Article
Biochemistry & Molecular Biology
Javier Quero, Nerea Jimenez-Moreno, Irene Esparza, Jesus Osada, Elena Cerrada, Carmen Ancin-Azpilicueta, Maria Jesus Rodriguez-Yoldi
Summary: Grape stem extracts rich in polyphenols have antiproliferative effects on cancer cells through apoptosis cell death and modulation of ROS levels. Additionally, these extracts exhibit antioxidant effects on intestinal cells, offering potential protection against diseases related to oxidative stress. The bioactive compounds in grape extracts could be utilized as bio-functional food ingredients for disease prevention and improving human health.
Article
Food Science & Technology
Daniel J. Garcia-Martinez, Maria Arroyo-Hernandez, Maria Posada-Ayala, Cruz Santos
Summary: Research shows that the concentration process of grape juice negatively affects the stability of polyphenols, resulting in a reduction in polyphenol content ranging from 54% to 71%, except for quercetin and catechin.
Article
Food Science & Technology
Matteo Perra, Gianluigi Bacchetta, Aldo Muntoni, Giorgia De Gioannis, Ines Castangia, Hiba N. Rajha, Maria Letizia Manca, Maria Manconi
Summary: This review provides an outlook on the resources and products that can be obtained through the recovery of grape pomace, along with the analysis of chemical, physical, and biotechnological processes. Special attention is given to the manufacturing of high-value compounds and products, such as supplements, nutraceuticals, and cosmeceuticals. The review also updates the composition of grape pomace and analyzes its traditional fate, as well as discusses modern and green sustainable management approaches.
JOURNAL OF FUNCTIONAL FOODS
(2022)
Article
Food Science & Technology
Ehsan Ranjbaran, Mansour Gholami, Martin Jensen
Summary: The influence of methyl jasmonate (MJ) preharvest treatment on polyphenols and antioxidant systems in Thompson Seedless table grape was investigated. High concentrations of MJ treatment increased the antioxidant activity and enzyme activity, and also influenced the levels of certain polyphenolic compounds in the grape.
FOOD SCIENCE & NUTRITION
(2022)
Article
Biochemistry & Molecular Biology
Paola Angelini, Giancarlo Angeles Flores, Alessandro Piccirilli, Roberto Venanzoni, Alessandra Acquaviva, Simonetta Cristina Di Simone, Maria Loreta Libero, Bruno Tirillini, Gokhan Zengin, Annalisa Chiavaroli, Lucia Recinella, Sheila Leone, Luigi Brunetti, Giustino Orlando, Luigi Menghini, Claudio Ferrante
Summary: This study compares the phenolic composition and biological activities of grape pomace and juice, and finds that different grape varieties have different antioxidant and antifungal effects. Multiple antifungal mechanisms are suggested, which opens up new potential applications for grape byproducts.
PROCESS BIOCHEMISTRY
(2022)
Article
Plant Sciences
Natalia Langa-Lomba, Eva Sanchez-Hernandez, Laura Buzon-Duran, Vicente Gonzalez-Garcia, Jose Casanova-Gascon, Jesus Martin-Gil, Pablo Martin-Ramos
Summary: The chemical composition of Rubia tinctorum root extract was analyzed, revealing over 50 constituents with alizarin-related anthraquinones and phenol compounds as the main phytochemicals. The extract showed strong antifungal activity, which was further enhanced when combined with chitosan oligomers or stevioside. This natural antifungal compound presents a promising alternative for sustainable control methods against grapevine trunk diseases.
Article
Biochemistry & Molecular Biology
Annalisa Chiavaroli, Marwa Balaha, Alessandra Acquaviva, Claudio Ferrante, Amelia Cataldi, Luigi Menghini, Monica Rapino, Giustino Orlando, Luigi Brunetti, Sheila Leone, Lucia Recinella, Viviana di Giacomo
Summary: The study found that grape pomace extract and catechin can reverse oxidative stress-induced cytotoxicity, increase dopamine release, prevent the downregulation of brain-derived neurotrophic factor (BDNF), and upregulate cyclooxygenase-2 (COX-2) gene expression. This suggests that the neuroprotection induced by the extract could be partially attributed to its catechin content.
Article
Biology
Roberta Barreto de Andrade, Bruna Aparecida Souza Machado, Gabriele de Abreu Barreto, Renata Quartieri Nascimento, Luiz Claudio Correa, Ingrid Lessa Leal, Pedro Paulo Lordelo Guimaraes Tavares, Ederlan de Souza Ferreira, Marcelo Andres Umsza-Guez
Summary: This study investigated the influence of different extraction parameters on bioactive compounds from Syrah grape skin, finding that sonication for 20 minutes yielded the best results, while a temperature of 60 degrees C had significant effects on various compounds. However, the combination of this temperature with ultrasound showed lower extraction efficiency for certain compounds. The study concluded that further analysis is needed on the use of ultrasound for extracting bioactive compounds from grape skin residue, which has potential as a source of antioxidants and antimicrobial compounds.
Article
Biochemistry & Molecular Biology
Giovanna Baron, Giulio Ferrario, Cristina Marinello, Marina Carini, Paolo Morazzoni, Giancarlo Aldini
Summary: A detailed LC-MS analysis of red grape skin extracted with ethanol and water mixture identified various beneficial compounds. While the EtOH:H2O solvent was found to be the most efficient for overall polyphenol extraction, water extraction under heating conditions showed effectiveness for certain polyphenolic classes in terms of yield and anti-inflammatory activity.
Article
Food Science & Technology
Giorgia Musto, Elisabetta Schiano, Fortuna Iannuzzo, Gian Carlo Tenore, Ettore Novellino, Mariano Stornaiuolo
Summary: Agri-food by-products contribute to pollution when disposed incorrectly, but can be recycled as alternative raw material for bioactive compound extraction. Safety assessment is crucial due to chemical complexity. In this study, two nutraceutical products obtained from food waste were evaluated for mutagenicity using the Ames and micronucleus test. Results show that the products are genotoxically safe up to specific doses, complying with safety regulations.
Article
Plant Sciences
Guillermo F. Padilla-Gonzalez, Esther Grosskopf, Nicholas J. Sadgrove, Monique S. J. Simmonds
Summary: Grape seeds are rich in flavan-3-ol compounds, especially B-type procyanidins and monomers such as catechin and epicatechin. This review provides an overview of the existing literature on grape seed chemistry, exploring the variations in chemistry, signs of adulteration, and factors influencing metabolite expression. The research suggests that the expression of these compounds is primarily influenced by genotype and environment.
Article
Plant Sciences
Suwen Lu, Yaxian Zhuge, Tianyi Hao, Zhongjie Liu, Mengwei Zhang, Jinggui Fang
Summary: In this study, 47 OMT members were identified in the grape genome and their characteristics, distribution, expression, and regulation were investigated. The results showed that some OMT members are involved in the synthesis of methylated flavonoids and play important roles in the growth and defense of grapes.
PLANT PHYSIOLOGY AND BIOCHEMISTRY
(2022)
Review
Food Science & Technology
Nawel Benbouguerra, Ruth Hornedo-Ortega, Francois Garcia, Toni El Khawand, Cedric Saucier, Tristan Richard
Summary: Stilbenes are natural phenolic compounds synthesized by plants in response to stress. They are found in grape berries and wine, with potential anti-obesity effects. Optimized analytical methods are essential for accurate detection and quantification of stilbenes.
TRENDS IN FOOD SCIENCE & TECHNOLOGY
(2021)
Article
Agronomy
Zhilei Wang, Ying Wang, Dong Wu, Miao Hui, Xing Han, Tingting Xue, Fei Yao, Feifei Gao, Xiao Cao, Hua Li, Hua Wang
Summary: This study evaluated cold resistance of 124 wine grape germplasms by determining their low-temperature half-lethal temperature (LT50) values, clustering them into different types based on cold resistance levels and exploring cold regionalization for wine grape cultivation in China. Strong cold-resistant V. vinifera germplasms were identified for potential breeding, and the results suggested the possibility of cultivating wine grapes without winter burial overwintering in some areas of China.
Article
Biology
Xiangru Chen, Fang Yang, Chunwei Bai, Qianrui Shi, Shan Hu, Xianying Tang, Lijuan Peng, Haixia Ding
Summary: This study confirms that Bacillus velezensis strain GUMT319 is a plant growth-promoting rhizobacteria that increases grape yield. By analyzing soil properties and microbial composition, it was found that GUMT319 altered the physical and chemical properties and microbial community composition of the soil. The results suggest that GUMT319 acts as both a biocontrol agent and a plant growth-promoting rhizobacteria, improving grape yield by modifying the soil environment.
Article
Medicine, General & Internal
Ismail Topal, Mustafa Yasar Ozdamar, Tulin Catakli, Ismail Malkoc, Ahmet Hacimuftuoglu, Charalampos Mamoulakis, Aristidis Tsatsakis, Konstantinos Tsarouhas, Christina Tsitsimpikou, Ali Taghizadehghalehjoughi
Summary: This study aimed to evaluate the renoprotective effects of taxifolin (TXF) in a paracetamol (PAR)-induced nephrotoxicity rat model. The results showed that the levels of blood urea nitrogen, creatinine and malondialdehyde were significantly increased in the PAR group, while the levels of glutathione peroxidase, glutathione reductase and total glutathione were significantly higher in the TXF group. Histopathological examination revealed severe tubular epithelium damage in the PAR group, while the TXF group showed mild dilated/congested blood vessels. These findings suggest that TXF has potential renoprotective effects against PAR-induced nephrotoxicity through its antioxidant activity and should be further investigated.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Pharmacology & Pharmacy
Sidika Genc, Ali Taghizadehghalehjoughi, Yesim Yeni, Abbas Jafarizad, Ahmet Hacimuftuoglu, Dragana Nikitovic, Anca Oana Docea, Yaroslav Mezhuev, Aristidis Tsatsakis
Summary: In this study, the combination of Fe3O4 NPs and 5-FU showed a synergistic cytotoxic effect on Caco-2 cells at concentrations below the active drug threshold levels.
Article
Biochemistry & Molecular Biology
Maria Kourti, Maria V. V. Alvanou, Zoi Skaperda, Fotis Tekos, Georgios Papaefstathiou, Panagiotis Stathopoulos, Demetrios Kouretas
Summary: An extract from brine samples obtained through the Greek style debittering process of Kalamon olive fruits showed strong antioxidant capacity and DNA-protective activity. The extract consisted mainly of hydroxytyrosol, verbascoside, and tyrosol. In cell-free assays, the extract demonstrated radical scavenging ability, while in cell cultures, it exhibited cell type specific responses and protected against H2O2-induced DNA damage. Overall, this study highlights the potential of table olive wastewaters as a valuable source of bioactive compounds for various industries.
Review
Medicine, Research & Experimental
Michael Aschner, Anatoly V. Skalny, Viktor A. Gritsenko, Olga L. Kartashova, Abel Santamaria, Joao B. T. Rocha, Demetrios A. Spandidos, Irina P. Zaitseva, Aristidis Tsatsakis, Alexey A. Tinkov
Summary: The aim of this study was to summarize the potential interactive effects between the gut microbiota and advanced glycation end-product (AGE) accumulation and toxicity in the host, and to reveal the mediating effects of the gut microbiota on AGE-related health effects. Existing data demonstrates that dietary AGEs can significantly impact the richness and diversity of the gut microbiota, with specific effects depending on species type and exposure dose. Additionally, the gut microbiota may metabolize dietary AGEs. The characteristics of the gut microbiota, including richness and relative abundance of certain taxa, are closely associated with AGE accumulation in the host organism. In turn, the interplay between AGE toxicity and modulation of the gut microbiota may contribute to aging and diabetes-associated diseases. Bacterial endotoxin lipopolysaccharide appears to mediate the interactions between the gut microbiota and AGE toxicity, specifically through modulation of the receptor for AGE signaling. Therefore, modulation of the gut microbiota using probiotics or other dietary interventions may significantly impact AGE-induced glycative stress and systemic inflammation.
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Vasiliki Karzi, Eren Ozcagli, Manolis N. Tzatzarakis, Elena Vakonaki, Irene Fragkiadoulaki, Aikaterini Kalliantasi, Christina Chalkiadaki, Athanasios Alegakis, Polychronis Stivaktakis, Aikaterini Karzi, Antonios Makrigiannakis, Anca Oana Docea, Daniela Calina, Aristidis Tsatsakis
Summary: Exposure to combined endocrine disruptors can cause DNA damage, as observed in this study using comet and micronuclei assays. The highest level of damage was found in the group exposed to a high-dose mixture of substances, particularly glyphosate. The micronuclei assay results were moderately correlated with exposure period, and all exposure groups showed an increasing trend in micronuclei counts over time.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Oncology
Aristidis Tsatsakis, Tatiana Oikonomopoulou, Taxiarchis Konstantinos Nikolouzakis, Elena Vakonaki, Manolis Tzatzarakis, Matthaios Flamourakis, Elisavet Renieri, Persefoni Fragkiadaki, Evaggelia Iliaki, Maria Bachlitzanaki, Vasiliki Karzi, Ioanna Katsikantami, Fotios Kakridonis, Eleftheria Hatzidaki, Maria Tolia, Andrey A. Svistunov, Demetrios A. Spandidos, Dragana Nikitovic, John Tsiaoussis, Aikaterini Berdiaki
Summary: Cancer is a major issue in clinical, social, and economic aspects, ranking highest in terms of cause-specific disability-adjusted life years among all human pathologies. The trigger of cancer involves various factors, including genetic predisposition and telomere status, which are DNA structures at the end of chromosomes. However, there is no universal trend in the association between telomere length and cancer, as both short and long telomeres have been linked to high cancer incidence risks. This review aims to present the complex relationship between telomere length and cancer comprehensively.
INTERNATIONAL JOURNAL OF ONCOLOGY
(2023)
Review
Toxicology
Yuliya V. Ryabova, Marina P. Sutunkova, Ilzira A. Minigalieva, Lada V. Shabardina, Tommaso Filippini, Aristides Tsatsakis
Summary: This paper provides a comprehensive summary of the toxicological studies conducted on selenium nanoparticles (NPs) using laboratory animals. In vivo studies have shown adverse effects of selenium NPs on laboratory animals, including reductions in body mass, changes in hepatotoxicity indices, and possible impairment of metabolic processes. However, no specific toxic action solely attributable to selenium has been identified. The LOAEL and NOAEL values are contradictory, and the relationship between the adverse effects of selenium NPs and exposure dose is controversial and diverse.
JOURNAL OF APPLIED TOXICOLOGY
(2023)
Article
Oncology
Ozgur Celebi, Ali Taghizadehghalehjoughi, Demet Celebi, Robin Mesnage, Kirill Sergeevich Golokhvast, Andreea Letitia Arsene, Demetrios A. Spandidos, Aristidis Tsatsakis
Summary: The gut microbiota is important for maintaining health and regulating immune response. Probiotics and vitamins can improve microbial population and prevent tight junction protein breakdown. The study evaluated the effects of vitamins and probiotics on Escherichia coli and Staphylococcus aureus.
MOLECULAR MEDICINE REPORTS
(2023)
Article
Biochemistry & Molecular Biology
Fotios Tekos, Zoi Skaperda, Periklis Vardakas, Despina Kyriazi, Georgios C. C. Maravelis, Konstantinos Poulas, Ioannis A. A. Taitzoglou, Charitini Nepka, Demetrios Kouretas
Summary: Wine and its by-products, such as grape stems, contain bioactive polyphenolic compounds that can potentially benefit animal and human health. However, there are limited studies on the safety and toxicological risks of these compounds in vivo. This study examined the effects of oral administration of grape stem and wine extracts on redox biomarkers in mice and rats. The results showed that grape stem extract improved redox homeostasis in mice, while wine extract had both beneficial and harmful effects on rat redox status, indicating the complexity of biological systems.
Article
Biochemistry & Molecular Biology
Emmanouil Karampinis, Athina-Maria Aloizou, Efterpi Zafiriou, Alexandra Bargiota, Zoi Skaperda, Demetrios Kouretas, Angeliki-Viktoria Roussaki-Schulze
Summary: UV radiation has both harmful and beneficial effects on skin health. It can cause oxidative stress, leading to skin cancer and photoaging. However, it is also necessary for the production of vitamin D, which has important antioxidant and anticancer properties. This study found that skin cancer patients have lower levels of vitamin D and increased oxidative stress.
Article
Environmental Sciences
Cigdem Sevim, Erol Akpinar, Emrah Hicazi Aksu, Ali Dogan Omur, Serkan Yildirim, Mehtap Kara, Ismail Bolat, Aristides Tsatsakis, Robin Mesnage, Kirill S. S. Golokhvast, Sevgi Karabulut Uzuncakmak, Rabia Nilufer Ersoylu
Summary: The study aimed to investigate the positive effects of probiotic Saccharomyces boulardii on the male reproductive system under low dose neonicotinoid pesticide exposure conditions. Acetamiprid and imidacloprid caused degeneration and necrosis of spermatocytes, severe edema of the intertubular region, and hyperemia. This was accompanied by increased oxidative stress and apoptosis. Saccharomyces boulardii supplementation mitigated these toxic effects.
Editorial Material
Substance Abuse
Cornel Radu-Loghin, Karina Mocanu, Hani Al Gouhmani, Constantine Vardavas, Ioanna Lagou, Zinovia Plyta, Aikaterini Papathanasaki, Stella Vogiatzidaki, Alexander Vardavas, Manolis Tzatzarakis, Aristidis Tsatsakis, Filip-pos Filippidis, Christina Kyriakos, Esteve Fernandez, Olena Tigova, Cristina Martinez, Anna Mar Lopez Luque, Marius Eremia, Lucia Maria Lotrean, Antigona Trofor, Thomas Wenzl, Bill Simpson, Pippa Powell, Polina Starchenko, Angeliki Bakou, Eleni Asimaki, Victoria Vivilaki
TOBACCO PREVENTION & CESSATION
(2023)
Article
Oncology
Aristidis Tsatsakis, Elisavet Renieri, Dimitris Tsoukalas, Ana Maria Buga, Evangelia Sarandi, Elena Vakonaki, Persefoni Fragkiadaki, Athanasios Alegakis, Dragana Nikitovic, Daniela Calina, Demetrios A. Spandidos, Anca Oana Docea
Summary: This study evaluated the effects of a novel telomerase activator on telomere length and telomerase activity in aged rats. The nutraceutical formulation was found to reduce telomere shortening rate at lower dose and increase telomere length at higher dose. Telomerase activity was also increased in the treated rats.
MOLECULAR MEDICINE REPORTS
(2023)
Article
Environmental Sciences
Yuliya V. Ryabova, Ilzira A. Minigalieva, Marina P. Sutunkova, Svetlana V. Klinova, Alexandra K. Tsaplina, Irene E. Valamina, Ekaterina M. Petrunina, Aristides M. Tsatsakis, Charalampos Mamoulakis, Kostas Stylianou, Sergey V. Kuzmin, Larisa I. Privalova, Boris A. Katsnelson
Summary: This study found that chronic diseases of the urogenital tract can develop under the effects of chemical hazards in the working environment, particularly from nanosized particles generated in industrial processes. The researchers studied the nephrotoxicity of element oxide nanoparticles through animal experiments, and found that these nanoparticles had a toxic effect on the kidneys and caused changes in kidney function and histological structure. The results of this study are important for the early diagnosis of occupational and nonoccupational nephropathies.
Review
Medicine, Research & Experimental
Fotios Kakridonis, Spyros G. Pneumatikos, Elena Vakonaki, Aikaterini Berdiaki, Manolis N. Tzatzarakis, Persefoni Fragkiadaki, Demetrios A. Spandidos, Stella Baliou, Petros Ioannou, Eleftheria Hatzidaki, Dragana Nikitovic, Aristidis Tsatsakis, Elias Vasiliadis
Summary: This review summarizes the potential of telomere shortening as a biomarker for detecting the onset of osteoporosis. It found a weak association between telomere length and osteoporosis in some studies, suggesting that telomere shortening may be used as a biomarker for tracking the development and progression of osteoporosis.
BIOMEDICAL REPORTS
(2023)
