Phage Therapy Faces Evolutionary Challenges

Personalized medicine and proper dosage

(2018) Anthi Trasta   EMBO REPORTS

Microbial warfare against viruses

(2018) Jin-Soo Kim   SCIENCE

The Magistral Phage

(2018) Jean-Paul Pirnay et al.   Viruses-Basel

Expert Opinion on Three Phage Therapy Related Topics: Bacterial Phage Resistance, Phage Training and Prophages in Bacterial Production Strains

(2018) Christine Rohde et al.   Viruses-Basel

Bacteriophage Applications for Food Production and Processing

(2018) Zachary Moye et al.   Viruses-Basel

In Vitro Characteristics of Phages to Guide ‘Real Life’ Phage Therapy Suitability

(2018) Eoghan Casey et al.   Viruses-Basel

Network structure and local adaptation in co-evolving bacteria-phage interactions

(2017) James Gurney et al.   MOLECULAR ECOLOGY

Collective Infectious Units in Viruses

(2017) Rafael Sanjuán   TRENDS IN MICROBIOLOGY

Long-term genomic coevolution of host-parasite interaction in the natural environment

(2017) Elina Laanto et al.   Nature Communications

Bacteriophages and Bacterial Plant Diseases

(2017) Colin Buttimer et al.   Frontiers in Microbiology

Long-term effects of single and combined introductions of antibiotics and bacteriophages on populations of Pseudomonas aeruginosa

(2016) Clara Torres-Barceló et al.   Evolutionary Applications

Genetically Engineered Phages: a Review of Advances over the Last Decade

(2016) Diana P. Pires et al.   MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS

Immigration of susceptible hosts triggers the evolution of alternative parasite defence strategies

(2016) Hélène Chabas et al.   PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Does High-Dose Antimicrobial Chemotherapy Prevent the Evolution of Resistance?

(2016) Troy Day et al.   PLoS Computational Biology

More Is Better: Selecting for Broad Host Range Bacteriophages

(2016) Alexa Ross et al.   Frontiers in Microbiology

Phage selection restores antibiotic sensitivity in MDR Pseudomonas aeruginosa

(2016) Benjamin K. Chan et al.   Scientific Reports

The cost of phage resistance in a plant pathogenic bacterium is context-dependent

(2015) Sean Meaden et al.   EVOLUTION

Bacteriophage therapies re-enter clinical trials

(2015) Katie Kingwell   NATURE REVIEWS DRUG DISCOVERY

The Impact of Resource Availability on Bacterial Resistance to Phages in Soil

(2015) Pedro Gómez et al.   PLoS One

Targeting virulence: can we make evolution-proof drugs?

(2014) Richard C. Allen et al.   NATURE REVIEWS MICROBIOLOGY

Contrasted coevolutionary dynamics between a bacterial pathogen and its bacteriophages

(2014) A. Betts et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Temperate Phages Acquire DNA from Defective Prophages by Relaxed Homologous Recombination: The Role of Rad52-Like Recombinases

(2014) Marianne De Paepe et al.   PLoS Genetics

Evolutionary consequences of intra-patient phage predation on microbial populations

(2014) Kimberley D Seed et al.   eLife

PredictingIn VivoEfficacy of Therapeutic Bacteriophages Used To Treat Pulmonary Infections

(2013) Marine Henry et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Fight evolution with evolution: plasmid-dependent phages with a wide host range prevent the spread of antibiotic resistance

(2013) Ville Ojala et al.   Evolutionary Applications

Efficacy of bacteriophage LISTEX™P100 combined with chemical antimicrobials in reducing Listeria monocytogenes in cooked turkey and roast beef

(2013) Andrew Chibeu et al.   INTERNATIONAL JOURNAL OF FOOD MICROBIOLOGY

Phage-Driven Loss of Virulence in a Fish Pathogenic Bacterium

(2013) Elina Laanto et al.   PLoS One

Bacteriophage adhering to mucus provide a non-host-derived immunity

(2013) J. J. Barr et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Fitness benefits of low infectivity in a spatially structured population of bacteriophages

(2013) P. Roychoudhury et al.   PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Phage–bacteria infection networks

(2012) Joshua S. Weitz et al.   TRENDS IN MICROBIOLOGY

Local Biotic Environment Shapes the Spatial Scale of Bacteriophage Adaptation to Bacteria

(2011) Britt Koskella et al.   AMERICAN NATURALIST

Host-parasite coevolutionary arms races give way to fluctuating selection

(2011) Alex R. Hall et al.   ECOLOGY LETTERS

Co-evolution with lytic phage selects for the mucoid phenotype of Pseudomonas fluorescens SBW25

(2011) Pauline Deirdre Scanlan et al.   ISME Journal

Genetic basis of infectivity evolution in a bacteriophage

(2010) PAULINE D. SCANLAN et al.   MOLECULAR ECOLOGY

Exploitation of a new flagellatropic phage ofErwiniafor positive selection of bacterial mutants attenuated in plant virulence: towards phage therapy

(2009) T.J. Evans et al.   JOURNAL OF APPLIED MICROBIOLOGY

Bacterial Community Variation in Human Body Habitats Across Space and Time

(2009) E. K. Costello et al.   SCIENCE