Discovery and preliminary SAR of 14-aryloxy-andrographolide derivatives as antibacterial agents with immunosuppressant activity

One-pot three steps cascade synthesis of novel isoandrographolide analogues and their cytotoxic activity

(2017) Teerapich Kasemsuk et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Multi-Targeting Andrographolide, a Novel NF-κB Inhibitor, as a Potential Therapeutic Agent for Stroke

(2017) Chih-Hao Yang et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Expression Patterns of TNFα, MAdCAM1, and STAT3 in Intestinal and Skin Manifestations of Inflammatory Bowel Disease

(2017) Stephan R Vavricka et al.   Journal of Crohns & Colitis

Andrographolide, a New Hope in the Prevention and Treatment of Metabolic Syndrome

(2017) Muhammad T. Islam   Frontiers in Pharmacology

Attenuation of Innate Immunity by Andrographolide Derivatives Through NF-κB Signaling Pathway

(2017) Xin Nie et al.   Scientific Reports

Broad-spectrum antiviral properties of andrographolide

(2016) Swati Gupta et al.   ARCHIVES OF VIROLOGY

Inflammatory bowel disease

(2016) Richard Hodson   NATURE

Andrographolide derivative AL-1 improves insulin resistance through down-regulation of NF-κB signalling pathway

(2015) Yongmei Li et al.   BRITISH JOURNAL OF PHARMACOLOGY

Anti-inflammatory effect of procyanidin B1 on LPS-treated THP1 cells via interaction with the TLR4–MD-2 heterodimer and p38 MAPK and NF-κB signaling

(2015) Jing Xing et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Andrographolide inhibits multiple myeloma cells by inhibiting the TLR4/NF-κB signaling pathway

(2015) HUI GAO et al.   Molecular Medicine Reports

Epidemiology and risk factors for IBD

(2015) Ashwin N. Ananthakrishnan   Nature Reviews Gastroenterology & Hepatology

SAR studies of 3,14,19-derivatives of andrographolide on anti-proliferative activity to cancer cells and toxicity to zebrafish: an in vitro and in vivo study

(2015) Yuran Peng et al.   RSC Advances

Andrographolide: progression in its modifications and applications – a patent review (2012 – 2014)

(2014) Chantana Aromdee   EXPERT OPINION ON THERAPEUTIC PATENTS

Review article: the role of oxidative stress in pathogenesis and treatment of inflammatory bowel diseases

(2014) Aleksandra Piechota-Polanczyk et al.   NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

Synthesis and discovery of andrographolide derivatives as non-steroidal farnesoid X receptor (FXR) antagonists

(2014) Zhuyun Liu et al.   RSC Advances

The TLR4 antagonist Eritoran protects mice from lethal influenza infection

(2013) Kari Ann Shirey et al.   NATURE

Chemical and cytokine features of innate immunity characterize serum and tissue profiles in inflammatory bowel disease

(2013) C. G. Knutson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Crohn’s disease complicated by intestinal infection with methicillin-resistantStaphylococcus aureus

(2013) Dominik Bettenworth   WORLD JOURNAL OF GASTROENTEROLOGY

Modifications of andrographolide to increase some biological activities: a patent review (2006 – 2011)

(2012) Chantana Aromdee   EXPERT OPINION ON THERAPEUTIC PATENTS

Prevalence and predictors of MRSA, ESBL, and VRE colonization in the ambulatory IBD population

(2012) Wesley Leung et al.   Journal of Crohns & Colitis

Host–microbe interactions have shaped the genetic architecture of inflammatory bowel disease

(2012) Luke Jostins et al.   NATURE

Cryptopleurine Analogs with Modification of E Ring Exhibit Different Mechanism to Rac-Cryptopleurine and Tylophorine

(2012) Ying Wang et al.   PLoS One

In vitro modulation of LPS/calcimycin induced inflammatory and allergic mediators by pure compounds of Andrographis paniculata (King of bitters) extract

(2010) C.V. Chandrasekaran et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Sur le principe amer de l'Andrographis paniculata N

(2010) K. Gorter   RECUEIL DES TRAVAUX CHIMIQUES DES PAYS-BAS ET DE LA BELGIQUE

Inflammatory Bowel Disease

(2009) Clara Abraham et al.   NEW ENGLAND JOURNAL OF MEDICINE

Synthesis and evaluation of antibacterial activities of andrographolide analogues

(2008) Xiaojian Jiang et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Activation of an IL-6:STAT3-dependent transcriptome in pediatric-onset inflammatory bowel disease

(2007) Rebecca Carey et al.   INFLAMMATORY BOWEL DISEASES