Pironetin Binds Covalently to αCys316 and Perturbs a Major Loop and Helix of α-Tubulin to Inhibit Microtubule Formation

Published 2016 View Full Article

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Title
Pironetin Binds Covalently to αCys316 and Perturbs a Major Loop and Helix of α-Tubulin to Inhibit Microtubule Formation
Authors
Keywords
microtubule-targeting agents, molecular mechanism of action, anticancer drug, protein–ligand interactions, X-ray crystallography
Journal
JOURNAL OF MOLECULAR BIOLOGY
Volume 428, Issue 15, Pages 2981-2988
Publisher
Elsevier BV
Online
2016-07-06
DOI
10.1016/j.jmb.2016.06.023

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