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Adaptation in CRISPR-Cas Systems

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The diversity-generating benefits of a prokaryotic adaptive immune system

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CRISPR–Cas adaptation: insights into the mechanism of action

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Parasite Exposure Drives Selective Evolution of Constitutive versus Inducible Defense

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Cas9 function and host genome sampling in Type II-A CRISPR–Cas adaptation

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(2015) Luciano A. Marraffini   NATURE

Costs of CRISPR-Cas-mediated resistance inStreptococcus thermophilus

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Unravelling the structural and mechanistic basis of CRISPR–Cas systems

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Evolution of suicide as a defence strategy against pathogens in a spatially structured environment

(2013) Thomas W. Berngruber et al.   ECOLOGY LETTERS

Massive Activation of Archaeal Defense Genes during Viral Infection

(2013) T. E. F. Quax et al.   JOURNAL OF VIROLOGY

Altruism can evolve when relatedness is low: evidence from bacteria committing suicide upon phage infection

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Cytotoxic Chromosomal Targeting by CRISPR/Cas Systems Can Reshape Bacterial Genomes and Expel or Remodel Pathogenicity Islands

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The Population and Evolutionary Dynamics of Phage and Bacteria with CRISPR–Mediated Immunity

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The CRISPRs, They Are A-Changin': How Prokaryotes Generate Adaptive Immunity

(2012) Edze R. Westra et al.   Annual Review of Genetics

The CRISPR/Cas Adaptive Immune System of Pseudomonas aeruginosa Mediates Resistance to Naturally Occurring and Engineered Phages

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Bacteriophage genes that inactivate the CRISPR/Cas bacterial immune system

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Phage-Induced Expression of CRISPR-Associated Proteins Is Revealed by Shotgun Proteomics in Streptococcus thermophilus

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Success of a suicidal defense strategy against infection in a structured habitat

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Evolution of Host Life-History Traits in a Spatially Structured Host-Parasite System

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Genomic island variability facilitates Prochlorococcus–virus coexistence

(2011) Sarit Avrani et al.   NATURE

Comparison of the herbivore defense and competitive ability of ancestral and modern genotypes of an invasive plant, Lespedeza cuneata

(2011) Laura L. Beaton et al.   OIKOS

The CRISPR/Cas bacterial immune system cleaves bacteriophage and plasmid DNA

(2010) Josiane E. Garneau et al.   NATURE

Bacteriophage resistance mechanisms

(2010) Simon J. Labrie et al.   NATURE REVIEWS MICROBIOLOGY

Self-targeting by CRISPR: gene regulation or autoimmunity?

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Viral biogeography revealed by signatures inSulfolobus islandicusgenomes

(2009) Nicole L. Held et al.   ENVIRONMENTAL MICROBIOLOGY

Transcription Profile of Thermus thermophilus CRISPR Systems after Phage Infection

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Host-parasite coevolution and patterns of adaptation across time and space

(2008) S. GANDON et al.   JOURNAL OF EVOLUTIONARY BIOLOGY

Two arms are better than one: parasite variation leads to combined inducible and constitutive innate immune responses

(2008) R. Hamilton et al.   PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Small CRISPR RNAs Guide Antiviral Defense in Prokaryotes

(2008) S. J. J. Brouns et al.   SCIENCE