Article
Multidisciplinary Sciences
Shanliang Zheng, Dong Zhao, Guixue Hou, Song Zhao, Wenxin Zhang, Xingwen Wang, Li Li, Liang Lin, Tie-Shan Tang, Ying Hu
Summary: The study demonstrates the interaction between TMCO1 and iASPP in colon cancer, affecting tumor growth and cell apoptosis by modulating Ca2+ homeostasis. Intervention in the iASPP-TMCO1 axis can effectively inhibit tumor progression.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Immunology
Heena Khan, Annu Bangar, Amarjot Kaur Grewal, Puneet Bansal, Thakur Gurjeet Singh
Summary: Caspases play a crucial role in neuronal disorders and neurodegenerative diseases, and the development of caspase inhibitors as therapeutic agents is being actively studied. However, no drug targeting caspase inhibition is currently available in the market.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Julie Bas, Trang Nguyen, Germain Gillet
Summary: Bcl-2 family proteins, known for their role in regulating apoptosis, also have non-canonical functions in the CNS. Bcl-xL, a close homolog of Bcl-2, plays a crucial role in neuronal development, promoting ATP generation in mitochondria and contributing to synaptic transmission without causing cell death. Understanding the roles of cell death machinery in neurons may have important clinical implications for degenerative diseases and aging.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Nutrition & Dietetics
Sotiris Kyriakou, Louiza Potamiti, Nikoletta Demosthenous, Tom Amery, Kyle Stewart, Paul G. Winyard, Rodrigo Franco, Aglaia Pappa, Mihalis I. Panayiotidis
Summary: The aim of this study was to extract isolated fractions of watercress flowers enriched in polyphenols, phenethyl isothiocyanate and glucosinolates, and characterize their anti-cancer effects on melanoma cells and non-tumorigenic cells. The study found that the fraction enriched in phenethyl isothiocyanate had significant cytotoxicity against melanoma cells while remaining relatively non-toxic to non-tumorigenic cells. Additionally, early ultrastructural alterations in mitochondria and the endoplasmic reticulum were observed after exposure to the extract, leading to late induction of intrinsic apoptosis.
Article
Engineering, Environmental
Xudan Liu, Yao Chen, Huanhuan Wang, Yuting Wei, Ye Yuan, Qianqian Zhou, Fang Fang, Sainan Shi, Xiaojing Jiang, Yinqiao Dong, Xin Li
Summary: Arsenic is the primary toxicant among hazardous environmental chemicals, implicated in neurotoxicity such as cognitive dysfunction, neurodevelopmental changes, and neurodegenerative diseases. It is believed that sustained pro-inflammatory response may trigger arsenic-induced neurotoxicity, potentially involving microglia activation and release of pro-inflammatory cytokines. Further research is needed to clarify the role of these cytokines in arsenic-induced neurotoxicity.
JOURNAL OF HAZARDOUS MATERIALS
(2021)
Article
Neurosciences
Mohammad A. Ghane, Wei Wei, Dina W. Yakout, Zachary D. Allen, Cassandra L. Miller, Bin Dong, Jenny J. Yang, Ning Fang, Angela M. Mabb
Summary: The study found that disrupting Arc protein ubiquitination enhances DHPG-induced ER-mediated Ca2+ release. This alteration is observed in all neuronal subregions except secondary branchpoints. Disruptions in Arc ubiquitination increase Arc interaction with the integral ER protein Calnexin.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2023)
Article
Pharmacology & Pharmacy
Yazhou Guo, Chen Yang, Rong Guo, Ruijie Huang, Yongxia Su, Shuai Wang, Yezi Kong, Jianguo Wang, Chengjian Tan, Chonghui Mo, Chenchen Wu, Baoyu Zhao
Summary: The study revealed that MCT exhibits significant cytotoxicity on primary rat hepatocytes and induces ER stress, leading to apoptosis. Inhibiting ER stress or knocking down CHOP can partially alleviate cell apoptosis.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Multidisciplinary Sciences
Lauren C. Panzera, Ben Johnson, Josiah A. Quinn, In Ha Cho, Michael M. Tamkun, Michael B. Hoppa
Summary: Research indicates that Kv2.1 channels play a crucial role in facilitating ER calcium uptake during electrical activity in neurons, which is related to synaptic transmission. Loss of the Kv2.1 channel can disrupt synaptic vesicle fusion during stimulation, while its non-conducting role can link ER calcium uptake with electrical activity.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Environmental Sciences
Yosra Ben Othmene, Kevin Monceaux, Anissa Belhadef, Ahmed Karoui, Intidhar Ben Salem, Manel Boussabbeh, Salwa Abid-Essefi, Christophe Lemaire
Summary: Tebuconazole (TEB), a common triazole fungicide, has been widely used in the treatment of fungal diseases. Our study found that TEB induces apoptosis in intestinal cells through the mitochondrial pathway. It also triggers endoplasmic reticulum (ER) stress, which plays a crucial role in mediating TEB-induced toxicity. Inhibition of ROS and alleviation of ER stress can reduce TEB-induced apoptosis.
ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
(2022)
Article
Cell Biology
Zhen Tang, Xinghui Wei, Tian Li, Wei Wang, Hao Wu, Hui Dong, Yichao Liu, Feilong Wei, Lei Shi, Xiaokang Li, Zheng Guo, Xin Xiao
Summary: The study elucidates the potential role of Sestrin2 in regulating the sensitivity of osteosarcoma to chemotherapy, demonstrating that Sestrin2 activates autophagy by inhibiting the mTOR pathway and decreases apoptosis via Bcl-2, ultimately slowing down tumor progression.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Environmental Sciences
Yihui Huo, Feiyang Ma, Tingyu Li, Chaiqin Lei, Jianzhao Liao, Qingyue Han, Ying Li, Jiaqiang Pan, Lianmei Hu, Jianying Guo, Zhaoxin Tang
Summary: This study demonstrated that an overdose of copper can induce mitophagy and ER stress-mediated apoptosis in the chicken cerebrum. These findings revealed an important potential connection between copper toxicity and cerebrum damage, which provided a new insight into copper neurotoxicity.
ENVIRONMENTAL TOXICOLOGY
(2023)
Article
Pharmacology & Pharmacy
Xiaojing Fu, Wenwen Zhao, Kangkang Li, Jingyi Zhou, Xuehong Chen
Summary: The study reveals the anticancer effects of cryptotanshinone (CPT) in colorectal cancer (CRC) by activating autophagy signaling mediated by ER stress. CPT selectively inhibits the growth and proliferation of HCT116 and SW620 cells while having little effect on SW480 cells.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Chemistry, Applied
Zhi-Feng Tan, Yue Ding, Jing-Yu Tian, Zi-Qiang Liu, Jing-Ran Bi, Da-Yong Zhou, Liang Song, Gui-Bing Chen
Summary: UV irradiation caused various changes in sea cucumber coelomocytes, including calcium imbalance and abnormal morphology of the endoplasmic reticulum. Injection of the calcium chelator helped maintain intracellular calcium homeostasis in sea cucumbers and suppressed other abnormal changes. Apoptosis in sea cucumbers is mediated by calcium imbalance and follows the activation of the ER stress pathway.
Article
Environmental Sciences
Xuanxuan Jiang, Wenlan Yu, Shaofeng Wu, Lixuan Tang, Gaolong Zhong, Fang Wan, Juan Lan, Hui Zhang, Jiaqiang Pan, Zhaoxin Tang, Xiaoyong Zhang, Lianmei Hu, Riming Huang
Summary: Arsenic and antimony are environmental contaminants known for their cardiotoxicity properties. This study found that arsenic and/or antimony can cause pathological lesions and endoplasmic reticulum expansion in the heart, disrupting calcium homeostasis and inducing apoptosis through the endoplasmic reticulum stress pathway.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Article
Nutrition & Dietetics
Bo Zhang, Jun-Ting Cao, Yong-Bao Wu, Ke-Xin Gao, Ming Xie, Zheng-Kui Zhou, Jing Tang, Shui-Sheng Hou
Summary: Riboflavin deficiency induces cell apoptosis by triggering endoplasmic reticulum stress and the CHOP pathway.