Pharmacokinetics of xanthohumol and metabolites in rats after oral and intravenous administration

(2011) LeeCole Legette et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Factors Predicting Nongenetic Variability in Body Weight Gain Induced by a High-Fat Diet in Inbred C57BL/6J Mice

(2011) Li-Na Zhang et al.   Obesity

(−)−Epigallocatechin-3-gallate Inhibits Pancreatic Lipase and Reduces Body Weight Gain in High Fat-Fed Obese Mice

(2011) Kimberly A. Grove et al.   Obesity

Bile Acids as Regulators of Hepatic Lipid and Glucose Metabolism

(2010) Michael Trauner et al.   DIGESTIVE DISEASES

The rise and fall of rosiglitazone

(2010) S. E. Nissen   EUROPEAN HEART JOURNAL

Short-term consumption of a high-fat diet impairs whole-body efficiency and cognitive function in sedentary men

(2010) Lindsay M. Edwards et al.   FASEB JOURNAL

Xanthohumol feeding does not impair organ function and homoeostasis in mice

(2010) Christoph Dorn et al.   FOOD AND CHEMICAL TOXICOLOGY

Actions of exendin-4 therapy on cognitive function and hippocampal synaptic plasticity in mice fed a high-fat diet

(2010) V A Gault et al.   INTERNATIONAL JOURNAL OF OBESITY

Insulin resistance is associated with the pathology of Alzheimer disease: The Hisayama Study

(2010) T. Matsuzaki et al.   NEUROLOGY

Deterioration of physical performance and cognitive function in rats with short-term high-fat feeding

(2009) Andrew J. Murray et al.   FASEB JOURNAL

Long-term effects of high lipid and high energy diet on serum lipid, brain fatty acid composition, and memory and learning ability in mice

(2009) Huanling Yu et al.   INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE

The Efficiency of Cellular Energy Transduction and Its Implications for Obesity

(2008) Mary-Ellen Harper et al.   Annual Review of Nutrition

Cognitive Dysfunction and Diabetes Mellitus

(2008) Christopher T. Kodl et al.   ENDOCRINE REVIEWS

Activation of the farnesoid X receptor represses PCSK9 expression in human hepatocytes

(2008) Cédric Langhi et al.   FEBS LETTERS

Diet-induced insulin resistance impairs hippocampal synaptic plasticity and cognition in middle-aged rats

(2008) Alexis M. Stranahan et al.   HIPPOCAMPUS

Role of AMP-Activated Protein Kinase in the Control of Appetite

(2008) B. Kola   JOURNAL OF NEUROENDOCRINOLOGY

Complementary and Alternative Medicine and the Management of the Metabolic Syndrome

(2008) Jason M. Hollander et al.   JOURNAL OF THE AMERICAN DIETETIC ASSOCIATION

Selection of cytotoxicity markers for the screening of new chemical entities in a pharmaceutical context: A preliminary study using a multiplexing approach

(2008) H.H.J. Gerets et al.   TOXICOLOGY IN VITRO