Review
Food Science & Technology
L. B. Olvera-Rosales, A. E. Cruz-Guerrero, J. M. Garcia-Garibay, L. C. Gomez-Ruiz, E. Contreras-Lopez, F. Guzman-Rodriguez, L. G. Gonzalez-Olivares
Summary: Bioactive peptides derived from whey proteins have various potential health benefits, such as immunomodulatory, antibacterial, antihypertensive, antioxidant, and opioid activities. Clinical studies are crucial to evaluate the suitability of these peptides for applications in food technology.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2022)
Article
Chemistry, Analytical
Ying Chen, Bin Liu, Zhengbo Chen, Xia Zuo
Summary: Enrichment techniques for phosphopeptides often involve interactions between phosphate groups and metal ions or metal oxides. In this study, an electrochemical sensor based on TiO2 NPs was designed to detect phosphopeptides in protein samples pretreated with AuNPs, showing high sensitivity and a wide linear concentration range. Additionally, TiO2 and GO composite materials were synthesized to enhance the detection capability, with the uniformly dispersed anatase crystal TiO2 and GO composite-modified electrode exhibiting a lower detection limit.
ANALYTICAL CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Haiyan Xue, Jingjing Han, Baoyuan He, Meixia Yi, Xiaofeng Liu, Hongxin Song, Jingying Li
Summary: In this study, casein was labeled with FITC to track its digestion and absorption in Sprague Dawley (SD) rats. The results showed that CN-FITC exhibited good labeling stability in the gastrointestinal digestive juice both in vivo and in vitro, with the maximum peptide content achieved 2 hours after administration. LC-MS-MS analysis identified potential bioactive peptides derived from beta-casein, highlighting the physiological activity of casein hydrolysate in vivo.
Article
Food Science & Technology
Qingyan Guo, Pengfei Chen, Xianggui Chen
Summary: Bioactive peptides (BAPs) derived from fermented foods have gained popularity due to their potential health benefits. Fermented foods provide a cost-effective and high-quality source of BAPs with antihypertensive, antioxidant, and antibacterial activities. However, there is a lack of research and effective exploration of BAPs resources in fermented foods. This review discusses the current research status, preparation methods, biological functions, and digestive stability of BAPs in fermented foods, as well as future directions for their application in the food and pharmaceutical fields.
JOURNAL OF FUNCTIONAL FOODS
(2023)
Article
Food Science & Technology
Waqas N. Baba, Bincy Baby, Priti Mudgil, Chee-Yuen Gan, Ranjit Vijayan, Sajid Maqsood
Summary: This study investigated the ACE inhibiting potential of peptic camel whey hydrolysates under different hydrolysis conditions. Through peptide sequencing and in silico analysis, specific peptides with potential ACE and renin inhibitory activities were identified. Enzymatic hydrolysis of camel whey proteins may release peptides with potential anti-hypertensive properties.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Liting Jia, Lin Wang, Chun Liu, Ying Liang, Qinlu Lin
Summary: Bioactive peptides are a class of peptides with special physiological functions that have gained much research attention due to their potential applications in human health and disease prevention. These peptides have diverse functions such as antioxidation, antibacterial properties, and anti-inflammation, and are mainly produced through enzymatic hydrolysis or microbial fermentation.
Review
Biochemistry & Molecular Biology
Lei Luo, Peter Muiruri Kamau, Ren Lai
Summary: The venom of wasps contains various bioactive components, including peptides and proteins, which possess antimicrobial, anti-inflammatory, antitumor, and anticoagulant activities. These bioactive peptides and proteins may be potential sources of pharmaceutically active molecules. However, the venom can also cause allergic reactions and tissue damage.
Review
Chemistry, Analytical
Ignacio Ortea
Summary: This review highlights how omics technologies are used to study the impact of diets, foods, or food components on health and disease. By analyzing genes, epigenetics, proteins, and metabolites, researchers can obtain information about functional mechanisms and cellular processes. Foodomics is a valuable approach for developing nutritional intervention strategies and identifying biomarkers linking nutrition and health.
TRAC-TRENDS IN ANALYTICAL CHEMISTRY
(2022)
Review
Food Science & Technology
Kevion K. Darmawan, Tom C. Karagiannis, Jeff G. Hughes, Darryl M. Small, Andrew Hung
Summary: This review provides comprehensive information on the structure and function of lactoferrin, as well as its binding with various molecules for food purposes, with a special emphasis on the use of molecular dynamics simulations. The results demonstrate the application of modeling and simulations in determining key residues of lactoferrin responsible for its stability and interactions with other biomolecular components.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2023)
Article
Chemistry, Applied
Barbara E. Meza, Juan Manuel Peralta, Susana E. Zorrilla
Summary: The study focused on the effect of temperature and composition on the rheological behavior and sagging capacity of glaze materials used for food coating applications. Results showed that as the content of fat and protein increased while temperature decreased, the materials exhibited viscoelastic fluid behavior. Flow curves could be described using different models and formulations with similar film thickness but higher sagging viscosity were found to have less probability for the sagging phenomenon to occur.
FOOD HYDROCOLLOIDS
(2021)
Review
Biochemistry & Molecular Biology
Veymar G. Tacias-Pascacio, Daniel Castaneda-Valbuena, Roberto Morellon-Sterling, Olga Tavano, Angel Berenguer-Murcia, Gilber Vela-Gutierrez, Irfan A. Rather, Roberto Fernandez-Lafuente
Summary: The article focuses on the application of papain in the hydrolysis of proteins from fish residues, converting the residual material into interesting products with antioxidant, nutritional, and functional activities.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Food Science & Technology
Ruichang Gao, Qingqing Yu, Yang Shen, Qian Chu, Ge Chen, Siyu Fen, Mingxuan Yang, Li Yuan, David Julian McClements, Quancai Sun
Summary: This article discusses the methods of producing bioactive protein hydrolysates and peptides from underutilized fish protein by-products, as well as the various biological activities they possess. Further research is needed to develop large-scale commercially viable extraction and purification methods, establish structure-function relationships for peptides, and conduct human studies on peptide bioactivity.
TRENDS IN FOOD SCIENCE & TECHNOLOGY
(2021)
Article
Multidisciplinary Sciences
Anita Chaudhary, Sherry Bhalla, Sumeet Patiyal, Gajendra P. S. Raghava, Girish Sahni
Summary: FermFooDb is a manually curated database containing bioactive peptides derived from a variety of fermented foods. These peptides have various therapeutic potentials, including antihypertensive, antioxidant, and antimicrobial benefits. This database serves as a valuable resource for exploring the full therapeutic potential of fermented foods from specific cultures for the food industry and researchers.
Article
Agriculture, Multidisciplinary
Yanina E. Rossi, Noelia L. Vanden Braber, Ladislao I. Diaz Vergara, Mariana A. Montenegro
Summary: The agro-industry byproducts have the potential to be an important source of bioactive ingredients for high-value functional foods. Advancements in micro- and nanoencapsulation systems help stabilize these bioactive agents in food products.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2021)
Article
Food Science & Technology
Shilpa Vij, Reenu Kashyap, Kapil Singh Narayan
Summary: In this study, bioactive peptides with immunomodulatory and antimicrobial activity were successfully isolated and identified from fermented buffalo colostrum whey. The peptide fraction of <10 kDa exhibited remarkable immunomodulatory activity, while the permeate fraction of <10 kDa showed higher antimicrobial activity against E. coli pathogens.
JOURNAL OF FUNCTIONAL FOODS
(2022)
Review
Nutrition & Dietetics
Monica Cerutti Martellet, Fernanda Majolo, Rodrigo Gay Ducati, Claucia Fernanda Volken de Souza, Marcia Ines Goettert
Summary: This article highlights the importance of using probiotics associated with fibers from Psyllium as prebiotics to maintain a healthy intestinal microbiota. The combination has the potential to remedy imbalances in gastrointestinal tract diseases by reducing the adhesion of pathogenic microorganisms. Coating technologies and encapsulating materials can increase the survival rate of these strains in the gastrointestinal tract.
Review
Pharmacology & Pharmacy
Nathalia Grave, Thamiris Becker Scheffel, Fernanda Fernandes Cruz, Liliana Rockenbach, Marcia Ines Goettert, Stefan Laufer, Fernanda Bueno Morrone
Summary: Gliomas are debilitating malignant brain tumors with limited response to therapies, driven by molecular abnormalities like mutations in regulatory networks. The MAPK pathway, particularly p38 MAPK activation, plays a crucial role in glioma cell invasion and metastasis, and is associated with tumor grade and chemotherapy resistance, underlining its potential as a therapeutic target.
FRONTIERS IN PHARMACOLOGY
(2022)
Editorial Material
Cell Biology
Lavynia Ferreira Hoffmann, Alexandre Martins, Fernanda Majolo, Veronica Contini, Stefan Laufer, Marcia Ines Goettert
NEURAL REGENERATION RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Adriano Gennari, Renate Simon, Bruna Coelho de Andrade, Daniel Kuhn, Gaby Renard, Jocelei Maria Chies, Giandra Volpato, Claucia Fernanda Volken de Souza
Summary: This study aimed to determine the effects of different feeding strategies on the production of beta-galactosidase fused to a cellulose-binding domain (CBD). The highest enzyme activity was obtained in fed-batch cultivations controlled by DO-stat and induced with lactose at 18 h of cultivation. The use of ricotta whey as an inducer significantly increased enzyme productivity.
PROCESS BIOCHEMISTRY
(2023)
Article
Food Science & Technology
Daniel Kuhn, Claudia Schlabitz, Maiara Giroldi, Daniel Neutzling Lehn, Lucelia Hoehne, Claucia Fernanda Volken de Souza
Summary: This study validated a method for quantifying free amino acids in cheese whey protein concentrate and hydrolysate using GC-MS. Trichloroacetic acid was found to enable the determination of 13 free amino acids. The method was validated in terms of recovery, limits of detection, and limits of quantification, and can be used in food laboratories for quantifying amino acids in solid dairy products.
INTERNATIONAL DAIRY JOURNAL
(2023)
Article
Food Science & Technology
Lilian de Fatima Ferreira da Silva, Ketlin Fernanda Rodrigues, Adriano Gennari, Eduardo Miranda Ethur, Lucelia Hoehne, Claucia Fernanda Volken de Souza, Elisete Maria de Freitas
Summary: The flour from the unripe fruit of Vasconcellea quercifolia showed potential as a prebiotic for Lactobacillus acidophilus and Bifidobacterium lactis, promoting the growth and viability of these probiotic bacteria. The physical and chemical parameters of the flour remained stable during storage.
JOURNAL OF FOOD SCIENCE AND TECHNOLOGY-MYSORE
(2023)
Review
Biotechnology & Applied Microbiology
Fernanda Leonhardt, Adriano Gennari, Graziela Barbosa Paludo, Caroline Schmitz, Filipe Xerxeneski da Silveira, Debora Cristina Daenecke Albuquerque Moura, Gaby Renard, Giandra Volpato, Claucia Fernanda Volken de Souza
Summary: The study analyzed various affinity tags for one-step purification and immobilization of recombinant proteins. The PRISMA methodology was used to structure the systematic review, and a total of 267 articles were selected from the Scopus and Web of Science databases. The results identified seven types of tags used in the past decade, with the CBM tag being the most effective for protein purification and immobilization.
Article
Food Science & Technology
Monica Cerutti Martellet, Fernanda Majolo, Larissa Cima, Marcia Ines Goettert, Claucia Fernanda Volken de Souza
Summary: In this study, the yeast Kluyveromyces marxianus was successfully encapsulated with the prebiotic Plantago ovata in particles coated with cheese whey, showing high cell viability and bioavailability. The encapsulated yeasts demonstrated resistance to acidic conditions and adhesion to enteral cells, indicating their potential for use in functional foods and pharmaceutical products.
Article
Environmental Sciences
Larissa Aline Carneiro Lobo, Peterson Alves Santos, Jayne Torres de Sousa, Jaqueline Nascimento Picada, Sara Elis Bianchi, Valquiria Linck Bassani, Francisco Carlos da Silva, Eduardo Miranda Ethur, Marcia Ines Goettert, Patricia Pereira
Summary: The aim of this study was to determine the toxicity profile of Hymenaea courbaril stem bark hydroalcoholic extract using various assays including cell lines and in vivo models. The extract showed potent antioxidant activity and low toxicity and mutagenicity in vitro. However, further studies are needed to investigate the biological relevance of the extract's effect on the survival of Caenorhabditis elegans.
JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A-CURRENT ISSUES
(2023)
Article
Biochemistry & Molecular Biology
Gabriela Rabaioli Rama, Luis Fernando Saraiva Macedo Timmers, Claucia Fernanda Volken de Souza
Summary: In this study, we investigated the potential of bioactive peptides from cheese whey to bind with collagenase and elastase. Through molecular docking and molecular dynamics simulations, we found that these peptides have favorable interactions with the active sites of the enzymes. Our results also revealed that collagenase has stronger binding affinity compared to elastase, and we identified several promising peptides for further study.
MOLECULAR BIOTECHNOLOGY
(2023)
Review
Immunology
Alexandre Martins, Magali Conte, Marcia Ines Goettert, Veronica Contini
Summary: This review comprehensively assesses the current evidence for plant-based treatment of ADHD, as well as their ability to modulate the inflammatory process. The findings suggest that treatment with baicalin, Sansonite, Ginkgo biloba, Korean Red ginseng, Klamath, and Crocus sativus L. can significantly improve symptoms of inattention and hyperactivity/impulsivity in both animal models and human studies. These plants also demonstrate potential in modulating the inflammatory process through various mechanisms.
INFLAMMOPHARMACOLOGY
(2023)
Review
Chemistry, Applied
Caroline Schmitz, Isabel Marie Grambusch, Daniel Neutzling Lehn, Lucelia Hoehne, Claucia Fernanda Volken de Souza
Summary: In this review, 105 articles were systematically analyzed to identify the methodologies, analytical techniques, and food matrices commonly used in the quantification of selenium (Se) in food. Inductively coupled plasma mass spectrometry (ICP-MS) was found to be the most frequently used analytical technique. The common hydrolysis methodology involved the use of nitric acid combined with ultrasound. The study highlights the importance of developing alternative, faster, and lower-cost protocols for quantifying Se in foods and beverages.
Article
Biotechnology & Applied Microbiology
Angelica Vincenzi, Marcia Ines Goettert, Claucia Fernanda Volken de Souza
Summary: This study isolated lactic acid bacteria (LAB) from raw cow milk and artisan cheese in Southern Brazil to evaluate their adhesion capacity and anti-inflammatory activity. The LAB strains, including Lentilactobacillus parabuchneri ML4, Lacticaseibacillus paracasei ML33, Lactiplantibacillus pentosus ML82, Lactiplantibacillus plantarum CH131, and L. paracasei CH135, showed high adhesion potential and anti-inflammatory activity. The strains increased TNF-α levels after a short treatment, but significantly decreased TNF-α release after a longer treatment. IL-10 levels significantly increased with LAB treatment. The inhibition of p38/MAPK phosphorylation was identified as one of the mechanisms by which L. paracasei ML33 and L. plantarum CH131 suppressed TNF-α production and release.
JOURNAL OF APPLIED MICROBIOLOGY
(2023)
Article
Chemistry, Medicinal
Karoline B. Waitman, Larissa C. de Almeida, Marina C. Primi, Jorge A. E. G. Carlos, Claudia Ruiz, Thales Kronenberger, Stefan Laufer, Marcia Ines Goettert, Antti Poso, Sandra V. Vassiliades, Vinicius A. M. de Souza, Monica F. Z. J. Toledo, Neuza M. A. Hassimotto, Michael D. Cameron, Thomas D. Bannister, Leticia Costa-Lotufo, Joa o A. Machado-Neto, Mauricio T. Tavares, Roberto Parise-Filho
Summary: A series of hybrid inhibitors combining pharmacophores of known kinase inhibitors and benzohydroxamate HDAC inhibitors were synthesized and evaluated for their anticancer activity and pharmacokinetic properties. Compounds 4d-f exhibited promising cytotoxicity against hematological cells and moderate activity against solid tumor models. Compound 4d showed potent inhibition of multiple kinase targets and had stable interactions with HDAC and members of the JAK family. These compounds showed selective cytotoxicity with minimal effects on non-tumorigenic cells and favorable pharmacokinetic profiles.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2024)
