Brain activity patterns in high-throughput electrophysiology screen predict both drug efficacies and side effects

Serotonergic Modulation as Effective Treatment for Dravet Syndrome in a Zebrafish Mutant Model

(2016) Jo Sourbron et al.   ACS Chemical Neuroscience

Five-year extended follow-up status of 10 patients with Dravet syndrome treated with fenfluramine

(2016) Berten Ceulemans et al.   EPILEPSIA

Low-dose fenfluramine significantly reduces seizure frequency in Dravet syndrome: a prospective study of a new cohort of patients

(2016) A. Schoonjans et al.   EUROPEAN JOURNAL OF NEUROLOGY

Adaptive deep brain stimulation in Parkinson's disease

(2016) M. Beudel et al.   PARKINSONISM & RELATED DISORDERS

CHD2variants are a risk factor for photosensitivity in epilepsy

(2015) Elizabeth C. Galizia et al.   BRAIN

Cross-species pharmacological characterization of the allylglycine seizure model in mice and larval zebrafish

(2015) Karine Leclercq et al.   EPILEPSY & BEHAVIOR

TheSCN1AMutation Database: Updating Information and Analysis of the Relationships among Genotype, Functional Alteration, and Phenotype

(2015) Heng Meng et al.   HUMAN MUTATION

PoLi: A Virtual Screening Pipeline Based on Template Pocket and Ligand Similarity

(2015) Ambrish Roy et al.   Journal of Chemical Information and Modeling

Animal models in epilepsy research: legacies and new directions

(2015) Brian P Grone et al.   NATURE NEUROSCIENCE

SCN2Aencephalopathy

(2015) Katherine B. Howell et al.   NEUROLOGY

Low-dose fenfluramine in the treatment of neurologic disorders: experience in Dravet syndrome

(2015) An-Sofie Schoonjans et al.   Therapeutic Advances in Neurological Disorders

Pharmacological Characterization of an Antisense Knockdown Zebrafish Model of Dravet Syndrome: Inhibition of Epileptic Seizures by the Serotonin Agonist Fenfluramine

(2015) Yifan Zhang et al.   PLoS One

Pediatric super-refractory status epilepticus treated with allopregnanolone

(2014) Eileen Broomall et al.   ANNALS OF NEUROLOGY

Exome sequencing identifies a de novoSCN2Amutation in a patient with intractable seizures, severe intellectual disability, optic atrophy, muscular hypotonia, and brain abnormalities

(2014) Anna-Lena Baasch et al.   EPILEPSIA

Discovering novel neuroactive drugs through high-throughput behavior-based chemical screening in the zebrafish

(2014) Giancarlo Bruni et al.   Frontiers in Pharmacology

In search of biomarkers in psychiatry: EEG-based measures of brain function

(2013) Gráinne McLoughlin et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS

APoc: large-scale identification of similar protein pockets

(2013) Mu Gao et al.   BIOINFORMATICS

Generation and validation of a zebrafish model of EAST (epilepsy, ataxia, sensorineural deafness and tubulopathy) syndrome

(2013) F. Mahmood et al.   Disease Models & Mechanisms

Neuroactive steroids for the treatment of status epilepticus

(2013) Michael A. Rogawski et al.   EPILEPSIA

Migraine Genetics: Part II

(2013) Stephen D. Silberstein et al.   HEADACHE

Tracking zebrafish larvae in group – Status and perspectives

(2013) Pierre R. Martineau et al.   METHODS

A systematic genome-wide analysis of zebrafish protein-coding gene function

(2013) Ross N. W. Kettleborough et al.   NATURE

Modelling and analysis of local field potentials for studying the function of cortical circuits

(2013) Gaute T. Einevoll et al.   NATURE REVIEWS NEUROSCIENCE

Novel SCN3A variants associated with focal epilepsy in children

(2013) Carlos G. Vanoye et al.   NEUROBIOLOGY OF DISEASE

Validation of the Zebrafish Pentylenetetrazol Seizure Model: Locomotor versus Electrographic Responses to Antiepileptic Drugs

(2013) Tatiana Afrikanova et al.   PLoS One

Drug screening in Scn1a zebrafish mutant identifies clemizole as a potential Dravet syndrome treatment

(2013) Scott C. Baraban et al.   Nature Communications

High-throughput hyperdimensional vertebrate phenotyping

(2013) Carlos Pardo-Martin et al.   Nature Communications

Detection of Seizure and Epilepsy Using Higher Order Statistics in the EMD Domain

(2013) S. M. Shafiul Alam et al.   IEEE Journal of Biomedical and Health Informatics

Rediscovering Trazodone for the Treatment of Major Depressive Disorder

(2012) Andrea Fagiolini et al.   CNS DRUGS

Successful use of fenfluramine as an add-on treatment for Dravet syndrome

(2012) Berten Ceulemans et al.   EPILEPSIA

Progress report on new antiepileptic drugs: A summary of the Eleventh Eilat Conference (EILAT XI)

(2012) Meir Bialer et al.   EPILEPSY RESEARCH

The origin of extracellular fields and currents — EEG, ECoG, LFP and spikes

(2012) György Buzsáki et al.   NATURE REVIEWS NEUROSCIENCE

Benzodiazepines revisited-will we ever learn?

(2011) Malcolm Lader   ADDICTION

Expression and function of KCNQ channels in larval zebrafish

(2011) Sally W. Chege et al.   Developmental Neurobiology

Electroencephalographic characteristics of Dravet syndrome

(2011) Michelle Bureau et al.   EPILEPSIA

The effects of stiripentol on GABAA receptors

(2011) Janet L. Fisher   EPILEPSIA

The genetics of Dravet syndrome

(2011) Carla Marini et al.   EPILEPSIA

New Era for Novel CNS Drug Development

(2011) William Z Potter   NEUROPSYCHOPHARMACOLOGY

Complexity of subthalamic 13–35Hz oscillatory activity directly correlates with clinical impairment in patients with Parkinson's disease

(2010) Chiung Chu Chen et al.   EXPERIMENTAL NEUROLOGY

Knockdown of zebrafish Lgi1a results in abnormal development, brain defects and a seizure-like behavioral phenotype

(2010) Y. Teng et al.   HUMAN MOLECULAR GENETICS

Spontaneous Seizures and Altered Gene Expression in GABA Signaling Pathways in a mind bomb Mutant Zebrafish

(2010) G. A. Hortopan et al.   JOURNAL OF NEUROSCIENCE

Optogenetic Localization and Genetic Perturbation of Saccade-Generating Neurons in Zebrafish

(2010) P. J. Schoonheim et al.   JOURNAL OF NEUROSCIENCE

Differential Evolution of Voltage-Gated Sodium Channels in Tetrapods and Teleost Fishes

(2010) J. Widmark et al.   MOLECULAR BIOLOGY AND EVOLUTION

High-throughput in vivo vertebrate screening

(2010) Carlos Pardo-Martin et al.   NATURE METHODS

Estimating risk for developing epilepsy: A population-based study in Rochester, Minnesota

(2010) D. C. Hesdorffer et al.   NEUROLOGY

Clinical spectrum ofSCN1Amutations

(2009) Antonio Gambardella et al.   EPILEPSIA

Challenges in the Search for Drugs to Treat Central Nervous System Disorders

(2009) S. J. Enna et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

A Role of SCN9A in Human Epilepsies, As a Cause of Febrile Seizures and As a Potential Modifier of Dravet Syndrome

(2009) Nanda A. Singh et al.   PLoS Genetics

Mutation of sodium channel SCN3A in a patient with cryptogenic pediatric partial epilepsy

(2008) Katherine D. Holland et al.   NEUROSCIENCE LETTERS