A fluorescence anisotropy assay to discover and characterize ligands targeting the maytansine site of tubulin

Pironetin Binds Covalently to αCys316 and Perturbs a Major Loop and Helix of α-Tubulin to Inhibit Microtubule Formation

(2016) Andrea E. Prota et al.   JOURNAL OF MOLECULAR BIOLOGY

Antibody–Drug Conjugates and Small Molecule–Drug Conjugates: Opportunities and Challenges for the Development of Selective Anticancer Cytotoxic Agents

(2015) Giulio Casi et al.   JOURNAL OF MEDICINAL CHEMISTRY

Metabolites of Antibody–Maytansinoid Conjugates: Characteristics and in Vitro Potencies

(2015) Wayne Widdison et al.   MOLECULAR PHARMACEUTICS

Control of microtubule organization and dynamics: two ends in the limelight

(2015) Anna Akhmanova et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

PM060184, a new tubulin binding agent with potent antitumor activity including P-glycoprotein over-expressing tumors

(2014) Marta Martínez-Díez et al.   BIOCHEMICAL PHARMACOLOGY

Ado-trastuzumab Emtansine (T-DM1): An Antibody–Drug Conjugate (ADC) for HER2-Positive Breast Cancer

(2014) John M. Lambert et al.   JOURNAL OF MEDICINAL CHEMISTRY

Targeting Microtubules by Natural Agents for Cancer Therapy

(2014) E. Mukhtar et al.   MOLECULAR CANCER THERAPEUTICS

A previously undescribed tubulin binder

(2014) J. J. Field et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A new tubulin-binding site and pharmacophore for microtubule-destabilizing anticancer drugs

(2014) A. E. Prota et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Antibody–drug conjugates: current status and future directions

(2013) Heidi L. Perez et al.   DRUG DISCOVERY TODAY

Structural basis of tubulin tyrosination by tubulin tyrosine ligase

(2013) Andrea E. Prota et al.   JOURNAL OF CELL BIOLOGY

Isolation and First Total Synthesis of PM050489 and PM060184, Two New Marine Anticancer Compounds

(2013) María Jesús Martín et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Ansamitocin P3 Depolymerizes Microtubules and Induces Apoptosis by Binding to Tubulin at the Vinblastine Site

(2013) Jubina B. Venghateri et al.   PLoS One

Molecular Mechanism of Action of Microtubule-Stabilizing Anticancer Agents

(2013) A. E. Prota et al.   SCIENCE

Abstract C214: Disorazol Z: A highly cytotoxic natural compound with antitumor properties.

(2012) B. Aicher et al.   MOLECULAR CANCER THERAPEUTICS

Drugs that target dynamic microtubules: A new molecular perspective

(2011) Richard A. Stanton et al.   MEDICINAL RESEARCH REVIEWS

XDS

(2010) Wolfgang Kabsch   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

PHENIX: a comprehensive Python-based system for macromolecular structure solution

(2010) Paul D. Adams et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Maytansine and Cellular Metabolites of Antibody-Maytansinoid Conjugates Strongly Suppress Microtubule Dynamics by Binding to Microtubules

(2010) M. Lopus et al.   MOLECULAR CANCER THERAPEUTICS

Maytansinoid-Antibody Conjugates Induce Mitotic Arrest by Suppressing Microtubule Dynamic Instability

(2010) E. Oroudjev et al.   MOLECULAR CANCER THERAPEUTICS

Microtubule Binding and Disruption and Induction of Premature Senescence by Disorazole C1

(2008) M. B. Tierno et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS