Review
Immunology
Raefa Abou Khouzam, Klaudia Brodaczewska, Aleksandra Filipiak, Nagwa Ahmed Zeinelabdin, Stephanie Buart, Cezary Szczylik, Claudine Kieda, Salem Chouaib
Summary: The environmental and metabolic pressures in the tumor microenvironment have a significant impact on tumor development, especially hypoxia-triggered events that promote growth, enhance resistance to the immune response, and stimulate angiogenesis. Normalizing tumor vasculature can restore integrity, increase perfusion, alleviate hypoxia, and reshape anti-tumor immunity, offering potential in achieving stable vascular normalization for mature and functional blood vessels.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Oncology
Anastasia G. Gkegka, Michael I. Koukourakis, Maria Lambropoulou, Alexandra Giatromanolaki
Summary: Tumor-infiltrating lymphocytes (TILs) play a significant role in cancer progression and prognosis of patients. The tumor microenvironment (TME) may affect the anti-tumor immune response. We examined the TIL and tertiary lymphoid structure (TLS) density in the invading front and inner tumor stroma, and the lymphocyte subpopulation (CD8, CD4, FOXP3) density in 60 squamous cell carcinomas of the lip.
Article
Oncology
Isabel Quiros-Gonzalez, Michal R. Tomaszewski, Monika A. Golinska, Emma Brown, Laura Ansel-Bollepalli, Lina Hacker, Dominique-Laurent Couturier, Rosa M. Sainz, Sarah E. Bohndiek
Summary: The study suggests that photoacoustic tomography may provide an early indication of response or resistance to antiangiogenic therapy, clearly distinguishing between control, responding, and resistant tumors within just a few weeks of treatment.
Review
Cell Biology
Yuan Gu, Maximilian A. Becker, Luisa Mueller, Katharina Reuss, Frederik Umlauf, Tianci Tang, Michael D. Menger, Matthias W. Laschke
Summary: Tumor endothelial cells (TECs) are crucial for tumor angiogenesis, growth and metastasis, and small non-coding microRNAs (miRNAs) play a significant role in regulating TEC function and blood vessel formation. This review provides an overview of the regulatory mechanisms and effects of endothelial miRNAs, highlighting their involvement in fundamental angiogenesis-related signaling pathways. Targeting endothelial miRNAs represents a potential strategy for anti-angiogenic cancer therapy, but further research is needed to understand their networks and develop specific delivery technologies.
Review
Biochemistry & Molecular Biology
Mitrajit Ghosh, Anna M. Lenkiewicz, Bozena Kaminska
Summary: Immunotherapies have become powerful tools in treating cancer, but certain tumors, such as glioblastoma, are refractory to these treatments. The tumor microenvironment, genetic and cellular heterogeneity, and disorganized vasculature contribute to immunotherapy resistance. Understanding the role of aberrant tumor vasculature and how immune cells contribute to tumor progression and resistance is crucial in developing effective combinatorial therapies.
Review
Immunology
Areez Shafqat, Mohamed H. Omer, Eman Nayaz Ahmed, Ali Mushtaq, Eman Ijaz, Zara Ahmed, Khaled Alkattan, Ahmed Yaqinuddin
Summary: This review focuses on the immunosuppressive effects of tumor angiogenesis and coagulation on the tumor microenvironment (TME). We summarize previous research efforts leveraging these observations and targeting these processes to enhance immunotherapy outcomes. Clinical trials have documented improved outcomes when combining anti-angiogenic agents and immunotherapy, but limitations and variable treatment outcomes have been noted. Understanding the key questions and directions for further research in this field is crucial for developing effective strategies to reprogram the TME in order to advance cancer immunotherapy.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Oncology
Faheem Hyder Pottoo, Ashif Iqubal, Mohammad Kashif Iqubal, Mohammed Salahuddin, Jawad Ur Rahman, Noora AlHajri, Mustafa Shehadeh
Summary: miRNAs can modulate multiple signaling pathways of the immune system, aiding in cancer diagnosis and treatment to reduce immune escape. Although immunotherapy holds promise for cancer treatment, it faces challenges like high treatment costs, unpredictable toxicity, and uncertain clinical outcomes.
Article
Oncology
Qi Zheng, Wei Hou
Summary: MicroRNAs (miRs) are small non-coding RNA molecules that play key roles in regulating gene expression and cellular functions, particularly in angiogenesis related to tumor development and progression. Investigating the roles of miRs in angiogenesis may lead to novel strategies for treating tumors, and their potential as biomarkers for diagnosing and monitoring therapy response is also being explored.
MOLECULAR MEDICINE REPORTS
(2021)
Article
Chemistry, Multidisciplinary
Fotios Mpekris, Myrofora Panagi, Chrysovalantis Voutouri, John D. Martin, Rekha Samuel, Shinichiro Takahashi, Naoto Gotohda, Toshiyuki Suzuki, Panagiotis Papageorgis, Philippos Demetriou, Chryso Pierides, Laura Koumas, Paul Costeas, Motohiro Kojima, Genichiro Ishii, Anastasia Constantinidou, Kazunori Kataoka, Horacio Cabral, Triantafyllos Stylianopoulos
Summary: Nano-immunotherapy has shown potential in improving outcomes for triple negative breast cancer patients, but mechanisms of resistance need to be understood. By decompressing compressed blood vessels in lung metastases, perfusion can be restored and hypoxia alleviated, leading to more efficient delivery of nanomedicines and enhancement of anti-tumor immunity. Mechanotherapeutics in combination with nano-immunotherapy may offer synergistic effects on efficacy in breast cancer treatment.
Article
Chemistry, Multidisciplinary
Yuxue Xu, Feixue Ni, Daxi Sun, Yue Peng, Yaxuan Zhao, Xiaojun Wu, Shasha Li, Xiangyu Qi, Xinkang He, Min Li, Yizi Zhou, Chao Zhang, Miao Yan, Cuifang Yao, Shuaishuai Zhu, Yang Yang, Baijiao An, Chunhua Yang, Guilong Zhang, Wenguo Jiang, Jia Mi, Xinju Chen, Pengfei Wei, Geng Tian, Yin Zhang
Summary: This study reveals a novel role of glucagon in anti-cancer therapy by inhibiting angiogenesis and vascular mimicry, which enhances chemotherapy efficacy.
Article
Medicine, Research & Experimental
Yingping Zeng, Shufen Zhang, Sufen Li, Guangtao Song, Tingting Meng, Hong Yuan, Fuqiang Hu
Summary: Abnormal tumor blood vessels with high leakage can enhance tumor metastasis. Normalizing tumor blood vessels can reduce leakage and increase integrity. This study developed multifunctional nanoparticles combining chemotherapy and tumor blood vessel normalization for breast cancer treatment. The nanoparticles promoted expression of junction proteins in endothelial cells, protected endothelial cell layer integrity, and inhibited tumor cell migration and metastasis.
MOLECULAR PHARMACEUTICS
(2023)
Review
Medicine, Research & Experimental
Myrofora Panagi, Pampina Pilavaki, Anastasia Constantinidou, Triantafyllos Stylianopoulos
Summary: Sarcomas are rare malignancies that can arise throughout the human lifespan. Surgery is the best treatment option, while traditional treatments like chemotherapy and radiation have limited effectiveness. Immunotherapy has emerged as a novel approach, but its efficacy in sarcomas is limited by the tumor microenvironment. Understanding the immunological properties of the sarcoma microenvironment and their impact on immunotherapy can help overcome these barriers.
Review
Chemistry, Medicinal
Hei Jung Kim, Young Rae Ji, You Mie Lee
Summary: Understanding and overcoming the complexity and heterogeneity within the tumor microenvironment (TME) is crucial for the development of anti-cancer combination therapies. This review investigates the crosstalk between immunity and angiogenesis in the TME and explores strategies to enhance anti-cancer immunity, convert immune suppressive tumors into immune activating tumors, and improve effector immune cell infiltration.
ARCHIVES OF PHARMACAL RESEARCH
(2022)
Article
Immunology
Ken Liu, Jinbiao Chen, Yang Zhao, Jade Boland, Ka Ka Ting, Glen Lockwood, Catriona McKenzie, James Kench, Mathew A. Vadas, Jennifer R. Gamble, Geoffrey W. McCaughan
Summary: Liver cancers have abnormal vasculature, hypoxia, and immunosuppressive microenvironment. Normalization of tumor vasculature and combination of immune checkpoint inhibition have been effective in treating liver cancer. This study demonstrated that CD5-2 combined with checkpoint inhibition effectively reduced liver tumor size and improved immune infiltrate.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Oncology
Jianlin Zhu, Lu Wang, Fan Liu, Jinghua Pan, Zhimeng Yao, Yusheng Lin, Yabing Yang, Xiao Xiong, Kai Li, Yi Yang, Yiran Zhang, Xiaodong Chu, Yunlong Pan, Hao Zhang
Summary: This study found that PELP1 is abnormally upregulated in colorectal cancer (CRC) and is highly coincidental with increased microvessel density (MVD). PELP1 regulates angiogenesis through the STAT3/VEGFA pathway. Inhibition of PELP1 can suppress tumor growth and angiogenesis, and enhance the efficacy of chemotherapy.
Article
Chemistry, Multidisciplinary
Guillaume Collet, Timothee Lathion, Celine Besnard, Claude Piguet, Stephane Petoud
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2018)
Article
Physics, Applied
Giovanni Busco, Azadeh Valinataj Omran, Loick Ridou, Jean-Michel Pouvesle, Eric Robert, Catherine Grillon
JOURNAL OF PHYSICS D-APPLIED PHYSICS
(2019)
Article
Toxicology
A. Leskow, M. Nawrocka, M. Latkowska, M. Tarnowska, N. Galas, A. Matejuk, I Calkosinski
HUMAN & EXPERIMENTAL TOXICOLOGY
(2019)
Article
Immunology
Adrien A. Blisnick, Ladislav Simo, Catherine Grillon, Fabienne Fasani, Sebastien Brule, Bernard Le Bonniec, Eric Prina, Maud Marsot, Anthony Relmy, Sandra Blaise-Boisseau, Jennifer Richardson, Sarah Bonnet
Article
Chemistry, Multidisciplinary
Jacob C. Lutter, Svetlana V. Eliseeva, Guillaume Collet, Ivana Martinic, Jeff W. Kampf, Bernadette L. Schneider, Aidan Carichner, Julien Sobilo, Stephanie Lerondel, Stephane Petoud, Vincent L. Pecoraro
CHEMISTRY-A EUROPEAN JOURNAL
(2020)
Article
Biochemistry & Molecular Biology
Anne-Claire Lagree, Fabienne Fasani, Clotilde Rouxel, Marine Pivet, Marie Pourcelot, Aurore Fablet, Aurore Romey, Gregory Caignard, Damien Vitour, Sandra Blaise-Boisseau, Claudine Kieda, Henri-Jean Boulouis, Nadia Haddad, Catherine Grillon
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Review
Immunology
Agata Matejuk, Richard M. Ransohoff
FRONTIERS IN IMMUNOLOGY
(2020)
Review
Biochemistry & Molecular Biology
Giovanni Busco, Eric Robert, Nadira Chettouh-Hammas, Jean-Michel Pouvesle, Catherine Grillon
FREE RADICAL BIOLOGY AND MEDICINE
(2020)
Review
Clinical Neurology
Agata Matejuk, Arthur A. Vandenbark, Halina Offner
Summary: The immune system plays a crucial role in maintaining tissue homeostasis and integrity, beyond self-recognition, from early development to ensure proper organ function later in life. Recent research shows that immune cells in the blood can support the CNS through neuroimmune communication, challenging the traditional view of peripheral immunity being detrimental to the nervous system. Understanding the cross-talk between the CNS and the immune system is essential to uncover neurodestructive and neuroprotective immune mechanisms for more effective therapeutic strategies in health and disease.
FRONTIERS IN NEUROLOGY
(2021)
Review
Immunology
Arthur A. Vandenbark, Halina Offner, Szymon Matejuk, Agata Matejuk
Summary: The brain is the body's most unique and complex organ, and neurological disorders are the result of a failure of the nervous system multifaceted cellular networks. Microglia and astrocytes play important roles in neurological disorders, and understanding their contributions can lead to advances in related fields.
JOURNAL OF NEUROINFLAMMATION
(2021)
Article
Chemistry, Multidisciplinary
Frederic Foucher, Antonio Hrvat, Frances Westall, Celine Besnard, Guillaume Collet, Stephane Petoud
Summary: This study reports a new method of generating chiral structural hierarchy from nonchiral MOFs, and verifies the hypotheses through real-time optical microscopy observations.
CRYSTAL GROWTH & DESIGN
(2022)
Article
Chemistry, Multidisciplinary
Guillaume Collet, Antonio Hrvat, Svetlana Eliseeva, Celine Besnard, Anton Kovalenko, Stephane Petoud
Summary: This study presents a lanthanide-based metal-organic framework (MOF) that emits near-infrared (NIR) light with Yb3+ sensitized by fluorescein (FL) as a low energy absorbing chromophore (FL@CD-MOF-161). The unique design of CD-MOF-161 allows for efficient loading and spreading of chromophores within the crystal volume, achieved by trapping FL molecules in its pores during synthesis and crystal growth.
CHEMICAL COMMUNICATIONS
(2021)
Article
Physics, Fluids & Plasmas
Azadeh Valinataj Omran, Giovanni Busco, Loick Ridou, Sebastien Dozias, Catherine Grillon, Jean-Michel Pouvesle, Eric Robert
PLASMA SOURCES SCIENCE & TECHNOLOGY
(2020)
Article
Nanoscience & Nanotechnology
Ivana Martinic, Svetlana Eliseeva, Guillaume Collet, Tian-Yi Luo, Nathaniel Rosi, Stephane Petoud
ACS APPLIED BIO MATERIALS
(2019)
Review
Immunology
Agata Matejuk
ARCHIVUM IMMUNOLOGIAE ET THERAPIAE EXPERIMENTALIS
(2018)
