Dipeptidyl-Peptidase 4 Inhibitor Sitagliptin Ameliorates Hepatic Insulin Resistance by Modulating Inflammation and Autophagy in ob/ob Mice

Hepatocyte-secreted DPP4 in obesity promotes adipose inflammation and insulin resistance

(2018) Devram S. Ghorpade et al.   NATURE

AMPK as a Therapeutic Target for Treating Metabolic Diseases

(2017) Emily A. Day et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

JNK at the crossroad of obesity, insulin resistance, and cell stress response

(2017) Giovanni Solinas et al.   Molecular Metabolism

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

(2016) Daniel J Klionsky et al.   Autophagy

DPP-4 Inhibition by Linagliptin Attenuates Obesity-Related Inflammation and Insulin Resistance by Regulating M1/M2 Macrophage Polarization

(2016) Fen Zhuge et al.   DIABETES

Sitagliptin vs. placebo for non-alcoholic fatty liver disease: A randomized controlled trial

(2016) Jeffrey Cui et al.   JOURNAL OF HEPATOLOGY

Impaired macrophage autophagy induces systemic insulin resistance in obesity

(2016) Young-Ho Kang et al.   Oncotarget

Blocking Nuclear Factor-Kappa B Protects against Diet-Induced Hepatic Steatosis and Insulin Resistance in Mice

(2016) Tianshu Zeng et al.   PLoS One

DPP-IV inhibitor anagliptin exerts anti-inflammatory effects on macrophages, adipocytes, and mouse livers by suppressing NF-κB activation

(2015) Takanori Shinjo et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Impaired macrophage autophagy increases the immune response in obese mice by promoting proinflammatory macrophage polarization

(2015) Kun Liu et al.   Autophagy

Inhibition of DPP-4 reduces acute mortality after myocardial infarction with restoration of autophagic response in type 2 diabetic rats

(2015) Hiromichi Murase et al.   Cardiovascular Diabetology

Depletion of Kupffer cells attenuates systemic insulin resistance, inflammation and improves liver autophagy in high-fat diet fed mice

(2015) Tian-shu Zeng et al.   ENDOCRINE JOURNAL

DPP4 in diabetes

(2015) Diana Röhrborn   Frontiers in Immunology

Effect of sitagliptin treatment on metabolism and cardiac function in genetic diabetic mice

(2014) Bianca Hemmeryckx et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Macrophages, Immunity, and Metabolic Disease

(2014) Joanne C. McNelis et al.   IMMUNITY

Effects of sitagliptin therapy on markers of low-grade inflammation and cell adhesion molecules in patients with type 2 diabetes

(2014) André J. Tremblay et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Systemic autophagy insufficiency compromises adaptation to metabolic stress and facilitates progression from obesity to diabetes

(2014) Yu-Mi Lim et al.   Nature Communications

Polysaccharide from Fuzi Likely Protects Against Starvation-Induced Cytotoxicity in H9c2 Cells by Increasing Autophagy Through Activation of the AMPK/mTOR Pathway

(2013) Li-Zhen Liao et al.   AMERICAN JOURNAL OF CHINESE MEDICINE

Autophagy regulates inflammation following oxidative injury in diabetes

(2013) Yang Wang et al.   Autophagy

Angiotensin-Converting Enzyme 2 Deficiency Aggravates Glucose Intolerance via Impairment of Islet Microvascular Density in Mice with High-Fat Diet

(2013) Li Yuan et al.   Journal of Diabetes Research

A dipeptidyl peptidase-4 inhibitor, sitagliptin, exerts anti-inflammatory effects in type 2 diabetic patients

(2012) Noriko Satoh-Asahara et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

The cellular and signaling networks linking the immune system and metabolism in disease

(2012) Olivia Osborn et al.   NATURE MEDICINE

JNK Expression by Macrophages Promotes Obesity-Induced Insulin Resistance and Inflammation

(2012) M. S. Han et al.   SCIENCE

Dipeptidyl Peptidase 4 Is a Novel Adipokine Potentially Linking Obesity to the Metabolic Syndrome

(2011) D. Lamers et al.   DIABETES

Kupffer cell depletion prevents but has no therapeutic effect on metabolic and inflammatory changes induced by a high-fat diet

(2011) Nicolas Lanthier et al.   FASEB JOURNAL

Cellular mechanism of insulin resistance in nonalcoholic fatty liver disease

(2011) N. Kumashiro et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Defective Hepatic Autophagy in Obesity Promotes ER Stress and Causes Insulin Resistance

(2010) Ling Yang et al.   Cell Metabolism

Depletion of Liver Kupffer Cells Prevents the Development of Diet-Induced Hepatic Steatosis and Insulin Resistance

(2009) W. Huang et al.   DIABETES

IL6 as a mediator of insulin resistance: fat or fiction?

(2009) T. L. Allen et al.   DIABETOLOGIA

Autophagy in the liver

(2008) Xiao-Ming Yin et al.   HEPATOLOGY

Analyzing real-time PCR data by the comparative CT method

(2008) Thomas D Schmittgen et al.   Nature Protocols