iASPP suppresses Gp78-mediated TMCO1 degradation to maintain Ca2+ homeostasis and control tumor growth and drug resistance

Targeting oncogenic Notch signaling with SERCA inhibitors

(2021) Luca Pagliaro et al.   Journal of Hematology & Oncology

Exercise triggers CAPN1-mediated AIF truncation, inducing myocyte cell death in arrhythmogenic cardiomyopathy

(2021) Stephen P. Chelko et al.   Science Translational Medicine

iASPP-Mediated ROS Inhibition Drives 5-Fu Resistance Dependent on Nrf2 Antioxidative Signaling Pathway in Gastric Adenocarcinoma

(2020) Lu Wen et al.   DIGESTIVE DISEASES AND SCIENCES

A previously identified apoptosis inhibitor iASPP confers resistance to chemotherapeutic drugs by suppressing senescence in cancer cells

(2020) Huayi Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ca2+ Fluxes and Cancer

(2020) Saverio Marchi et al.   MOLECULAR CELL

Type 3 inositol 1,4,5‐trisphosphate receptor is increased and enhances malignant properties in cholangiocarcinoma

(2019) Pimwipa Ueasilamongkol et al.   HEPATOLOGY

TMCO1-mediated Ca2+ leak underlies osteoblast functions via CaMKII signaling

(2019) Jianwei Li et al.   Nature Communications

Inflammation-induced Occludin Downregulation Limits Epithelial Apoptosis by Suppressing Caspase 3 Expression

(2019) Wei-Ting Kuo et al.   GASTROENTEROLOGY

Primary Active Ca2+ Transport Systems in Health and Disease

(2019) Jialin Chen et al.   Cold Spring Harbor Perspectives in Biology

IP3 Receptor Plasticity Underlying Diverse Functions

(2019) Kozo Hamada et al.   Annual Review of Physiology

Overexpression of iASPP is required for autophagy in response to oxidative stress in choriocarcinoma

(2019) Ka-Kui Chan et al.   BMC CANCER

Breast Cancer Targeting through Inhibition of the Endoplasmic Reticulum-Based Apoptosis Regulator Nrh/BCL2L10

(2018) Adrien Nougarede et al.   CANCER RESEARCH

SERCA control of cell death and survival

(2018) Elie R. Chemaly et al.   CELL CALCIUM

TMCO1 is essential for ovarian follicle development by regulating ER Ca2+ store of granulosa cells

(2018) Zhongshuai Sun et al.   CELL DEATH AND DIFFERENTIATION

Endoplasmic Reticulum–Mitochondrial Contactology: Structure and Signaling Functions

(2018) György Csordás et al.   TRENDS IN CELL BIOLOGY

Calcium Dynamics as a Machine for Decoding Signals

(2018) Carlotta Giorgi et al.   TRENDS IN CELL BIOLOGY

BAP1 regulates IP3R3-mediated Ca2+ flux to mitochondria suppressing cell transformation

(2017) Angela Bononi et al.   NATURE

PTEN counteracts FBXL2 to promote IP3R3- and Ca2+-mediated apoptosis limiting tumour growth

(2017) Shafi Kuchay et al.   NATURE

Ca 2+ Release Channels Join the ‘Resolution Revolution’

(2017) Ran Zalk et al.   TRENDS IN BIOCHEMICAL SCIENCES

Wild-type and mutant p53 differentially modulate miR-124/iASPP feedback following pohotodynamic therapy in human colon cancer cell line

(2017) Kuijie Liu et al.   Cell Death & Disease

Comparison of Concurrent Use of Thoracic Radiation With Either Carboplatin-Paclitaxel or Cisplatin-Etoposide for Patients With Stage III Non–Small-Cell Lung Cancer

(2017) Conor E. Steuer et al.   JAMA Oncology

Targeting calcium signaling in cancer therapy

(2017) Chaochu Cui et al.   Acta Pharmaceutica Sinica B

Elevated Orai1 and STIM1 expressions upregulate MACC1 expression to promote tumor cell proliferation, metabolism, migration, and invasion in human gastric cancer

(2016) Jianling Xia et al.   CANCER LETTERS

TMCO1 Is an ER Ca 2+ Load-Activated Ca 2+ Channel

(2016) Qiao-Chu Wang et al.   CELL

Ubiquitin modifications

(2016) Kirby N Swatek et al.   CELL RESEARCH

A calcium- and calpain-dependent pathway determines the response to lenalidomide in myelodysplastic syndromes

(2016) Jing Fang et al.   NATURE MEDICINE

Calcium at the Center of Cell Signaling: Interplay between Endoplasmic Reticulum, Mitochondria, and Lysosomes

(2016) Anna Raffaello et al.   TRENDS IN BIOCHEMICAL SCIENCES

Nuclear Factor, Erythroid 2-Like 2 Regulates Expression of Type 3 Inositol 1,4,5-Trisphosphate Receptor and Calcium Signaling in Cholangiocytes

(2015) Jittima Weerachayaphorn et al.   GASTROENTEROLOGY

p53 at the endoplasmic reticulum regulates apoptosis in a Ca2+-dependent manner

(2015) Carlotta Giorgi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Code for RanGDP Binding in Ankyrin Repeats Defines a Nuclear Import Pathway

(2014) Min Lu et al.   CELL

Whole-exome sequencing links TMCO1 defect syndrome with cerebro-facio-thoracic dysplasia

(2014) Davut Pehlivan et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Architecture and conformational switch mechanism of the ryanodine receptor

(2014) Rouslan G. Efremov et al.   NATURE

Cleaning up in the endoplasmic reticulum: ubiquitin in charge

(2014) John C Christianson et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

USP13 antagonizes gp78 to maintain functionality of a chaperone in ER-associated degradation

(2014) Yanfen Liu et al.   eLife

TMCO1 deficiency causes autosomal recessive cerebrofaciothoracic dysplasia

(2013) Yasemin Alanay et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

Restoring p53 Function in Human Melanoma Cells by Inhibiting MDM2 and Cyclin B1/CDK1-Phosphorylated Nuclear iASPP

(2013) Min Lu et al.   CANCER CELL

1B50-1, a mAb Raised against Recurrent Tumor Cells, Targets Liver Tumor-Initiating Cells by Binding to the Calcium Channel α2δ1 Subunit

(2013) Wei Zhao et al.   CANCER CELL

Complementary Genomic Screens Identify SERCA as a Therapeutic Target in NOTCH1 Mutated Cancer

(2013) Giovanni Roti et al.   CANCER CELL

STIM1/Orai1 coiled-coil interplay in the regulation of store-operated calcium entry

(2013) Peter B. Stathopulos et al.   Nature Communications

Blockade of store-operated Ca2+ entry inhibits hepatocarcinoma cell migration and invasion by regulating focal adhesion turnover

(2012) Ning Yang et al.   CANCER LETTERS

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

iASPP and Chemoresistance in Ovarian Cancers: Effects on Paclitaxel-Mediated Mitotic Catastrophe

(2011) L. Jiang et al.   CLINICAL CANCER RESEARCH

Genome-wide association study identifies susceptibility loci for open angle glaucoma at TMCO1 and CDKN2B-AS1

(2011) Kathryn P Burdon et al.   NATURE GENETICS

Induction of Ca2+-driven apoptosis in chronic lymphocytic leukemia cells by peptide-mediated disruption of Bcl-2-IP3 receptor interaction

(2010) F. Zhong et al.   BLOOD

Store-Independent Activation of Orai1 by SPCA2 in Mammary Tumors

(2010) Mingye Feng et al.   CELL

Increased Expression of iASPP, Regulated by Hepatitis B Virus X Protein-Mediated NF-κB Activation, in Hepatocellular Carcinoma

(2010) Bin Lu et al.   GASTROENTEROLOGY

Orai1 and STIM1 Are Critical for Breast Tumor Cell Migration and Metastasis

(2009) Shengyu Yang et al.   CANCER CELL

STIM1 Clusters and Activates CRAC Channels via Direct Binding of a Cytosolic Domain to Orai1

(2009) Chan Young Park et al.   CELL

Homozygous frameshift mutation in TMCO1 causes a syndrome with craniofacial dysmorphism, skeletal anomalies, and mental retardation

(2009) B. Xin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA