The Pharmabiotic Approach to Treat Hyperammonemia

Safety, tolerability, and pharmacokinetics of l -ornithine phenylacetate in patients with acute liver injury/failure and hyperammonemia

(2018) R. Todd Stravitz et al.   HEPATOLOGY

Targeting CPS1 in the treatment of Carbamoyl phosphate synthetase 1 (CPS1) deficiency, a urea cycle disorder

(2017) Carmen Diez-Fernandez et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Ammonia mediates cortical hemichannel dysfunction in rodent models of chronic liver disease

(2017) Anna Hadjihambi et al.   HEPATOLOGY

L-Carnitine supplementation to reverse hyperammonemia in a patient undergoing chronic valproic acid treatment: A case report

(2017) Cecilia Maldonado et al.   JOURNAL OF INTERNATIONAL MEDICAL RESEARCH

Profile of sodium phenylbutyrate granules for the treatment of urea-cycle disorders: patient perspectives

(2017) Luis Peña-Quintana et al.   Patient Preference and Adherence

Are We Really Vastly Outnumbered? Revisiting the Ratio of Bacterial to Host Cells in Humans

(2016) Ron Sender et al.   CELL

Efficient synthesis and activity of beneficial intestinal flora of two lactulose-derived oligosaccharides

(2016) Zhen-Yuan Zhu et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Evaluation and Management of Hepatic Encephalopathy: Current Status and Future Directions

(2016) Duminda Suraweera et al.   Gut and Liver

Glycine and hyperammonemia: potential target for the treatment of hepatic encephalopathy

(2016) Rune Gangsøy Kristiansen et al.   METABOLIC BRAIN DISEASE

Carglumic acid enhances rapid ammonia detoxification in classical organic acidurias with a favourable risk-benefit profile: a retrospective observational study

(2016) Vassili Valayannopoulos et al.   Orphanet Journal of Rare Diseases

Concise Review: Updated Advances and Current Challenges in Cell Therapy for Inborn Liver Metabolic Defects

(2016) Mustapha Najimi et al.   Stem Cells Translational Medicine

Recent advances in the treatment of hyperammonemia

(2015) Simon Matoori et al.   ADVANCED DRUG DELIVERY REVIEWS

Albumin Dialysis for Liver Failure: A Systematic Review

(2015) Evangelos Tsipotis et al.   ADVANCES IN CHRONIC KIDNEY DISEASE

Impacts of Gut Bacteria on Human Health and Diseases

(2015) Yu-Jie Zhang et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Engineering the gut microbiota to treat hyperammonemia

(2015) Ting-Chin David Shen et al.   JOURNAL OF CLINICAL INVESTIGATION

Characterising the bacterial microbiota across the gastrointestinal tracts of dairy cattle: membership and potential function

(2015) Shengyong Mao et al.   Scientific Reports

Gut Microbiota Alterations can predict Hospitalizations in Cirrhosis Independent of Diabetes Mellitus

(2015) Jasmohan S. Bajaj et al.   Scientific Reports

Systematic review with meta-analysis: the effects of rifaximin in hepatic encephalopathy

(2014) N. Kimer et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Randomised clinical trial: Lactobacillus GG modulates gut microbiome, metabolome and endotoxemia in patients with cirrhosis

(2014) J. S. Bajaj et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

A Case of Multiple Misdiagnoses in a Septuagenarian

(2014) Divyansh Bajaj et al.   AMERICAN JOURNAL OF MEDICINE

Identification of an atypical calcium-dependent calmodulin binding site on the C-terminal domain of GluN2A

(2014) Gaurav Bajaj et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Urea and Ammonia Metabolism and the Control of Renal Nitrogen Excretion

(2014) I. D. Weiner et al.   Clinical Journal of the American Society of Nephrology

Probiotic VSL#3 Reduces Liver Disease Severity and Hospitalization in Patients With Cirrhosis: A Randomized, Controlled Trial

(2014) Radha K. Dhiman et al.   GASTROENTEROLOGY

Minimal ureagenesis is necessary for survival in the murine model of hyperargininemia treated by AAV-based gene therapy

(2014) C Hu et al.   GENE THERAPY

Hepatic encephalopathy in chronic liver disease: 2014 Practice Guideline by the American Association for the Study Of Liver Diseases and the European Association for the Study of the Liver

(2014) Hendrik Vilstrup et al.   HEPATOLOGY

Treating inborn errors of liver metabolism with stem cells: current clinical development

(2014) Etienne Marc Sokal   JOURNAL OF INHERITED METABOLIC DISEASE

Cerebral effects of ammonia in liver disease: current hypotheses

(2014) Peter Ott et al.   METABOLIC BRAIN DISEASE

Alterations of the human gut microbiome in liver cirrhosis

(2014) Nan Qin et al.   NATURE

Short-term survival of hyperammonemic neonates treated with dialysis

(2014) Stefano Picca et al.   PEDIATRIC NEPHROLOGY

Ingestion of Lactobacillus strain reduces anxiety and improves cognitive function in the hyperammonemia rat

(2014) Jia Luo et al.   Science China-Life Sciences

Hyperammonemia Associated with Valproic Acid Concentrations

(2014) Marta Vázquez et al.   Biomed Research International

A Randomized, Double-Blind, Controlled Trial Comparing Rifaximin Plus Lactulose With Lactulose Alone in Treatment of Overt Hepatic Encephalopathy

(2013) Barjesh Chander Sharma et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Large-Scale Survey of Gut Microbiota Associated With MHE Via 16S rRNA-Based Pyrosequencing

(2013) Zhigang Zhang et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Treatment of hyperammonemia in liver failure

(2013) Maria Jover-Cobos et al.   CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE

Bacterial Urease and its Role in Long-Lasting Human Diseases

(2013) Iwona Konieczna et al.   CURRENT PROTEIN & PEPTIDE SCIENCE

Randomized, double-blind, controlled study of glycerol phenylbutyrate in hepatic encephalopathy

(2013) Don C. Rockey et al.   HEPATOLOGY

Ornithine phenylacetate targets alterations in the expression and activity of glutamine synthase and glutaminase to reduce ammonia levels in bile duct ligated rats

(2013) M. Jover-Cobos et al.   JOURNAL OF HEPATOLOGY

Ornithine phenylacetate revisited

(2013) Maria Jover-Cobos et al.   METABOLIC BRAIN DISEASE

Use of carglumic acid in the treatment of hyperammonaemia during metabolic decompensation of patients with propionic acidaemia

(2013) M. Abacan et al.   MOLECULAR GENETICS AND METABOLISM

Elevated phenylacetic acid levels do not correlate with adverse events in patients with urea cycle disorders or hepatic encephalopathy and can be predicted based on the plasma PAA to PAGN ratio

(2013) M. Mokhtarani et al.   MOLECULAR GENETICS AND METABOLISM

Can Lactobacillus acidophilus improve minimal hepatic encephalopathy? A neurometabolite study using magnetic resonance spectroscopy

(2013) Dina H. Ziada et al.   Arab Journal of Gastroenterology

Ammonia-Lowering Strategies for the Treatment of Hepatic Encephalopathy

(2012) C F Rose   CLINICAL PHARMACOLOGY & THERAPEUTICS

Probiotic/Synbiotic Therapy for Treating Critically Ill Patients from a Gut Microbiota Perspective

(2012) Kentaro Shimizu et al.   DIGESTIVE DISEASES AND SCIENCES

Effects of Fractionated Plasma Separation and Adsorption on Survival in Patients With Acute-on-Chronic Liver Failure

(2012) Andreas Kribben et al.   GASTROENTEROLOGY

Suggested guidelines for the diagnosis and management of urea cycle disorders

(2012) Johannes Häberle et al.   Orphanet Journal of Rare Diseases

Branched-chain amino acids increase arterial blood ammonia in spite of enhanced intrinsic muscle ammonia metabolism in patients with cirrhosis and healthy subjects

(2011) Gitte Dam et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Characterization of fecal microbial communities in patients with liver cirrhosis

(2011) Yanfei Chen et al.   HEPATOLOGY

Induction and Prevention of Severe Hyperammonemia in the spfash Mouse Model of Ornithine Transcarbamylase Deficiency Using shRNA and rAAV-mediated Gene Delivery

(2011) Sharon C Cunningham et al.   MOLECULAR THERAPY

Carglumic acid approved to treat genetic hyperammonemia

(2010) C. A. Thompson   AMERICAN JOURNAL OF HEALTH-SYSTEM PHARMACY

Recent advances in liver stem cell therapy

(2010) Tatiana Kisseleva et al.   CURRENT OPINION IN GASTROENTEROLOGY

Drug therapy: Rifaximin1

(2010) Jasmohan S. Bajaj et al.   HEPATOLOGY

Liver, liver cell and stem cell transplantation for the treatment of urea cycle defects

(2010) Jochen Meyburg et al.   MOLECULAR GENETICS AND METABOLISM

Rifaximin Treatment in Hepatic Encephalopathy

(2010) Nathan M. Bass et al.   NEW ENGLAND JOURNAL OF MEDICINE

Ammonia toxicity and its prevention in inherited defects of the urea cycle

(2009) V. Walker   DIABETES OBESITY & METABOLISM

Efficacy of L-Ornithine L-Aspartate in Acute Liver Failure: A Double-Blind, Randomized, Placebo-Controlled Study

(2009) Subrat Kumar Acharya et al.   GASTROENTEROLOGY

L-ornithine and phenylacetate synergistically produce sustained reduction in ammonia and brain water in cirrhotic rats

(2009) Nathan A. Davies et al.   HEPATOLOGY

Comparative genomic analysis of Lactobacillus rhamnosus GG reveals pili containing a human- mucus binding protein

(2009) M. Kankainen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Extracorporeal Liver Support Therapy With Prometheus in Patients With Liver Failure in the Intensive Care Unit

(2009) Michael Oppert et al.   THERAPEUTIC APHERESIS AND DIALYSIS

Microbes in Gastrointestinal Health and Disease

(2008) Andrew S. Neish   GASTROENTEROLOGY

Control of acute, chronic, and constitutive hyperammonemia by wild-type and genetically engineered Lactobacillus plantarum in rodents

(2008) Charles Nicaise et al.   HEPATOLOGY

Probiotics and Liver Disease

(2008) Anish A. Sheth et al.   JOURNAL OF CLINICAL GASTROENTEROLOGY

Gut ammonia production and its modulation

(2008) Manuel Romero-Gómez et al.   METABOLIC BRAIN DISEASE

Identifying the direct effects of ammonia on the brain

(2008) Cristina R. Bosoi et al.   METABOLIC BRAIN DISEASE

Carglumic acid: an additional therapy in the treatment of organic acidurias with hyperammonemia?

(2008) Virginie Levrat et al.   Orphanet Journal of Rare Diseases

Glycine cleavage system: reaction mechanism, physiological significance, and hyperglycinemia

(2008) Goro KIKUCHI et al.   PROCEEDINGS OF THE JAPAN ACADEMY SERIES B-PHYSICAL AND BIOLOGICAL SCIENCES