Multicomponent polysaccharide–protein bioconjugation in the development of antibacterial glycoconjugate vaccine candidates

Conjugation of PEG-hexadecane markedly increases the immunogenicity of pneumococcal polysaccharide conjugate vaccine

(2017) Xin Chang et al.   VACCINE

Towards the next generation of biomedicines by site-selective conjugation

(2016) Qi-Ying Hu et al.   CHEMICAL SOCIETY REVIEWS

The adjuvant effect of TLR7 agonist conjugated to a meningococcal serogroup C glycoconjugate vaccine

(2016) Agnese Donadei et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Solution- and Solid-Phase Macrocyclization of Peptides by the Ugi–Smiles Multicomponent Reaction: Synthesis of N-Aryl-Bridged Cyclic Lipopeptides

(2016) Micjel C. Morejón et al.   ORGANIC LETTERS

Sugar-Protein Connectivity Impacts on the Immunogenicity of Site-SelectiveSalmonellaO-Antigen Glycoconjugate Vaccines

(2015) Giuseppe Stefanetti et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Advances in Chemical Protein Modification

(2015) Omar Boutureira et al.   CHEMICAL REVIEWS

Macrocyclization of Peptide Side Chains by the Ugi Reaction: Achieving Peptide Folding and Exocyclic N-Functionalization in One Shot

(2015) Aldrin V. Vasco et al.   JOURNAL OF ORGANIC CHEMISTRY

Site-selective protein-modification chemistry for basic biology and drug development

(2015) Nikolaus Krall et al.   Nature Chemistry

Bidirectional macrocyclization of peptides by double multicomponent reactions

(2015) Manuel G. Ricardo et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Small Heterocycles in Multicomponent Reactions

(2014) Benjamin H. Rotstein et al.   CHEMICAL REVIEWS

Investigating the immunodominance of carbohydrate antigens in a bivalent unimolecular glycoconjugate vaccine against serogroup A and C meningococcal disease

(2014) Roberto Adamo et al.   GLYCOCONJUGATE JOURNAL

Selective chemical protein modification

(2014) Christopher D. Spicer et al.   Nature Communications

Vaccines against invasive Salmonella disease

(2014) Calman A MacLennan et al.   Human Vaccines & Immunotherapeutics

Burden of typhoid fever in low-income and middle-income countries: a systematic, literature-based update with risk-factor adjustment

(2014) Vittal Mogasale et al.   Lancet Global Health

Higher-order multicomponent reactions: beyond four reactants

(2013) Sebastian Brauch et al.   CHEMICAL SOCIETY REVIEWS

Exocyclic Control of Turn Induction in Macrocyclic Peptide Scaffolds

(2013) Serge Zaretsky et al.   CHEMISTRY-A EUROPEAN JOURNAL

Carbohydrate–steroid conjugation by Ugi reaction: one-pot synthesis of triple sugar/pseudo-peptide/spirostane hybrids

(2012) Daniel G. Rivera et al.   CARBOHYDRATE RESEARCH

Chemistry and Biology Of Multicomponent Reactions

(2012) Alexander Dömling et al.   CHEMICAL REVIEWS

Multicomponent Synthesis of Ugi-Type Ceramide Analogues and Neoglycolipids from Lipidic Isocyanides

(2012) Karell Pérez-Labrada et al.   JOURNAL OF ORGANIC CHEMISTRY

Recent applications of multicomponent reactions in medicinal chemistry

(2012) Paul Slobbe et al.   MedChemComm

Multicomponent Reaction Design in the Quest for Molecular Complexity and Diversity

(2011) Eelco Ruijter et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A mechanism for glycoconjugate vaccine activation of the adaptive immune system and its implications for vaccine design

(2011) Fikri Y Avci et al.   NATURE MEDICINE

The 13-valent pneumococcal conjugate vaccine (PCV13) elicits cross-functional opsonophagocytic killing responses in humans to Streptococcus pneumoniae serotypes 6C and 7A

(2011) David Cooper et al.   VACCINE

Advances in pneumococcal vaccines: the 13-valent pneumococcal conjugate vaccine received market authorization in Europe

(2010) Ralf R Reinert et al.   Expert Review of Vaccines

Macrocyclization of Linear Peptides Enabled by Amphoteric Molecules

(2010) Ryan Hili et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Bioorthogonal Chemistry: Fishing for Selectivity in a Sea of Functionality

(2009) Ellen M. Sletten et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Synthesis of Threefold Glycosylated Proteins using Click Chemistry and Genetically Encoded Unnatural Amino Acids

(2009) Emine Kaya et al.   CHEMBIOCHEM

Natural Product Synthesis Using Multicomponent Reaction Strategies

(2009) Barry B. Touré et al.   CHEMICAL REVIEWS

Applications of Multicomponent Reactions to the Synthesis of Diverse Heterocyclic Scaffolds

(2009) James D. Sunderhaus et al.   CHEMISTRY-A EUROPEAN JOURNAL

Burden of invasive pneumococcal disease and serotype distribution among Streptococcus pneumoniae isolates in young children in Europe: impact of the 7-valent pneumococcal conjugate vaccine and considerations for future conjugate vaccines

(2009) Daniel J. Isaacman et al.   INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES

Carbohydrates: A Frontier in Medicinal Chemistry

(2009) Pierre Stallforth et al.   JOURNAL OF MEDICINAL CHEMISTRY

Preparation of thermostable trypsin–polysaccharide neoglycoenzymes through Ugi multicomponent reaction

(2009) Ariel García et al.   JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC

Synthesis of Bivalent Lactosides Based on Terephthalamide,N,N′-Diglucosylterephthalamide, and Glycophane Scaffolds and Assessment of Their Inhibitory Capacity on Medically Relevant Lectins

(2009) Rosaria Leyden et al.   JOURNAL OF ORGANIC CHEMISTRY

From Disulfide- to Thioether-Linked Glycoproteins

(2008) Gonçalo J. L. Bernardes et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Heterocycles as Key Substrates in Multicomponent Reactions: The Fast Lane towards Molecular Complexity

(2008) Nicolas Isambert et al.   CHEMISTRY-A EUROPEAN JOURNAL

Facile Conversion of Cysteine and Alkyl Cysteines to Dehydroalanine on Protein Surfaces: Versatile and Switchable Access to Functionalized Proteins

(2008) Gonçalo J. L. Bernardes et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The role of Streptococcus pneumoniae virulence factors in host respiratory colonization and disease

(2008) Aras Kadioglu et al.   NATURE REVIEWS MICROBIOLOGY

Attachment of Peptide Building Blocks to Proteins Through Tyrosine Bioconjugation

(2007) Dante W. Romanini et al.   BIOCONJUGATE CHEMISTRY