Current knowledge and development of hederagenin as a promising medicinal agent: a comprehensive review

Design, synthesis and biological evaluation of novel α-hederagenin derivatives with anticancer activity

(2017) Xian-xuan Liu et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Leishmanicidal and cytotoxic activity of hederagenin-bistriazolyl derivatives

(2017) Diego Rodríguez-Hernández et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Hederagenin and α-hederin promote degradation of proteins in neurodegenerative diseases and improve motor deficits in MPTP-mice

(2017) An-Guo Wu et al.   PHARMACOLOGICAL RESEARCH

Hederagenin Supplementation Alleviates the Pro-Inflammatory and Apoptotic Response to Alcohol in Rats

(2017) Gyeong-Ji Kim et al.   Nutrients

Development and validation of a quantification method for oleanolic acid and hederagenin in rat plasma: application to the pharmacokinetic study

(2016) Heng Zhang et al.   BIOMEDICAL CHROMATOGRAPHY

Highly potent anti-leishmanial derivatives of hederagenin, a triperpenoid from Sapindus saponaria L.

(2016) Diego Rodríguez-Hernández et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Novel hederagenin–triazolyl derivatives as potential anti-cancer agents

(2016) Diego Rodríguez-Hernández et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Assessment of the nutritional composition of quinoa (Chenopodium quinoa Willd.)

(2016) Verena Nowak et al.   FOOD CHEMISTRY

Structure and hemolytic activity relationships of triterpenoid saponins and sapogenins

(2016) Nhu Ngoc Quynh Vo et al.   Journal of Natural Medicines

Hederagenin as a triterpene template for the development of new antitumor compounds

(2015) Diego Rodríguez-Hernández et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Characterisation of phenolics, betanins and antioxidant activities in seeds of three Chenopodium quinoa Willd. genotypes

(2015) Yao Tang et al.   FOOD CHEMISTRY

Hederagenin, a major component of Clematis mandshurica Ruprecht root, attenuates inflammatory responses in RAW 264.7 cells and in mice

(2015) Chul Won Lee et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Identification of novel autophagic Radix Polygalae fraction by cell membrane chromatography and UHPLC-(Q)TOF-MS for degradation of neurodegenerative disease proteins

(2015) An-Guo Wu et al.   Scientific Reports

Hederagenin from the leaves of ivy (Hedera helix L.) induces apoptosis in human LoVo colon cells through the mitochondrial pathway

(2014) Bao-Xin-Zi Liu et al.   BMC Complementary and Alternative Medicine

Determination of asperosaponin VI and its active metabolite hederagenin in rat tissues by LC–MS/MS: Application to a tissue distribution study

(2014) Run Zhang et al.   JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES

Pharmacokinetics study of asperosaponin VI and its metabolites cauloside A, HN saponin F and hederagenin

(2014) Er-Wei Liu et al.   Journal of Natural Medicines

Involvement of norepinephrine and serotonin system in antidepressant-like effects of hederagenin in the rat model of unpredictable chronic mild stress-induced depression

(2014) Bao-Fang Liang et al.   PHARMACEUTICAL BIOLOGY

Towards cytotoxic and selective derivatives of maslinic acid

(2013) Bianka Siewert et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Immunoadjuvant Activity, Toxicity Assays, and Determination by UPLC/Q-TOF-MS of Triterpenic Saponins from Chenopodium quinoa Seeds

(2012) Simone G. Verza et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Phenolic Compounds and Saponins in Quinoa Samples (Chenopodium quinoa Willd.) Grown under Different Saline and Nonsaline Irrigation Regimens

(2012) Ana María Gómez-Caravaca et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Quantitative determination of hederagenin in rat plasma and cerebrospinal fluid by ultra fast liquid chromatography–tandem mass spectrometry method

(2011) Xuemei Yang et al.   JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES

Simultaneous determination of asperosaponin VI and its active metabolite hederagenin in rat plasma by liquid chromatography–tandem mass spectrometry with positive/negative ion-switching electrospray ionization and its application in pharmacokinetic study

(2011) He Zhu et al.   JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES

The extracts of Fructus Akebiae, a preparation containing 90% of the active ingredient hederagenin: Serotonin, norepinephrine and dopamine reuptake inhibitor

(2011) Zeng-Liang Jin et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

The hederagenin saponin SMG-1 is a natural FMLP receptor inhibitor that suppresses human neutrophil activation

(2010) Tsong-Long Hwang et al.   BIOCHEMICAL PHARMACOLOGY

Synthesis of an antitumor active endoperoxide from 11-keto-β-boswellic acid

(2010) René Csuk et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

α-Hederin, but Not Hederacoside C and Hederagenin fromHedera helix, Affects the Binding Behavior, Dynamics, and Regulation of β2-Adrenergic Receptors†

(2009) Anne Sieben et al.   BIOCHEMISTRY

Haemolytic activity, cytotoxicity and membrane cell permeabilization of semi-synthetic and natural lupane- and oleanane-type saponins

(2009) Charles Gauthier et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Macranthoside B, a hederagenin saponin extracted from Lonicera macranthoides and its anti-tumor activities in vitro and in vivo

(2009) Jia Wang et al.   FOOD AND CHEMICAL TOXICOLOGY

Antidepressant effect of the extracts from Fructus Akebiae

(2009) Dan Zhou et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Drug Discovery and Natural Products: End of an Era or an Endless Frontier?

(2009) J. W.-H. Li et al.   SCIENCE

New Pentacyclic Triterpenes fromGypsophila oldhamiana and Their Biological Evaluation as Glycogen Phosphorylase Inhibitors

(2008) Jian-Guang Luo et al.   CHEMISTRY & BIODIVERSITY

Triterpene saponins from Chenopodium quinoa Willd.

(2008) Tiwatt Kuljanabhagavad et al.   PHYTOCHEMISTRY