β-Sitosterol targets Trx/Trx1 reductase to induce apoptosis in A549 cells via ROS mediated mitochondrial dysregulation and p53 activation
出版年份 2018 全文链接
标题
β-Sitosterol targets Trx/Trx1 reductase to induce apoptosis in A549 cells via ROS mediated mitochondrial dysregulation and p53 activation
作者
关键词
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出版物
Scientific Reports
Volume 8, Issue 1, Pages -
出版商
Springer Nature
发表日期
2018-01-26
DOI
10.1038/s41598-018-20311-6
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注意:仅列出部分参考文献,下载原文获取全部文献信息。- Beta sitosterol and Daucosterol (phytosterols identified in Grewia tiliaefolia) perturbs cell cycle and induces apoptotic cell death in A549 cells
- (2017) Tamilselvam Rajavel et al. Scientific Reports
- Cancer statistics, 2016
- (2016) Rebecca L. Siegel et al. CA-A CANCER JOURNAL FOR CLINICIANS
- Potential of apoptotic pathway-targeted cancer therapeutic research: Where do we stand?
- (2016) S Baig et al. Cell Death & Disease
- Cell death mechanisms of plant-derived anticancer drugs: beyond apoptosis
- (2015) Hala Gali-Muhtasib et al. APOPTOSIS
- Role of Phytosterols in Cancer Prevention and Treatment
- (2015) Vanu Ramkumar Ramprasath et al. JOURNAL OF AOAC INTERNATIONAL
- Beta-Sitosterol: A Promising but Orphan Nutraceutical to Fight Against Cancer
- (2015) Muhammad Shahdaat Bin Sayeed et al. NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL
- Targeting Oncogenic Mutant p53 for Cancer Therapy
- (2015) Alejandro Parrales et al. Frontiers in Oncology
- Assessment of dual inhibition property of newly discovered inhibitors against PCAF and GCN5 throughin silicoscreening, molecular dynamics simulation and DFT approach
- (2014) Venkatesan Suryanarayanan et al. JOURNAL OF RECEPTORS AND SIGNAL TRANSDUCTION
- Insights into the structural basis of 3,5-diaminoindazoles as CDK2 inhibitors: prediction of binding modes and potency by QM–MM interaction, MESP and MD simulation
- (2014) Sunil Kumar Tripathi et al. Molecular BioSystems
- Mitochondrial Reactive Oxygen Species (ROS) and ROS-Induced ROS Release
- (2014) Dmitry B. Zorov et al. PHYSIOLOGICAL REVIEWS
- Physics-based enzyme design: Predicting binding affinity and catalytic activity
- (2014) Sarah Sirin et al. PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS
- Modulation of oxidative stress as an anticancer strategy
- (2013) Chiara Gorrini et al. NATURE REVIEWS DRUG DISCOVERY
- Caspase Functions in Cell Death and Disease
- (2013) D. R. McIlwain et al. Cold Spring Harbor Perspectives in Biology
- Non-Small Cell Lung Cancer: Epidemiology, Risk Factors, Treatment, and Survivorship
- (2012) Julian R. Molina et al. MAYO CLINIC PROCEEDINGS
- p53 mutations in cancer
- (2012) Patricia A. J. Muller et al. NATURE CELL BIOLOGY
- Recent advances in apoptosis, mitochondria and drug resistance in cancer cells
- (2011) Inthrani R. Indran et al. BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS
- Mitochondria in Apoptosis: Bcl-2 Family Members and Mitochondrial Dynamics
- (2011) Jean-Claude Martinou et al. DEVELOPMENTAL CELL
- Apoptosis in cancer: from pathogenesis to treatment
- (2011) Rebecca SY Wong JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
- The VSGB 2.0 model: A next generation energy model for high resolution protein structure modeling
- (2011) Jianing Li et al. PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS
- Modulation of signal transduction in cancer cells by phytosterols
- (2010) Peter G. Bradford et al. BIOFACTORS
- Chemopreventive potential of β-Sitosterol in experimental colon cancer model - an In vitro and In vivo study
- (2010) Albert A Baskar et al. BMC Complementary and Alternative Medicine
- Probing theα-Helical Structural Stability of Stapled p53 Peptides: Molecular Dynamics Simulations and Analysis
- (2010) Zuojun Guo et al. Chemical Biology & Drug Design
- Thioredoxin and Cancer: A Role for Thioredoxin in all States of Tumor Oxygenation
- (2010) Therese Christina Karlenius et al. Cancers
- Anticancer effects of phytosterols
- (2009) T A Woyengo et al. EUROPEAN JOURNAL OF CLINICAL NUTRITION
- β-Sitosterol Inhibits Cell Growth and Induces Apoptosis in SGC-7901 Human Stomach Cancer Cells
- (2009) Yonghuan Zhao et al. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
- Cell protection induced by beta-sitosterol: inhibition of genotoxic damage, stimulation of lymphocyte production, and determination of its antioxidant capacity
- (2008) R. Paniagua-Pérez et al. ARCHIVES OF TOXICOLOGY
- β-Sitosterol induces G2/M arrest, endoreduplication, and apoptosis through the Bcl-2 and PI3K/Akt signaling pathways
- (2008) Dong-Oh Moon et al. CANCER LETTERS
- ROS and p53: A versatile partnership
- (2008) Bin Liu et al. FREE RADICAL BIOLOGY AND MEDICINE
- Tumor resistance to apoptosis
- (2008) Simone Fulda INTERNATIONAL JOURNAL OF CANCER
- Caspases in apoptosis and beyond
- (2008) J Li et al. ONCOGENE
- Plant-derived compounds in clinical trials
- (2007) A SAKLANI et al. DRUG DISCOVERY TODAY
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