PRMT inhibition induces a viral mimicry response in triple-negative breast cancer

Spliceosome-targeted therapies trigger an antiviral immune response in triple-negative breast cancer

(2021) Elizabeth A. Bowling et al.   CELL

PRMT5 inhibition disrupts splicing and stemness in glioblastoma

(2021) Patty Sachamitr et al.   Nature Communications

CARM1 Inhibition Enables Immunotherapy of Resistant Tumors by Dual Action on Tumor cells and T cells

(2021) Sushil Kumar et al.   Cancer Discovery

Epigenetic silencing by SETDB1 suppresses tumour intrinsic immunogenicity

(2021) Gabriel K. Griffin et al.   NATURE

Protein arginine methylation: from enigmatic functions to therapeutic targeting

(2021) Qin Wu et al.   NATURE REVIEWS DRUG DISCOVERY

Treatment landscape of triple-negative breast cancer — expanded options, evolving needs

(2021) Giampaolo Bianchini et al.   Nature Reviews Clinical Oncology

Epigenetic switch-induced viral mimicry evasion in chemotherapy resistant breast cancer

(2020) Genevieve Deblois et al.   Cancer Discovery

Epigenetic therapy induces transcription of inverted SINEs and ADAR1 dependency

(2020) Parinaz Mehdipour et al.   NATURE

Cancer statistics, 2019

(2019) Rebecca L. Siegel et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Targeting bivalency de-represses Indian Hedgehog and inhibits self-renewal of colorectal cancer-initiating cells

(2019) Evelyne Lima-Fernandes et al.   Nature Communications

PRMT1 loss sensitizes cells to PRMT5 inhibition

(2019) Guozhen Gao et al.   NUCLEIC ACIDS RESEARCH

Prioritization of cancer therapeutic targets using CRISPR–Cas9 screens

(2019) Fiona M. Behan et al.   NATURE

Protein arginine methyltransferase 5: A novel therapeutic target for triple‐negative breast cancers

(2019) Mathilde Vinet et al.   Cancer Medicine

Anti-tumor Activity of the Type I PRMT Inhibitor, GSK3368715, Synergizes with PRMT5 Inhibition through MTAP Loss

(2019) Andrew Fedoriw et al.   CANCER CELL

The regulation, functions and clinical relevance of arginine methylation

(2019) Ernesto Guccione et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Therapeutic Targeting of RNA Splicing Catalysis through Inhibition of Protein Arginine Methylation

(2019) Jia Yi Fong et al.   CANCER CELL

A Living Biobank of Breast Cancer Organoids Captures Disease Heterogeneity

(2018) Norman Sachs et al.   CELL

Chemoresistance Evolution in Triple-Negative Breast Cancer Delineated by Single-Cell Sequencing

(2018) Charissa Kim et al.   CELL

LSD1 Ablation Stimulates Anti-tumor Immunity and Enables Checkpoint Blockade

(2018) Wanqiang Sheng et al.   CELL

A chemical biology toolbox to study protein methyltransferases and epigenetic signaling

(2018) Sebastian Scheer et al.   Nature Communications

GSKJ4, an H3K27me3 demethylase inhibitor, effectively suppresses the breast cancer stem cells

(2017) Ningning Yan et al.   EXPERIMENTAL CELL RESEARCH

Targeting triple negative breast cancer with histone deacetylase inhibitors

(2017) Palma Fedele et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

An atlas of alternative splicing profiles and functional associations reveals new regulatory programs and genes that simultaneously express multiple major isoforms

(2017) Javier Tapial et al.   GENOME RESEARCH

Multilayered Control of Alternative Splicing Regulatory Networks by Transcription Factors

(2017) Hong Han et al.   MOLECULAR CELL

Functional Genomic Landscape of Human Breast Cancer Drivers, Vulnerabilities, and Resistance

(2016) Richard Marcotte et al.   CELL

Response and resistance to BET bromodomain inhibitors in triple-negative breast cancer

(2016) Shaokun Shu et al.   NATURE

A Potent, Selective, and Cell-Active Inhibitor of Human Type I Protein Arginine Methyltransferases

(2015) Mohammad S. Eram et al.   ACS Chemical Biology

PharmacoGx: an R package for analysis of large pharmacogenomic datasets

(2015) Petr Smirnov et al.   BIOINFORMATICS

DNA-Demethylating Agents Target Colorectal Cancer Cells by Inducing Viral Mimicry by Endogenous Transcripts

(2015) David Roulois et al.   CELL

Inhibiting DNA Methylation Causes an Interferon Response in Cancer via dsRNA Including Endogenous Retroviruses

(2015) Katherine B. Chiappinelli et al.   CELL

The Molecular Signatures Database Hallmark Gene Set Collection

(2015) Arthur Liberzon et al.   Cell Systems

A Highly Conserved Program of Neuronal Microexons Is Misregulated in Autistic Brains

(2014) Manuel Irimia et al.   CELL

Target watch: Drugging the epigenome

(2013) Samia Burridge   NATURE REVIEWS DRUG DISCOVERY

Comprehensive molecular portraits of human breast tumours

(2012) Daniel C. Koboldt et al.   NATURE

The genomic and transcriptomic architecture of 2,000 breast tumours reveals novel subgroups

(2012) Christina Curtis et al.   NATURE

Epigenetic protein families: a new frontier for drug discovery

(2012) Cheryl H. Arrowsmith et al.   NATURE REVIEWS DRUG DISCOVERY

Pattern Recognition Receptors and Inflammation

(2010) Osamu Takeuchi et al.   CELL

Dysregulation of PRMT1 and PRMT6, Type I arginine methyltransferases, is involved in various types of human cancers

(2010) Masanori Yoshimatsu et al.   INTERNATIONAL JOURNAL OF CANCER