Article
Chemistry, Multidisciplinary
Wei-Wei Fan, Tian Xu, Jia Gao, Han-Yu Zhang, Yan Li, Duo-Duo Hu, Shuaixin Gao, Jia-Hai Zhang, Xing Liu, Dan Liu, Pi-Long Li, Catherine C. L. Wong, Xue-Biao Yao, Yun-Yu Shi, Zhen-Ye Yang, Xi-Sheng Wang, Ke Ruan
Summary: A bivalent inhibitor was discovered to block the multivalent interactions among stress granules and inhibit their growth in cells.
CHEMICAL COMMUNICATIONS
(2023)
Article
Cell Biology
Qianzhi Chen, Qingyi Hu, Yan Chen, Na Shen, Ning Zhang, Anshu Li, Lei Li, Junjun Li
Summary: This study highlights the crucial role of PRMT6-mediated STAT3 R729me2a in breast cancer metastasis, revealing that PRMT6 positively regulates breast cancer metastasis through its effect on STAT3. Furthermore, the study identifies STAT3 R729me2a as a robust prognostic marker for predicting overall survival time in breast cancer patients. Additionally, the PRMT6 inhibitor EPZ020411 demonstrates significant potential in curbing breast cancer metastasis.
CELL DEATH & DISEASE
(2023)
Article
Oncology
Shuangjie Liu, Zhuonan Liu, Chiyuan Piao, Zhe Zhang, Chuize Kong, Lei Yin, Xi Liu
Summary: The study reveals PRMT5 as a therapeutic target for bladder cancer and identifies FKA, extracted from the kava plant, as an inhibitor of PRMT5 for the treatment of bladder cancer.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2022)
Review
Biochemistry & Molecular Biology
Ji Hye Kim, Byong Chul Yoo, Woo Seok Yang, Eunji Kim, Sungyoul Hong, Jae Youl Cho
Summary: Cells have developed a sophisticated signaling pathway in response to DNA damage, with protein arginine methylation playing critical roles in modulating DNA repair proteins and maintaining genome integrity. PRMTs can directly methylate DNA repair proteins or deposit methylation marks on histones to regulate various cellular processes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Nutrition & Dietetics
Igor Pravst, Ziva Lavrisa, Masa Hribar, Hristo Hristov, Naska Kvarantan, Barbara Korousic Seljak, Matej Gregoric, Urska Blaznik, Nadan Gregoric, Katja Zaletel, Adrijana Oblak, Josko Osredkar, Katja Zmitek, Anita Kusar
Summary: Folate deficiency is common in Slovenia, with low folate intake observed in various age groups. Public health strategies are needed to promote the consumption of folate-rich foods and supplementation with folic acid may be necessary in specific vulnerable populations.
Article
Cell Biology
Nagif Alata Jimenez, Pablo H. Strobl-Mazzulla
Summary: This study reveals the impact of folate deficiency on the specification and territorial restriction of progenitor cells during early embryonic development. The findings suggest that folate deficiency induces methylation changes in specific genomic regions, leading to a dysregulation of signaling pathways in the neural plate and NPB territories.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Clinical Neurology
Babak Hooshmand, Franziska Appold, Patrick Fissler, Robert Perneczky, Markus Otto, Hayrettin Tumani, Miia Kivipelto, Christine A. F. von Arnim
Summary: This study investigated the association between vitamin B12 status and biomarkers of Alzheimer's disease. The results suggest that vitamin B12-related markers are associated with AD biomarkers and cognitive performance. Vitamin B12 supplementation may be important in slowing down brain changes and cognitive decline.
ANNALS OF NEUROLOGY
(2023)
Article
Biochemistry & Molecular Biology
Mahmoud I. Khalil, Heba M. Ismail, Ganna Panasyuk, Anna Bdzhola, Valeriy Filonenko, Ivan Gout, Olivier E. Pardo
Summary: Ribosomal S6 kinases (S6Ks) play crucial roles in cell growth, homeostasis, and survival, and dysregulation of these kinases is implicated in various malignancies. While S6K1 has been extensively studied, the involvement of S6K2 in cancer progression has been overlooked. This study reveals that p54-S6K2 undergoes asymmetric dimethylation at Arg-475 and Arg-477, mediated by methyltransferases PRMT1, PRMT3, and PRMT6. This methylation event leads to nuclear localization of S6K2, which is crucial for its pro-survival effects during starvation-induced cell death. These findings highlight a novel post-translational modification that regulates p54-S6K2 function, and its relevance in cancer progression where general arginine methylation is often elevated.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cell Biology
Annika Schmidt, Jana Frei, Ansgar Poetsch, Alexandra Chittka, Hui Zhang, Chris Assmann, Anne Lehmkuhl, Uta-Maria Bauer, Ulrike A. Nuber, M. Cristina Cardoso
Summary: This study identified and validated novel post-translational modifications of MeCP2 in the brain, showing that these modifications can modulate its ability to bind to and reorganize heterochromatin, which may play a role in the pathology of Rett syndrome.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Biochemical Research Methods
Feng Gao, Mengyang Chang, Xiang Meng, Hang Xu, Giri Gnawali, Yue Dong, Byrdie Lopez, Wei Wang
Summary: This article reports a method for selectively modifying secondary amines in peptides, proteins, and natural products. By fine-tuning the electronic effect of ynones, the reactivity of the Michael acceptor can be controlled for selective reaction with structurally different secondary amines in complex structures and biological environments.
BIOCONJUGATE CHEMISTRY
(2023)
Article
Pharmacology & Pharmacy
Priya Singh, Soniya Charles, Thirumurthy Madhavan, Ganesh Munusamy-Ramanujam, N. T. Saraswathi, Mariadhas Valan Arasu, Naif Abdullah Al-Dhabi, Aziz Arshad, Jesu Arockiaraj, Kanchana Mala
Summary: The study investigated the impact of TAM and ADOX on PAM in ER-positive breast cancer cells, finding that the two compounds independently trigger cell cycle arrest and downregulate PAM, with a synergistic effect on anti-cancer activity. However, the reduction in ADMA was not directly proportional to the downregulation of PRMT1 mRNA, suggesting a complex interplay with other methyltransferases. Additionally, silk degrees analysis showed that ADOX had a stronger binding affinity with PEMT or BHMT compared to TAM, indicating a potential mechanism for the protective function in breast cancer cells.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Multidisciplinary Sciences
Ying Zhang, Samantha E. Iiams, Jerome S. Menet, Paul E. Hardin, Christine Merlin
Summary: Transcriptional repression is crucial for the generation of circadian rhythms. This study reveals the essential roles of histone methyltransferase TRITHORAX and heat shock protein 68 (HSP68) in PER-mediated repression in the monarch butterfly, providing insights into the connection between circadian activation and repression.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Neurosciences
Kewei Chang, Dan Gao, Jidong Yan, Liyan Lin, Tingting Cui, Shemin Lu
Summary: Arginine methylation, mediated by arginine methyltransferases and demethylases, plays crucial roles in cellular processes and has been linked to various diseases. This review provides an overview of the biochemistry and regulatory mechanism of arginine methylation, with a focus on its roles in the central nervous system and neurological diseases.
MOLECULAR NEUROBIOLOGY
(2023)
Review
Medicine, Research & Experimental
Jiaoyang Ning, Liu Chen, Gang Xiao, Yu Zeng, Wen Shi, Guilong Tanzhu, Rongrong Zhou
Summary: PRMTs are involved in the prognosis and metastasis of tumors, and their regulation of molecular mechanisms affects tumor metastasis. Inhibiting arginine methylation can reduce tumor metastasis, and this field holds promise for clinical application.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Biochemistry & Molecular Biology
Qin Wu, David Y. Nie, Wail Ba-alawi, YiShuai Ji, ZiWen Zhang, Jennifer Cruickshank, Jillian Haight, Felipe E. Ciamponi, Jocelyn Chen, Shili Duan, Yudao Shen, Jing Liu, Sajid A. Marhon, Parinaz Mehdipour, Magdalena M. Szewczyk, Nergiz Dogan-Artun, WenJun Chen, Lan Xin Zhang, Genevieve Deblois, Panagiotis Prinos, Katlin B. Massirer, Dalia Barsyte-Lovejoy, Jian Jin, Daniel D. De Carvalho, Benjamin Haibe-Kains, XiaoJia Wang, David W. Cescon, Mathieu Lupien, Cheryl H. Arrowsmith
Summary: This study identified an inhibitor called MS023 that has antitumor growth activity in triple-negative breast cancer (TNBC). Activation of interferon responses was found to be a functional biomarker and determinant of response in TNBC cell lines and human-derived organoids. Inhibition of type I PRMT triggers an interferon response through the antiviral defense pathway.
NATURE CHEMICAL BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Josien Smits, Dimitar Tasev, Stine Andersen, Robert Szulcek, Liza Botros, Steffen Ringgaard, Asger Andersen, Anton Vonk-Noordegraaf, Pieter Koolwijk, Harm Jan Bogaard
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2018)
Review
Biochemistry & Molecular Biology
Ruben Esse, Madalena Barroso, Isabel Tavares de Almeida, Rita Castro
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2019)
Article
Nutrition & Dietetics
Helena Caldeira-Araujo, Ruben Ramos, Cristina Florindo, Isabel Rivera, Rita Castro, Isabel Tavares de Almeida
Article
Biochemistry & Molecular Biology
Ekaterina S. Gushchanskaia, Ruben Esse, Qicheng Ma, Nelson C. Lau, Alla Grishok
NUCLEIC ACIDS RESEARCH
(2019)
Article
Biochemistry & Molecular Biology
Ruben Esse, Ekaterina S. Gushchanskaia, Avery Lord, Alla Grishok
Article
Nutrition & Dietetics
Courtney A. Whalen, Floyd J. Mattie, Cristina Florindo, Bertrand van Zelst, Neil K. Huang, Isabel Tavares de Almeida, Sandra G. Heil, Thomas Neuberger, A. Catharine Ross, Rita Castro
Article
Cell Biology
Ruben Esse, Alla Grishok
Article
Biochemistry & Molecular Biology
Ines V. da Silva, Courtney A. Whalen, Floyd J. Mattie, Cristina Florindo, Neil K. Huang, Sandra G. Heil, Thomas Neuberger, A. Catharine Ross, Graca Soveral, Rita Castro
Summary: The study found that a high-fat diet resulted in exacerbated systemic inflammation and atherosclerotic phenotype in mice, with an overexpression of the AQP5 isoform in the liver, WAT, and BAT of HF-fed mice. These results suggest a novel role for AQP5 in diet-induced atherosclerosis that warrants further investigation.
Article
Nutrition & Dietetics
Rita Castro, Courtney A. Whalen, Sean Gullette, Floyd J. Mattie, Cristina Florindo, Sandra G. Heil, Neil K. Huang, Thomas Neuberger, A. Catharine Ross
Summary: This pilot study investigated the effects of mild HHcy induced by nutritional manipulation of the methionine metabolism on disease progression and specific epigenetic changes in mice. Results showed the presence of nutritional ketosis in KD and LMKD mice, with mild HHcy only detected in LMKD-fed mice. Significantly different levels of some markers were observed between control mice and the other two groups, suggesting potential factors influencing the progression of HHcy. Further studies with a larger sample size are needed to confirm these preliminary observations.
Article
Biochemistry & Molecular Biology
Ines da Silva, Sean Gullette, Cristina Florindo, Neil K. Huang, Thomas Neuberger, A. Catharine Ross, Graca Soveral, Rita Castro
Summary: Ketogenic diets may impact the expression of aquaporins in atherosclerosis models and these aquaporins are related to energy metabolism and fat accumulation.
Article
Oncology
Sangshan Tian, Devendra Paudel, Fuhua Hao, Rabin Neupane, Rita Castro, Andrew D. Patterson, Amit K. Tiwari, K. Sandeep Prabhu, Vishal Singh
Summary: This study reveals that supplementation of diet with refined inulin leads to abnormal succinate accumulation in the intestinal lumen, which contributes to promoting colon inflammation and tumorigenesis.
Article
Radiology, Nuclear Medicine & Medical Imaging
Rita Castro, Sean Gullette, Courtney Whalen, Floyd J. Mattie, Ximing Ge, A. Catharine Ross, Thomas Neuberger
Summary: We described an ex-vivo, high-resolution MRI method for imaging and quantifying aortic plaque. The method provided histology-like details of the vascular lesions and offers potential for plaque characterization in clinical applications.
MAGNETIC RESONANCE MATERIALS IN PHYSICS BIOLOGY AND MEDICINE
(2023)