Aryl transition metal chemical warheads for protein bioconjugation

Palladium Oxidative Addition Complexes for Peptide and Protein Cross-linking

(2018) Koji Kubota et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Recent developments in peptide macrocyclization

(2018) Jie Wu et al.   TETRAHEDRON LETTERS

Direct 11CN-Labeling of Unprotected Peptides via Palladium-Mediated Sequential Cross-Coupling Reactions

(2017) Wenjun Zhao et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Enzymatic conjugation using branched linkers for constructing homogeneous antibody–drug conjugates with high potency

(2017) Yasuaki Anami et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Water-Soluble Palladium Reagents for Cysteine S-Arylation under Ambient Aqueous Conditions

(2017) Anthony J. Rojas et al.   ORGANIC LETTERS

Divergent unprotected peptide macrocyclisation by palladium-mediated cysteine arylation

(2017) Anthony J. Rojas et al.   Chemical Science

Protein modification via alkyne hydrosilylation using a substoichiometric amount of ruthenium(ii) catalyst

(2017) Terence T.-L. Kwan et al.   Chemical Science

Triggered Drug Release from an Antibody–Drug Conjugate Using Fast “Click-to-Release” Chemistry in Mice

(2016) Raffaella Rossin et al.   BIOCONJUGATE CHEMISTRY

Chemical Protein Modification through Cysteine

(2016) Smita B. Gunnoo et al.   CHEMBIOCHEM

All-in-One azides: empowered click reaction for in vivo labeling and imaging of biomolecules

(2016) Yaning Su et al.   CHEMICAL COMMUNICATIONS

Palladium-Catalyzed Chemoselective and Biocompatible Functionalization of Cysteine-Containing Molecules at Room Temperature

(2016) Riyadh Ahmed Atto Al-Shuaeeb et al.   CHEMISTRY-A EUROPEAN JOURNAL

Biaryl Phosphine Based Pd(II) Amido Complexes: The Effect of Ligand Structure on Reductive Elimination

(2016) Pedro Luis Arrechea et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Selective chemical labeling of proteins

(2016) Xi Chen et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Advances in transition-metal catalyzed thioetherification reactions of aromatic compounds

(2016) Arash Ghaderi   TETRAHEDRON

Antibody-drug conjugates: recent advances in conjugation and linker chemistries

(2016) Kyoji Tsuchikama et al.   Protein & Cell

Double Strain-Promoted Macrocyclization for the Rapid Selection of Cell-Active Stapled Peptides

(2015) Yu Heng Lau et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Advances in chemical labeling of proteins in living cells

(2015) Qi Yan et al.   CELL AND TISSUE RESEARCH

Virtually Instantaneous, Room-Temperature [11C]-Cyanation Using Biaryl Phosphine Pd(0) Complexes

(2015) Hong Geun Lee et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Peptide/Protein Stapling and Unstapling: Introduction of s-Tetrazine, Photochemical Release, and Regeneration of the Peptide/Protein

(2015) Stephen P. Brown et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Antibody Conjugates with Unnatural Amino Acids

(2015) Trevor J. Hallam et al.   MOLECULAR PHARMACEUTICS

Organometallic palladium reagents for cysteine bioconjugation

(2015) Ekaterina V. Vinogradova et al.   NATURE

Imaging and manipulating proteins in live cells through covalent labeling

(2015) Lin Xue et al.   Nature Chemical Biology

Site-selective protein-modification chemistry for basic biology and drug development

(2015) Nikolaus Krall et al.   Nature Chemistry

Metabolic alkene labeling and in vitro detection of histone acylation via the aqueous oxidative Heck reaction

(2015) Maria E. Ourailidou et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Finding the Right (Bioorthogonal) Chemistry

(2014) David M. Patterson et al.   ACS Chemical Biology

Copper-Chelating Azides for Efficient Click Conjugation Reactions in Complex Media

(2014) Valentina Bevilacqua et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Progress towards Bioorthogonal Catalysis with Organometallic Compounds

(2014) Timo Völker et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Developments in the Field of Bioorthogonal Bond Forming Reactions—Past and Present Trends

(2014) Mathias King et al.   BIOCONJUGATE CHEMISTRY

Cyclometalated gold(iii) complexes for chemoselective cysteine modification via ligand controlled C–S bond-forming reductive elimination

(2014) Karen Ka-Yan Kung et al.   CHEMICAL COMMUNICATIONS

Storable N-phenylcarbamate palladacycles for rapid functionalization of an alkyne-encoded protein

(2014) Gang Cheng et al.   CHEMICAL COMMUNICATIONS

Cellular Incorporation of Unnatural Amino Acids and Bioorthogonal Labeling of Proteins

(2014) Kathrin Lang et al.   CHEMICAL REVIEWS

Transition metal-mediated bioorthogonal protein chemistry in living cells

(2014) Maiyun Yang et al.   CHEMICAL SOCIETY REVIEWS

Palladium-mediated chemistry in living cells

(2014) Sunay V Chankeshwara et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Role of the Base in Buchwald–Hartwig Amination

(2014) Ylva Sunesson et al.   JOURNAL OF ORGANIC CHEMISTRY

N-Heterocyclic Carbene-Stabilized Palladium Complexes as Organometallic Catalysts for Bioorthogonal Cross-Coupling Reactions

(2014) Xueji Ma et al.   JOURNAL OF ORGANIC CHEMISTRY

Amine-Selective Bioconjugation Using Arene Diazonium Salts

(2014) Stefan Diethelm et al.   ORGANIC LETTERS

Cyclometallated Gold(III) Complexes as Effective Catalysts for Synthesis of Propargylic Amines, Chiral Allenes and Isoxazoles

(2013) Karen Ka-Yan Kung et al.   ADVANCED SYNTHESIS & CATALYSIS

What is the total number of protein molecules per cell volume? A call to rethink some published values

(2013) Ron Milo   BIOESSAYS

Aqueous Oxidative Heck Reaction as a Protein-Labeling Strategy

(2013) Maria Eleni Ourailidou et al.   CHEMBIOCHEM

Bis-cyclometallated gold(iii) complexes as efficient catalysts for synthesis of propargylamines and alkylated indoles

(2013) Hok-Ming Ko et al.   CHEMICAL COMMUNICATIONS

Gold-mediated selective cysteine modification of peptides using allenes

(2013) Anna On-Yee Chan et al.   CHEMICAL COMMUNICATIONS

Storable palladacycles for selective functionalization of alkyne-containing proteins

(2013) Gang Cheng et al.   CHEMICAL COMMUNICATIONS

Bioorthogonal chemistry: strategies and recent developments

(2013) Carlo P. Ramil et al.   CHEMICAL COMMUNICATIONS

Ligand-Free Palladium-Mediated Site-Specific Protein Labeling Inside Gram-Negative Bacterial Pathogens

(2013) Jie Li et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Fast, Cell-Compatible Click Chemistry with Copper-Chelating Azides for Biomolecular Labeling

(2012) Chayasith Uttamapinant et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Site-Selective Lysine Modification of Native Proteins and Peptides via Kinetically Controlled Labeling

(2012) Xi Chen et al.   BIOCONJUGATE CHEMISTRY

Moving Pd-Mediated Protein Cross Coupling to Living Systems

(2012) Jie Li et al.   CHEMBIOCHEM

Iminoboronates: A New Strategy for Reversible Protein Modification

(2012) Pedro M. S. D. Cal et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Modification of N-Terminal α-Amino Groups of Peptides and Proteins Using Ketenes

(2012) Anna On-Yee Chan et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Synthesis of polystyrene microspheres and functionalization with Pd0 nanoparticles to perform bioorthogonal organometallic chemistry in living cells

(2012) Asier Unciti-Broceta et al.   Nature Protocols

Designer proteins: applications of genetic code expansion in cell biology

(2012) Lloyd Davis et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

From Mechanism to Mouse: A Tale of Two Bioorthogonal Reactions

(2011) Ellen M. Sletten et al.   ACCOUNTS OF CHEMICAL RESEARCH

Bioorthogonal Chemistry: Applications in Activity-Based Protein Profiling

(2011) Lianne I. Willems et al.   ACCOUNTS OF CHEMICAL RESEARCH

Palladium-mediated site-selective Suzuki–Miyaura protein modification at genetically encoded aryl halides

(2011) Christopher D. Spicer et al.   CHEMICAL COMMUNICATIONS

Vandetanib in Patients With Locally Advanced or Metastatic Medullary Thyroid Cancer: A Randomized, Double-Blind Phase III Trial

(2011) Samuel A. Wells et al.   JOURNAL OF CLINICAL ONCOLOGY

Copper-Free Sonogashira Cross-Coupling for Functionalization of Alkyne-Encoded Proteins in Aqueous Medium and in Bacterial Cells

(2011) Nan Li et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Cellular Consequences of Copper Complexes Used To Catalyze Bioorthogonal Click Reactions

(2011) David C. Kennedy et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Palladium-Mediated Cell-Surface Labeling

(2011) Christopher D. Spicer et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Storable Arylpalladium(II) Reagents for Alkene Labeling in Aqueous Media

(2011) Rebecca L. Simmons et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Transition Metal Catalyzed Synthesis of Aryl Sulfides

(2011) Chad C. Eichman et al.   MOLECULES

Choosing an effective protein bioconjugation strategy

(2011) Nicholas Stephanopoulos et al.   Nature Chemical Biology

Palladium-mediated intracellular chemistry

(2011) Rahimi M. Yusop et al.   Nature Chemistry

Gold-mediated bifunctional modification of oligosaccharidesvia a three-component coupling reaction

(2011) Karen Ka-Yan Kung et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Dialkylbiaryl phosphines in Pd-catalyzed amination: a user's guide

(2010) David S. Surry et al.   Chemical Science

Palladium-Catalyzed Hydroxylation of Aryl Halides under Ambient Conditions

(2009) Alexey G. Sergeev et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Bioorthogonal Chemistry: Fishing for Selectivity in a Sea of Functionality

(2009) Ellen M. Sletten et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Click Chemistry and Bioorthogonal Reactions: Unprecedented Selectivity in the Labeling of Biological Molecules

(2009) Michael D. Best   BIOCHEMISTRY

A General, Efficient, and Functional-Group-Tolerant Catalyst System for the Palladium-Catalyzed Thioetherification of Aryl Bromides and Iodides

(2009) Manuel A. Fernández-Rodríguez et al.   JOURNAL OF ORGANIC CHEMISTRY

Resting State and Elementary Steps of the Coupling of Aryl Halides with Thiols Catalyzed by Alkylbisphosphine Complexes of Palladium

(2009) Elsa Alvaro et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A Convenient Catalyst for Aqueous and Protein Suzuki−Miyaura Cross-Coupling

(2009) Justin M. Chalker et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Synthetic Applications of Pd(II)-Catalyzed C−H Carboxylation and Mechanistic Insights: Expedient Routes to Anthranilic Acids, Oxazolinones, and Quinazolinones

(2009) Ramesh Giri et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Theoretical Analysis of Factors Controlling Pd-Catalyzed Decarboxylative Coupling of Carboxylic Acids with Olefins

(2009) Song-Lin Zhang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Apparent Copper(II)-Accelerated Azide−Alkyne Cycloaddition

(2009) Wendy S. Brotherton et al.   ORGANIC LETTERS

Formation of ArF from LPdAr(F): Catalytic Conversion of Aryl Triflates to Aryl Fluorides

(2009) D. A. Watson et al.   SCIENCE

Biaryl Phosphane Ligands in Palladium-Catalyzed Amination

(2008) David S. Surry et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION