Microglia-derived IL-1β promoted neuronal apoptosis through ER stress-mediated signaling pathway PERK/eIF2α/ATF4/CHOP upon arsenic exposure

Neurotoxic Mechanism of Arsenic: Synergistic Effect of Mitochondrial Instability, Oxidative Stress, and Hormonal-Neurotransmitter Impairment

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Ablation of PKM2 ameliorated ER stress‐induced apoptosis and associated inflammation response in IL‐1β‐treated chondrocytes via blocking Rspo2‐mediated Wnt/β‐catenin signaling

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Calreticulin regulated intrinsic apoptosis through mitochondria-dependent and independent pathways mediated by ER stress in arsenite exposed HT-22 cells

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Microglia-mediated neuroinflammation in neurodegenerative diseases

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Arsenic Neurotoxicity in Humans

(2019) Hitoshi Mochizuki   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Endoplasmic Reticulum Stress Induced by Toxic Elements—a Review of Recent Developments

(2019) S. V. S. Rana   BIOLOGICAL TRACE ELEMENT RESEARCH

Dose-dependent relationships between chronic arsenic exposure and cognitive impairment and serum brain-derived neurotrophic factor

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Arsenic-induced neurotoxicity: a mechanistic appraisal

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Arsenic reduction to

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Neuroprotective mechanisms of selenium against arsenic-induced behavioral impairments in rats

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Environmental arsenic exposure: From genetic susceptibility to pathogenesis

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The possible neuroprotective effect of ellagic acid on sodium arsenate-induced neurotoxicity in rats

(2018) Mehdi Goudarzi et al.   LIFE SCIENCES

Sneaky Entry of IFNγ Through Arsenic-Induced Leaky Blood–Brain Barrier Reduces CD200 Expression by Microglial pro-Inflammatory Cytokine

(2018) Vikas Singh et al.   MOLECULAR NEUROBIOLOGY

Neuronal Cell Death

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Arsenic Exposure Contributes to the Bioenergetic Damage in an Alzheimer’s Disease Model

(2018) Sandra Aurora Niño et al.   ACS Chemical Neuroscience

Microglia in neurodegeneration

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Arsenic Exposure, Assessment, Toxicity, Diagnosis, and Management

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Low-level inorganic arsenic exposure and neuropsychological functioning in American Indian elders

(2017) Clint R. Carroll et al.   ENVIRONMENTAL RESEARCH

Arsenic removal methods for drinking water in the developing countries: technological developments and research needs

(2017) Fayzul Kabir et al.   ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH

Assessment of relationship on excess arsenic intake from drinking water and cognitive impairment in adults and elders in arsenicosis areas

(2017) Jiayong Liu et al.   INTERNATIONAL JOURNAL OF HYGIENE AND ENVIRONMENTAL HEALTH

Retinoic acid and arsenic trioxide sensitize acute promyelocytic leukemia cells to ER stress

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Human health implications, risk assessment and remediation of As-contaminated water: A critical review

(2017) Muhammad Bilal Shakoor et al.   SCIENCE OF THE TOTAL ENVIRONMENT

Microglial Activation in the Pathogenesis of Huntington’s Disease

(2017) Hui-Ming Yang et al.   Frontiers in Aging Neuroscience

Sodium Arsenite-Induced Learning and Memory Impairment Is Associated with Endoplasmic Reticulum Stress-Mediated Apoptosis in Rat Hippocampus

(2017) Hongna Sun et al.   Frontiers in Molecular Neuroscience

ATF4 regulates arsenic trioxide-mediated NADPH oxidase, ER-mitochondrial crosstalk and apoptosis

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Role of Microglia in Neurological Disorders and Their Potentials as a Therapeutic Target

(2016) Li Du et al.   MOLECULAR NEUROBIOLOGY

Toxicity mechanisms of arsenic that are shared with neurodegenerative diseases and cognitive impairment: Role of oxidative stress and inflammatory responses

(2016) Claudia Escudero-Lourdes   NEUROTOXICOLOGY

Arsenic trioxide mediates HAPI microglia inflammatory response and the secretion of inflammatory cytokine IL-6 via Akt/NF-κB signaling pathway

(2016) Gang Chen et al.   REGULATORY TOXICOLOGY AND PHARMACOLOGY

Hijacking microglial glutathione by inorganic arsenic impels bystander death of immature neurons through extracellular cystine/glutamate imbalance

(2016) Vikas Singh et al.   Scientific Reports

Endoplasmic Reticulum Stress in Immunity

(2015) Sarah E. Bettigole et al.   Annual Review of Immunology

The Role of Endoplasmic Reticulum Stress in Human Pathology

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Arsenic trioxide induces programmed cell death through stimulation of ER stress and inhibition of the ubiquitin–proteasome system in human sarcoma cells

(2015) Hui-Wen Chiu et al.   CANCER LETTERS

Arsenic and human health effects: A review

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Low-level arsenic exposure and developmental neurotoxicity in children: A systematic review and risk assessment

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Environmental pollutants as risk factors for neurodegenerative disorders: Alzheimer and Parkinson diseases

(2015) Miguel Chin-Chan et al.   Frontiers in Cellular Neuroscience

Arsenic Exposure in Drinking Water Alters the Dopamine System in the Brains of C57BL/6 Mice

(2014) Minjeong Kim et al.   BIOLOGICAL TRACE ELEMENT RESEARCH

The Developmental Neurotoxicity of Arsenic: Cognitive and Behavioral Consequences of Early Life Exposure

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Association of arsenic, cadmium and manganese exposure with neurodevelopment and behavioural disorders in children: A systematic review and meta-analysis

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Arsenic induces reactive oxygen species-caused neuronal cell apoptosis through JNK/ERK-mediated mitochondria-dependent and GRP 78/CHOP-regulated pathways

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Arsenic induces apoptosis in myoblasts through a reactive oxygen species-induced endoplasmic reticulum stress and mitochondrial dysfunction pathway

(2012) Yuan-Peng Yen et al.   ARCHIVES OF TOXICOLOGY

Four types of inorganic nanoparticles stimulate the inflammatory reaction in brain microglia and damage neurons in vitro

(2012) Yang Xue et al.   TOXICOLOGY LETTERS

Inorganic arsenic causes cell apoptosis in mouse cerebrum through an oxidative stress-regulated signaling pathway

(2011) Cheng Chien Yen et al.   ARCHIVES OF TOXICOLOGY

Role of pro-inflammatory cytokines released from microglia in neurodegenerative diseases

(2011) Joshua A. Smith et al.   BRAIN RESEARCH BULLETIN

Integrating the mechanisms of apoptosis induced by endoplasmic reticulum stress

(2011) Ira Tabas et al.   NATURE CELL BIOLOGY

Neuroprotective efficacy of curcumin in arsenic induced cholinergic dysfunctions in rats

(2011) Rajesh S. Yadav et al.   NEUROTOXICOLOGY

IL-1β induces ER stress in a JNK dependent manner that determines cell death in human pancreatic epithelial MIA PaCa-2 cells

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