Depletion of ATR selectively sensitizes ATM-deficient human mammary epithelial cells to ionizing radiation and DNA-damaging agents

NCI’s provocative questions on cancer: some answers to ignite discussion

(2015) Mikhail V. Blagosklonny   Oncotarget

Development of Synthetic Lethality Anticancer Therapeutics

(2014) Bingliang Fang   JOURNAL OF MEDICINAL CHEMISTRY

ATR Inhibition Broadly Sensitizes Ovarian Cancer Cells to Chemotherapy Independent of BRCA Status

(2013) C. J. Huntoon et al.   CANCER RESEARCH

Targeting ATR in DNA damage response and cancer therapeutics

(2013) Emmanouil Fokas et al.   CANCER TREATMENT REVIEWS

Dissecting cellular responses to irradiation via targeted disruptions of the ATM-CHK1-PP2A circuit

(2013) Stela S. Palii et al.   CELL CYCLE

Ataxia Telangiectasia Mutated and Rad3 Related (ATR) Protein Kinase Inhibition Is Synthetically Lethal in XRCC1 Deficient Ovarian Cancer Cells

(2013) Rebeka Sultana et al.   PLoS One

Modulation of DNA repair by pharmacological inhibitors of the PIKK protein kinase family

(2012) M. Raymond V. Finlay et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

The novel ATR inhibitor VE-821 increases sensitivity of pancreatic cancer cells to radiation and chemotherapy

(2012) Remko Prevo et al.   CANCER BIOLOGY & THERAPY

Chk’ing p53-deficient breast cancers

(2012) David W. Schoppy et al.   JOURNAL OF CLINICAL INVESTIGATION

Targeting DNA repair mechanisms in cancer

(2012) John M. Furgason et al.   PHARMACOLOGY & THERAPEUTICS

Targeting ATR in vivo using the novel inhibitor VE-822 results in selective sensitization of pancreatic tumors to radiation

(2012) E Fokas et al.   Cell Death & Disease

ATR signalling: more than meeting at the fork

(2011) Edward A. Nam et al.   BIOCHEMICAL JOURNAL

Ataxia Telangiectasia and Rad3-Related Overexpressing Cancer Cells Induce Prolonged G2 Arrest and Develop Resistance to Ionizing Radiation

(2011) Young-Mee Kim et al.   DNA AND CELL BIOLOGY

Targeting the S and G2 checkpoint to treat cancer

(2011) Tao Chen et al.   DRUG DISCOVERY TODAY

Preclinical Development of the Novel Chk1 Inhibitor SCH900776 in Combination with DNA-Damaging Agents and Antimetabolites

(2011) R. Montano et al.   MOLECULAR CANCER THERAPEUTICS

Targeting ATR and Chk1 kinases for cancer treatment: A new model for new (and old) drugs

(2011) Luis I. Toledo et al.   Molecular Oncology

Selective killing of ATM- or p53-deficient cancer cells through inhibition of ATR

(2011) Philip M Reaper et al.   Nature Chemical Biology

Autophagy as a target for anticancer therapy

(2011) Filip Janku et al.   Nature Reviews Clinical Oncology

ATR mediates cisplatin resistance in a p53 genotype-specific manner

(2011) N Sangster-Guity et al.   ONCOGENE

Autophagy contributes to resistance of tumor cells to ionizing radiation

(2011) Hassan Chaachouay et al.   RADIOTHERAPY AND ONCOLOGY

Autophagy inhibition enhances apoptosis triggered by BO-1051, an N-mustard derivative, and involves the ATM signaling pathway

(2010) Li-Hsin Chen et al.   BIOCHEMICAL PHARMACOLOGY

Autophagy is a therapeutic target in anticancer drug resistance

(2010) Suning Chen et al.   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

Mechanism of Radiosensitization by the Chk1/2 Inhibitor AZD7762 Involves Abrogation of the G2Checkpoint and Inhibition of Homologous Recombinational DNA Repair

(2010) Meredith A. Morgan et al.   CANCER RESEARCH

AMPK-mediated autophagy inhibits apoptosis in cisplatin-treated tumour cells

(2010) L. Harhaji-Trajkovic et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Radiation-induced autophagy in normal and cancer cells: Towards novel cytoprotection and radio-sensitization policies?

(2009) Christos E. Zois et al.   Autophagy

The combined status of ATM and p53 link tumor development with therapeutic response

(2009) H. Jiang et al.   GENES & DEVELOPMENT

The induction of autophagy by γ-radiation contributes to the radioresistance of glioma stem cells

(2009) Stephanie L. Lomonaco et al.   INTERNATIONAL JOURNAL OF CANCER

Single-Stranded DNA Orchestrates an ATM-to-ATR Switch at DNA Breaks

(2009) Bunsyo Shiotani et al.   MOLECULAR CELL

DNA Protein Kinase Dependent G2 Checkpoint Revealed following Knockdown of Ataxia-Telangiectasia Mutated in Human Mammary Epithelial Cells

(2008) S. J.H. Arlander et al.   CANCER RESEARCH

Blocked Autophagy Sensitizes Resistant Carcinoma Cells to Radiation Therapy

(2008) A. Apel et al.   CANCER RESEARCH

Somatic mutations affect key pathways in lung adenocarcinoma

(2008) Li Ding et al.   NATURE