Article
Biochemistry & Molecular Biology
Naznin Shaikh, Padmaja Pamidimukkala
Summary: This study successfully prepared Pd@IO-Chitosan palladium-based catalyst and characterized it using various spectroscopic and microscopic techniques. The catalyst showed excellent catalytic activity in Suzuki coupling reactions, with a low loading of palladium and the ability to be recycled multiple times without significant decrease in performance.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Chemistry, Applied
Meliha cetin Korukcu, Samet Can
Summary: A series of air-stable NHC-Pd-PEPPSI-type complexes with unsymmetrical NHC ligand and a phenyl group in its backbone were successfully synthesized with high yields (82%-94%). The complexes were characterized by various spectroscopic techniques, including H-1 NMR, C-13 NMR, FT-IR spectroscopy, and HRMS. The crystal structure of the complexes was determined using single-crystal X-ray diffraction, showing a slightly distorted square planar geometry around the metal centre. The complexes exhibited excellent catalytic activities in Heck-Mizoroki and Suzuki-Miyaura cross-coupling reactions under low catalyst loadings.
APPLIED ORGANOMETALLIC CHEMISTRY
(2023)
Article
Chemistry, Physical
Zahid Nawaz, Nevin Gurbuz, Muhammad Naveed Zafar, Namik Ozdemir, Uzma Habib, Kalsoom Jan, Ismail Ozdemir
Summary: The research aims to synthesize homogeneous catalysts by starting from novel precursors to form N-heterocyclic carbene (NHC) ligands, and subsequently synthesizing Pd(NHC)-PEPPSI type complexes. The structure of all synthesized ligands and complexes was confirmed using various spectroscopic techniques, with some compounds confirmed by X-ray. These complexes were found to be significantly active as catalysts in the C-C cross-coupling reaction.
JOURNAL OF MOLECULAR STRUCTURE
(2021)
Review
Chemistry, Multidisciplinary
Ana Sousa-Castillo, Andrea Marino-Lopez, Begona Puertolas, Miguel A. Correa-Duarte
Summary: Bioorthogonal chemistry has provided a powerful tool for performing biocompatible chemospecific reactions in living systems, particularly in the areas of genetic encoding systems, bioimaging, and cancer therapy. This Minireview focuses on recent advances in the use of heterogeneous catalysts for bioorthogonal reactions, discussing the synthetic strategies of Pd-, Au-, and Cu-based materials, their applications in activating caged fluorophores and prodrugs, and the potential of using external stimuli for targeted drug release in diseased tissues. The review also highlights future directions and challenges in this emerging field.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Chemistry, Inorganic & Nuclear
Reike Clauss, Saral Baweja, Dmitri Gelman, Evamarie Hey-Hawkins
Summary: A series of novel heterobimetallic Pd-II/M-II complexes were synthesized and exhibited a cooperative effect in catalyzing coupling reactions, leading to improved catalytic activity and selectivity for the formation of various Z-alkenes. The homogeneous nature of the catalytically active species was also demonstrated in the study.
DALTON TRANSACTIONS
(2022)
Article
Chemistry, Multidisciplinary
Qingqing Liu, Jing Zhong, Funing Tian, Qiwei Wang, Yuanhua Wang, Liu Zhong, Qingfei Huang
Summary: In order to conduct green chemistry, hydrophilic catalysts with high activity and stability are necessary. A catalyst [Pd(IPr*(TEG))(cin)Cl)] was designed and synthesized for Suzuki coupling reactions in aqueous solvents, showing good to excellent yield with low catalyst loading. The catalyst can be recycled and performs well in cyclical reactions.
Article
Chemistry, Inorganic & Nuclear
Yaxu Liu, Vladislav A. Voloshkin, Thomas Scattolin, Luigi Cavallo, Busra Dereli, Catherine S. J. Cazin, Steven P. Nolan
Summary: This study demonstrates an easy conversion of [Pd-2(mu-Cl)(mu-eta(3)-R-allyl)(NHC)(2)] complexes into active [PdCl(mu-Cl)(NHC)](2) pre-catalysts using inexpensive HCl as both an oxidant and chloride source under mild conditions. DFT calculations reveal a mechanism involving a combination of two different pathways, providing insights into factors favoring and hindering Pd(I) dimer formation in catalysis.
DALTON TRANSACTIONS
(2021)
Article
Chemistry, Inorganic & Nuclear
Yaxu Liu, Thomas Scattolin, Alberto Gobbo, Marek Belis, Kristof Van Hecke, Steven P. Nolan, Catherine S. J. Cazin
Summary: The synthesis of a series of stable Pd(II)-NHC pre-catalysts with excellent catalytic activity in Suzuki-Miyaura and Buchwald-Hartwig reactions has been successfully achieved in this study, especially when IPrCl is employed as an ancillary ligand. The [Pd(IPr*)Cl(1-Bu-t-indenyl)] complex also exhibited optimal catalytic activity in the challenging Suzuki-Miyaura reaction between esters and arylboronic acids under very mild reaction conditions.
EUROPEAN JOURNAL OF INORGANIC CHEMISTRY
(2022)
Review
Chemistry, Multidisciplinary
Zikun Wang, Nikolaos V. Tzouras, Steven P. Nolan, Xihe Bi
Summary: Silver N-heterocyclic carbenes (Ag-NHCs) have good biocompatibility and are widely used in medicine and coordination chemistry, but their coordination with silver can weaken the Lewis acidity of Ag(I), resulting in slow development as catalysts. Future opportunities lie in further research on the catalytic mechanisms of Ag-NHCs to enhance their catalytic activity.
TRENDS IN CHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Tanmoy Mandal, Tapas Kumar Dutta, Sunit Mohanty, Joyanta Choudhury
Summary: The study successfully developed a highly efficient, heterogeneous, and recyclable Pd-NHC catalyst, which shows promise in the field of heterogeneous C-H functionalization where efficient catalysts are still rare.
CHEMICAL COMMUNICATIONS
(2021)
Article
Chemistry, Multidisciplinary
Adhir Majumder, Rajat Naskar, Shankab J. Phukan, Ramananda Maity
Summary: Bimetallic Pd-II complexes with mixed NHC/Py/PCy3 donor set ligands have been synthesized and evaluated as catalysts in various reactions. The complexes showed superior activity in the alpha-arylation of amide and Sonogashira coupling reactions compared to PEPPSI-type complexes.
NEW JOURNAL OF CHEMISTRY
(2022)
Article
Chemistry, Organic
Yinpeng Wang, Mingming Zhao, Jingke Peng, Hongxia Zheng, Heng-Ying Xiong, Guangwu Zhang
Summary: The first Pd(0)-catalyzed synthesis of aryl-methylene ethers from hydrobenzoxazoles (hydrothiazoles) using dichloromethane (DCM) as the C1 feedstock is reported. This protocol demonstrates a broad substrate scope (38 examples) and wide tolerance to functional groups. The aryl-methylene ether adducts have been successfully coupled with isocyanate to provide bis-iminoisoindolinones. In this reaction, DCM serves as a twofold electrophile, undergoing double C-Cl bond cleavage to react with hydrobenzoxazoles.
Review
Chemistry, Medicinal
Feiyan Zhan, Jingjie Zhu, Shaowen Xie, Jinyi Xu, Shengtao Xu
Summary: Bioorthogonal coupling reactions have gained significant interest for their substrate selectivity and less restrictive reaction conditions, making them powerful tools in drug development. This review discusses the current applications of bioorthogonal coupling reactions in compound library building, druggability optimization, and intracellular self-assembly platforms, presenting a new trend in drug development for accelerating lead compound screening and expanding the variety of designed compounds.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Chemistry, Inorganic & Nuclear
Bianca K. Munoz, Monica Viciano, Cyril Godard, Sergio Castillon, Monica Garcia-Ruiz, Ma Dolores Blanco Gonzalez, Carmen Claver
Summary: The paper discusses the use of metal complexes as catalysts in the synthesis of propylene carbonate from carbon dioxide and propylene oxide. Iron and manganese complexes showed significantly higher activities compared to new cobalt complexes. By optimizing the conditions, a TOF of 1600 h-1 was achieved with the manganese (II) complex 2.
INORGANICA CHIMICA ACTA
(2021)
Article
Chemistry, Physical
Denise Lovison, Tobias Berghausen, Sophie R. Thomas, Jonathan Robson, Markus Drees, Christian Jandl, Alexander Poethig, Patrick Mollik, Dominik P. Halter, Walter Baratta, Angela Casini
Summary: In this study, water-soluble organometallic Ru(II) complexes were synthesized and found to act as anticancer agents by catalyzing transfer hydrogenation reactions with biomolecules. The structure-activity relationship and reaction mechanism were investigated, and the compounds were also tested for their anticancer activity in vitro.
Article
Chemistry, Multidisciplinary
Jiaguo Huang, Shiyun Xian, Yi Liu, Xiaona Chen, Kanyi Pu, Hangxiang Wang
Summary: A new activatable polymeric nanoprobe (APN(SO)) for real-time in vivo near-infrared fluorescence imaging and urinalysis of hepatic ischemia-reperfusion injury (IRI) is reported, which can detect IRI at least 7 hours earlier than typical clinical assays in a mouse model.
ADVANCED MATERIALS
(2022)
Article
Chemistry, Physical
Xinting Han, Lulu Ren, Yan Ma, Xiao Gong, Hangxiang Wang
Summary: In this study, a self-repairing superhydrophobic coating with good anti-corrosion and photothermal properties was fabricated by the spaying method. The coating exhibited excellent corrosion resistance and was capable of self-repairing under sunlight. This research provides a new idea for the application of superhydrophobic coatings.
Article
Chemistry, Physical
Jiaguo Huang, Xiaona Chen, Yuyan Jiang, Chi Zhang, Shasha He, Hangxiang Wang, Kanyi Pu
Summary: This study develops activatable polyfluorophore nanosensors that can react with disease-associated proteases to produce fluorescent signals for non-invasive disease diagnosis. These nanosensors show promising results in detecting tumors and diagnosing acute liver allograft rejection in rodent models.
Article
Nanoscience & Nanotechnology
X. Shi, L. Shu, Y. Qiao, J. Yao, H. Xie, L. Zhou, H. Wang, S. Zheng
Summary: STAT3 is a key converging point of multiple oncogenic pathways and is constitutively activated in various cancer cells. Stattic, a selective inhibitor of STAT3, has shown promising potential for targeted cancer therapy and has been formulated in nanoparticles to enhance its therapeutic effects against tumor growth and metastasis.
MATERIALS TODAY NANO
(2022)
Article
Chemistry, Multidisciplinary
Suchen Bian, Haijiang Dong, Long Zhao, Zequn Li, Jian Chen, Xingxin Zhu, Nasha Qiu, Xing Jia, Wenfeng Song, Zekuan Li, Shusen Zheng, Hangxiang Wang, Penghong Song
Summary: Losartan nanoblocker (Los NB) remodels the tumor microenvironment, enhances the accumulation and penetration of drugs in tumor tissues, and improves the therapeutic efficacy. This study provides a potential clinical transformation for stroma-rich PDAC treatment.
Article
Nanoscience & Nanotechnology
Xiao Gong, Zheng Xiong, Xiaona Chen, Fanchao Meng, Hangxiang Wang
Summary: A facile method is reported to prepare multifunctional cotton fabrics with high flame retardancy, high electrical conductivity, superamphiphobicity, and high electromagnetic shielding. This was achieved by modifying the cotton fabric surface with phytic acid, coating with tannic acid and 3-aminopropyltriethoxysilane, and reducing the surface energy with fluorine-containing molecules. The resulting composite cotton fabric exhibited excellent properties in all these aspects.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Engineering, Biomedical
Kangkang Ying, Yifeng Zhu, Jianqin Wan, Chenyue Zhan, Yuchen Wang, Binbin Xie, Peirong Xu, Hongming Pan, Hangxiang Wang
Summary: This study describes a novel therapeutic strategy that utilizes polymeric prodrug design and cell membrane cloaking to create a highly effective and low-toxicity treatment. In animal model experiments, this biomimetic therapy exhibited a higher level of tumor accumulation and effectively suppressed tumor growth and metastasis.
BIOACTIVE MATERIALS
(2023)
Article
Chemistry, Physical
Xiao Gong, Qingqing Xu, Xiaona Chen, Fanchao Meng, Hangxiang Wang
Summary: This paper reports the synthesis of carbon nanodots that can efficiently absorb UV and high-energy blue light. These carbon nanodots can be easily synthesized in large scale and embedded in cellulose films, resulting in ultrahigh efficient UV and blue light shielding with guaranteed visible light transmission rate.
Article
Pharmacology & Pharmacy
Shiyun Xian, Jiabin Zhu, Yuchen Wang, Haihan Song, Hangxiang Wang
Summary: This study developed an oral liposome called budsomes to deliver the anti-inflammatory drug budesonide for the treatment of inflammatory bowel disease (IBD). The budsomes showed high stability in the stomach and released active budesonide after accumulation in inflamed intestinal tissues. Compared to free budesonide treatment, budsomes exhibited higher therapeutic efficiency and induced remission of acute colitis without adverse side effects.
Article
Multidisciplinary Sciences
Jianqin Wan, Lulu Ren, Xiaoyan Li, Shasha He, Yang Fu, Peirong Xu, Fanchao Meng, Shiyun Xian, Kanyi Pu, Hangxiang Wang
Summary: A photoactivatable toll-like receptor 7/8 (TLR7/8) nanoagonist system is developed to induce near-infrared light-induced immunogenic cell death (ICD) in dying tumor cells and release a potent immunoadjuvant. In mouse models, this system effectively eliminates tumors, suppresses tumor recurrence and metastasis, and activates tumor-specific T cells. This study provides a simple and cost-effective approach to generate in situ cancer vaccines for the photodynamic immunotherapy of metastatic cancers.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Chemistry, Multidisciplinary
Xiaowei Shi, Liwei Shu, Minwen Wang, Jie Yao, Qigu Yao, Suchen Bian, Xiaona Chen, Jianqin Wan, Fu Zhang, Shusen Zheng, Hangxiang Wang
Summary: Immune checkpoint blockade therapies have made a significant impact on cancer treatment, but many patients do not respond to these therapies. Researchers have developed a combination chemoimmunotherapy nanosystem that includes a gemcitabine prodrug nanoparticle decorated with an anti-PD-L1 antibody and a STING agonist. This nanosystem enhances drug delivery to ICB-refractory tumors, activates CD8+ T cell responses, and transforms low-immunogenic tumors into inflamed tumors. In multiple mouse tumor models, the triple-combination nanovesicles induce a strong antitumor immune response and result in regression of large tumors and reduction in metastatic burden. These findings provide a basis for developing chemoimmunotherapeutic strategies for treating ICB-nonresponsive tumors.
Article
Multidisciplinary Sciences
Xiaona Chen, Fanchao Meng, Yiting Xu, Tongyu Li, Xiaolong Chen, Hangxiang Wang
Summary: The authors developed esterase-activatable pro-drugs based on STING agonist MSA-2 that are incorporated into liposomal vesicles for targeted intravenous administration. These pro-drugs, delivered via liposomes (SAProsomes), show enhanced pharmacokinetic properties and immune stimulatory capacity. The best candidate, SAProsome-3, effectively stimulates secretion of inflammatory cytokines and creates a tumoricidal immune landscape, leading to durable remission and decreased metastatic burden in breast cancer and melanoma mouse models.
NATURE COMMUNICATIONS
(2023)
Article
Multidisciplinary Sciences
Jian Wang, Peirong Xu, Yeyong Zhang, Shuai Han, Gongteng Wang, Hangxiang Wang, Haihan Song, Shufeng Li
Summary: The study develops injectable anticancer nanoassemblies through self-assembly technique, which exhibit tumor-restricted pharmacology and can be self-activated without exogenous stimuli. The anticancer agent cabazitaxel is covalently dimerized to form the prodrug diCTX, which is further coassembled with an ROS generator diDHA. The refined nanoparticles show durable antitumor efficacy in a preclinical model and lower toxicity compared to free drug combinations, suggesting great potential for clinical translation.
Article
Medicine, General & Internal
Zhentao Yang, Haiyang Xie, Jianqin Wan, Yuchen Wang, Liang Zhang, Ke Zhou, Hong Tang, Wentao Zhao, Hangxiang Wang, Penghong Song, Shusen Zheng
Summary: A nanotherapeutic strategy was developed to deliver rapamycin and 7-ethyl-10-hydroxycamptothecin in a nanoparticle, which exhibited synergistic effects against hepatocellular carcinoma and alleviated drug resistance.
Article
Engineering, Biomedical
Tongyu Li, Weiwei Shi, Jie Yao, Jingyun Hu, Qiong Sun, Jing Meng, Jian Wan, Haihan Song, Hangxiang Wang
Summary: This study presents a strategy to integrate multiple structurally disparate drugs into a self-assembling nanococktail platform. In vitro and in vivo assays demonstrate that this nanococktail therapy can effectively mitigate chemoresistance and improve the therapeutic efficacy in lung cancer. The findings suggest the potential of this approach in synergistically treating chemoresistant cancers.
BIOMATERIALS RESEARCH
(2022)
